J-GLOBAL         Last updated: Oct 8, 2019 at 09:06
Health Sciences University of Hokkaido
School of Dentistry, Department of Dentistry, 2nd Department of Oral and Maxillofacial Surgery
Job title
Associate Professor
(BLANK)(Hokkaido University)

Research Areas


Academic & Professional Experience

Hokkaido University, Research Fellow
Okayama University, Research Assistant
Health Sciences University of Hokkaido, Research Assistant


Graduate School, Division of Dental Research, Hokkaido University
Faculty of Dentistry, Hokkaido University


Autogenous demineralized dentin graft for third molar socket regeneration -A case report
Md.A.Kabir, M. Murata, K. Kusano, T. Akazawa, T. Shibata
Dentistry 5   343    2015
A preclinical large animal study on a novel intervertebral fusion cage covered with high porosity titanium sheets with a triple pore structure used for spinal fusion
Katsuhisa Yamada, Manabu Ito, Toshiyuki Akazawa, Masaru Murata, Toru Yamamoto, Norimasa Iwasaki
European Spine Journal   24:2530-2537    2015
Autogenous tooth bone graft block for sinus augmentation with simulutanous implant installation: a technical note
Kwang-Ho Lee, Young-Kyun Kim, Woo-Jin Cho, In-Woong Um, Masaru Murata, Masaharu Mitsugi
J Korean Assoc Oral Maxillofac Surg   41(5): 284-289    2015
Radiological Evaluation of Human Dentin Autografts in Bangladesh.
M. A. Kabir, M. Murata, K. Kusano, S. M. Zakaria, A.H. M. Noor, F. Khuda, I. Hossain, S. Sultana and T. Saito.
Journal of Hard Tissue Biology   23:363-370    2014
Effects of demineralized dentin matrix used as an rhBMP-2 carrier for bone regeneration
Young-Kyun Kim, In-Woong Um, Hyo-Jun An, Kyung-Wook Kim, Ki-Seok Hong, Masaru Murata
Journal of Hard Tissue Biology   23:415-422    2014
南田康人, 村田 勝,草野 薫,赤澤敏之,永易裕樹
日口腔インプラント誌   27:513-520    2014
Particulate characterization of bovine bone granules pulverized with a high-speed blade mill
Tingting Wei, Akira Hishikawa, Yusuke Shimizu, Toshiyuki Akazawa, Masaru Murata, Isao Kimura
Powder Technology   261:147-153    2014
Tooth bank system for bone regeneration -Safety report-
Young-Kyun Kim, In-Woong Um, Masaru Murata
Journal of Hard Tissue Biology   23:371-376    2014
Analysis of organic components and osteoinductivity in autogenous tooth bone graft material
Young-Kyun Kim, Junho Lee, Kyung-Wook Kim, In-Woong Um, Masaru Murata, Katsutoshi Ito
J Korean Assoc Maxillofac Plast Reconstr Surg   35(6): 353-359    2013
北所弘行, 舞田健夫,村田 勝,赤澤敏之,田崎純一
日口腔インプラント誌   26(2),242-249    2013
Bone augmentation using novel unidirectional porous hydroxyapatite with BMP-2 on rat skull
H.Kashiwazaki, N.Harada, T.Akazawa, A.Kabir, Y.Minamida, M.Murata
Journal of Hard Tissue Biology   22.337-341    2013
Tooth-derived bone graft material
Young-Kyun Kim, Junho Lee, In-Woong Um, Kyung-Wook Kim, Masaru Murata, Toshiyuki Akazawa, Masaharu Mitsugi
J Korean Assoc Oral Maxillofac Surg   39(3): 103-111    2013
The effect of partial dissolution-precipitation treatment on calcium phosphate ceramics in the release of BMP-2 and osteoinduction
