論文

査読有り 国際誌
2021年10月

Chronic liver disease enables gut Enterococcus faecalis colonization to promote liver carcinogenesis.

Nature cancer
  • Noriho Iida
  • ,
  • Eishiro Mizukoshi
  • ,
  • Tatsuya Yamashita
  • ,
  • Masahiro Yutani
  • ,
  • Jun Seishima
  • ,
  • Ziyu Wang
  • ,
  • Kuniaki Arai
  • ,
  • Hikari Okada
  • ,
  • Taro Yamashita
  • ,
  • Yoshio Sakai
  • ,
  • Yusuke Masuo
  • ,
  • Rina Agustina
  • ,
  • Yukio Kato
  • ,
  • Yukako Fujinaga
  • ,
  • Masanobu Oshima
  • ,
  • Masao Honda
  • ,
  • François Lebreton
  • ,
  • Michael S Gilmore
  • ,
  • Shuichi Kaneko

2
10
開始ページ
1039
終了ページ
1054
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/s43018-021-00251-3

Gut dysbiosis is observed in chronic hepatobiliary diseases and is frequently associated with liver carcinogenesis; however, the extent and specific mechanisms triggered by alterations in the microbiota mediating tumorigenesis in these patients remain unclear. Here we show that Enterococcus faecalis is abundant in the microbiota of patients with hepatitis C virus-related chronic liver disease. Xenotransplantation of gut microbiota from these patients increased the number of spontaneous liver tumors in mice and enhanced susceptibility to liver carcinogens. Hepatic colonization by gelE-positive E. faecalis increased liver expression of proliferative genes in a TLR4-Myd88-dependent manner, leading to liver tumorigenesis. Moreover, decreased fecal deoxycholic acid levels were associated with colonization by E. faecalis. Overall, these data identify E. faecalis as a key promoter of liver carcinogenesis.

リンク情報
DOI
https://doi.org/10.1038/s43018-021-00251-3
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/35121877
ID情報
  • DOI : 10.1038/s43018-021-00251-3
  • PubMed ID : 35121877

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