論文

査読有り 国際誌
2018年6月1日

Translocation and dissemination of botulinum neurotoxin from the intestinal tract

Toxicon
  • Yukako Fujinaga
  • ,
  • Michel R. Popoff

147
開始ページ
13
終了ページ
18
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.toxicon.2017.10.020
出版者・発行元
Elsevier Ltd

Botulinum neurotoxins (BoNTs) are potent toxins which induce flaccid paralysis by inhibiting the release of acetylcholine at the neuromuscular junctions. They associate with non-toxic proteins (ANTPs or NAPs) to form complexes of various sizes which are resistant to acidic pH and protease degradation. BoNT trafficking from the digestive tract to the target neurons is still a matter of debate. BoNTs use different strategies to pass through the intestinal barrier including passage of BoNT complexes containing hemagglutinins (HAs) via M cells, HA-dependent perturbation of E-cadherin intercellular junctions between enterocytes and paracellular passage of BoNT complexes, and transcytosis of BoNT free of NAPs through certain intestinal epithelial cells. Then, BoNTs target neuronal cells, preferentially cholinergic neurons, in the intestinal mucosa and submucosa. The precise mode of BoNT dissemination until the final target neuro-muscular junctions is still elusive.


リンク情報
DOI
https://doi.org/10.1016/j.toxicon.2017.10.020
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29074396
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000433015100003&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.toxicon.2017.10.020
  • ISSN : 1879-3150
  • ISSN : 0041-0101
  • PubMed ID : 29074396
  • SCOPUS ID : 85032982370
  • Web of Science ID : WOS:000433015100003

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