J. Tazaki, M. Murata, T. Akazawa, M. Yamamoto, M. Arisue, T. Shibata. H. Nagayasu, Y. Tabata.
Journal of Hard Tissue Biology   21:459-468    2012
T. AkazawaBioactive Surface Structure and Bio-absorption of Human Dentin Granules Designed by the Supersonic Demineralization and Biomimetic Coating Technique M. Murata, Y.Minamida, A. Kabir, J. Hino, J. Tazaki, M. Ito, I. Kimura
T. Akazawa, M. Murata, Y.Minamida, A. Kabir, J. Hino, J. Tazaki, M. Ito, I. Kimura
Journal of Hard Tissue Biology   21:351-358    2012
BMPs as Adsorptive Proteins for Ceramic Scaffolds
K. Ito, M. Murata, J. Hino, J. Tazaki, T. Akazawa, M. Arisue.
Key Engineering Materials Vols.   493-494(pp 808-812)    2012
Simultaneous Implantation of Dental Implants and Autogenous Human Dentin
J. Tazaki, M. Murata, Y. Nakanishi, M. Ochi, T. Akazawa, S. Yodogawa, J. Hino, K. Ito, M. Arisue, T. Shibata.
Key Engineering Materials Vols.   493-494 pp 426-429    2012
Characterization of Bio-Absorbable and Biomimetic Apatite/Collagen Composite Powders Derived from Fish Bone and Skin by the Dissolution-Precipitation Method
T. Akazawa, M. Murata, M. Ito, S. Iida, T. Shigyo, T. Nomura, H. Inano, T. Yamagishi, K. Itabashi, K. Nakamura
Key Engineering Materials Vols.   493-494    2012
Multinucleated giant cells for biomaterials - Ceramics and dentin collagen -
M. Murata, T. Akazawa, J. Hino, J. Tazaki, K. Ito, M. Fujii, T. Shibata, M. Arisue.
Key Engineering Materials Vols.   493-494   2012
原田尚樹、柏崎晴彦、赤澤敏之、村田 勝、相沢智康、出村 誠、田中順三、飯塚 正、井上農夫男
32 166-176   2012
Surface structure and biocompatibility of demineralized dentin matrix granules soaked in a stimulated body fluid
T.Akazawa, M. Murata, J. Hino, F.Nagano, T.Shigyo, T.Nomura, H.Inano, K.Itabashi, T.Yamagishi, K.Nakamura, T.Takahashi, S.Iida, H.Kashiwazaki
Applied Surface Science   262 51-55   2012
Qualitative characterization of human bone integrated with midpalatal implant estimated by micro-X-ray diffractometer and histological observation
Masaru Murata, Toshiyuki Akazawa, Toshihiro Yuasa, Miki Okayama, Junichi Tazaki, Takao Hanawa, Makoto Arisue, Itaru Mizoguchi
Applied Surface Science   262 222-226   2012
Acid-insoluble Human Dentin as Carrier Material for Recombinant Human BMP-2
M. Murata, D. Sato, J. Hino, T. Akazawa, J. Tazaki, K. Ito, M. Arisue
J Biomed Mater Res A   100 571-577   2012
Biochemical and histo-morphometrical analyses of bone and cartilage induced by human decalcified dentin matrix and BMP-2
Masaru Murata, Toshiyuki Akazawa, Junichi Hino, Junichi Tazaki, Katsutoshi Ito, Makoto Arisue
Oral Biology Research   35(1) 9-14   2011
Improved bioabsorbability of synthetic hydroxyapatite through partial dissolution-precipitation of its surface
Xianjun Ding, Masahiko Takahata, Toshiyuki Akazawa, Norimasa Iwasaki, Yuichiro Abe, Miki Komatsu, Masaru Murata, Manabu Ito, Kuniyoshi Abumi Akio Minami.
Journal of Materials Science: Materials in Medicine   22(5) 1247-55   2011
Characterization of bio-absorbable and biomimetic apatite/collagen composite powders derived from fish bone and skin by the dissolution-precipitation method
T.Akazawa, M.Murata, M.Ito, S.Iida, T.Shigyo, T.Nomura, H.Inano, T.Yamagishi, K.Itabashi, K.Nakamura
Archives of BioCeramics Research      2011
Characterization of Microstructure and Bio-Absorption of the Hydroxyapatite Ceramics Modified by a Partial Dissolution-Precipitation Technique Using Supersonic Treatment.
Toshiyuki Akazawa, Masaru Murata, Masahiko Takahata, Ding Xianjun, Yuichiro Abe, Katsuo Nakamura, Jun Hino, Junichi Tazaki, Katsutoshi Ito, Manabu Ito, Norimasa Iwasaki, Akio Minami, Takehiko Nakajima, Michiko Sakamoto
Journal of the Ceramic Society of Japan   118(6) 535-540   2010
Autograft of human tooth and demineralized dentin matrices for bone augmentation.
Tazaki J., Murata M., Yuasa T., Akazawa T., Ito K., Hino J., Nida A., Arisue M., Shibata T.
Journal of the Ceramic Society of Japan   118(6) 442-445   2010
In vivo evaluation of a novel chitosan/HAp composite biomaterial as a carrier of rhBMP-2.
H.Kashiwazaki, K.Yamaguchi, N.Harada, T.Akazawa, M.Murata, T.Iizuka, T.Ikoma, J.Tanaka, N.Inoue
Journal of Hard Tissue Biology   19(3) 181-186   2010
Clim.Oral Impl. Res   14(4) 490-499   2003
Expression of BMP receptor and osteopontin mRNA during BMP-induced odontoblast-like cells in vitro (共著)
Dentin/Pulp Complex, Ed Shimono M, Quintesene Publishing Co.   pp.154-156    2002
Combination of recombinant human BMP-2 and atelocollagen implant with cortical perforations for bone augmentation.(共著)
J. Hard Tissue Biology   10 19-24   2001
X-ray scanning analytical microscopic and scanning electron microscopic studies of an unusual case of dens invaginatus.(共著)
Bone healing of large mandibular defects without periosteum in adult rabbits. A new application of collagenous sponge for bone regeneration(共著)
J. Hard Tissue Biology   9 56-62   2000
Combination of recombinant human BMP-2 and atelocollagen implant with cortical perforations for bone augmentation.(共著)
Proceeding of Asian Science Seminer in Okayama 2000      2000
Bone augmentation by onlay implant using recombinant human BMP-2 and collagen on adult rat skull without periosteum (共著)
Clin. Oral Impl. Res   11 289-295   2000
Bone augmentation by recombinant human BMP-2 and collagen on adult rat parietal bone. (共著)
Int. J. Oral Maxillofac. Surg.   28 232-237   1999
Enhancement of experimental pulmonary metastasis and inhibition of subcutaneously transplanted tumor growth following cryosurgery. (共著)
Anticancer Research   18 4443-4448   1998
Carrier-dependency of cellular differentiation induced by bone morphogenetic protein(BMP) in ectopic sites. (共著)
Int. J. Oral Maxillofac. Surg.   27 391-396   1998
J. Jpn. Soc. Oral Implant   11(2) 190-197   1998
Bone morphogenetic protein(BMP) stimulates cytological and functional differentiation of preodontoblasts in vitro. (共著)
J. of Hard Tissue Biology   6(3) 105-113   1997
Aging and ectopic bone formation induced by partially purified bone morphogenetic protein. (共著)
Jpn. J. oral Biol.   39 572-582   1997
Gene expression of amelogenin in adontogenic tumors. (共著)
J. Oral pathology & Medicine   25(5)    1996
Histological and Morphological Study of Bone Formation in Rat Subcutaneous Tissue by BMP-Collagen Particles.(共著)
J. of Hard Tissue Biology   5(3) 188-194   1996
Extraction of Bone proteins and Purification of BMP
51-56   1996
Histopathological and Immunohistochemical Study of Heterotopic Chondro-Osseous Tissue Formation Induced by S-200 BMP(共著)
J.of Hard Tissue Biology   5(1) 1-6   1996
Bone Induction on the surface of hydroxyapatite ceramics.(共著)
Bioceramics.   8 61-67   1995
Immunohistochemical Study of Heterotopic Cartilage-Bone Formation Induced by BMP-FGM(共著)
DENTISTRY IN JAPAN   32 19-21   1995
The Effect of Enzymatic Treatment on Immunohistochemical Staining of Collagens in Mandibular Condyle of Rats.(共著)
J.of Hard Tissue Biology   4(1) 15-23   1995
Bone Induction of Hydroxyapatite Combined with Bone Morphogenetic Protein and Covered with Periosteum.(共著)
Plast.Reconstr.Surg   95(7) 1265-1272   1995
Gene Expression of Bone Matrix Protein mRNA during BMP Induced Chondrogenesis and Osteogenesis by in situ Hybridyzation. (共著)
4 15-23   1995
Two Distinctive BMP-Carriers Induce Zonal Chondrogenesis and Membranous Ossification, Respectively ; Geometrical Factors of Matrices for Cell-differentiation. (共著)
Connective Tissue Research   31(3) 1-8   1995
The Fate of Cartilage Tissue in BMP-FGM Induced Induced Ectopic Bone Formation. (共著)
Proceedings of the 3rd World Congress for Oral Implantology   62-63   1994
Histopathological Studies of Heterotopic Bone Formation Induced by BMP Carrier Composites. (共著)
3 67-72   1994
Journal of Japanese Society of Oral Implantology   7 243-248   1994
Chondro-Osteogenesis Induced after Subcutaneous Implantation of BMP-Nonorganic Carriers. (共著)
Proceedings of 3rd World Congress for Oral Implantology   528-529   1994
Heterotopic Bone Induced by Different BMP-Collagen Carriers. (共著)
Proceedings of 3rd World Congress for Oral Implantology   64-65   1994
Ectopic Bone Induction by BMP.
7 230-236   1994
Phenotype expression of BMP-induced cell differentiation is dependent on the matrix -Direct bone formation in porous hydroxyapatite-
15 148-160   1994
BMPs induce direct bone formation in ectopic sites independent of the endochondral ossification in viro. (共著)
Anatomical Record.   236,373-380    1993
Histological studies of heterotopic osteogenesis induced by bone morphogenetic protein binding Hydroxyapatite. (共著)
Apatite   1 320-330   1992
Hydroxyapatite as a Supporter for Osteoblast differentiation In vivo and In vitro. (共著)
Apatite   1 311-320   1992
Study on Bone Induction in Hydroxyapatite Combined with Bone Morphogenetic Protein. (共著)
Plast. Reconstr. Surg.   90(5) 870-879   1992
Osteogenesis Induced by BMP-Couted Biomaterials : Biochemical principles of Bone Reconstruction in Dentistry. (共著)
The Bone-Biomaterials Interface. J. D. Davies, ed. University of Toronto Press.   127-138    1990
Rapid bone induction of cortical bone treated with ultrasonic demineralization in acidic electrolyzed water.
Shakya, M., Yokozeki, K., Akazawa, T., Murata, M.
Journal of Hard Tissue Biology 27:269-271, 2018   
Microcracks Design and Bone Induction of Skull Bone Modified by Ultrasonic Treatment using Acidic Electrolyzed Water.
Mamata Shakya, Masaru Murata, Naoto Okubo, Hiroki Nagayasu, Toshiyuki Akazawa
Phosphorus Research Bulletin, 33,1-6, 2017   
Characterization of demineralization behavior of bovine bone granules related to particulate properties.
Kimura I, Wei T, Akazawa T, Murata M.
Advanced Powder Technology. 28 (3): 740-746, 2017   
Interface function design and bone-regenerative engineering of biomimetic biomaterials by supersonic treatment using electrolyzed water.
T. Akazawa, M. Murata, Y.Minamida, A.Kabir, M. Ito, A.Katayama, T.Nakajima
Key Engineering Materials Vols.   631(2015) pp 241-246 
Bone induction in porous HAp block modified by partial dissolution-precipitation technique with super sonic treatment in rat scalp
M. Murata, T. Akazawa, Y.Minamida, Md.A.Kabir, J.Hino, H.Nagayasu, M. Ito, M.Sakamoto, T.Nakajima
Key Engineering Materials Vols.   631(2015) pp 430-434 
Highly porous β-TCP block with triple pore structure in rat subcutaneous tissue and sheep iliac critical bone defect.
M. Murata, T. Akazawa, A.Kabir, Y.Minamida, M.Shakya, H.Nagayasu, K.Yamada, M. Ito, M.Sakamoto, T.Matsumoto, T.Nakajima
Key Engineering Materials Vols.   696(2016) pp 187-191 
Interface function and cefazolin-adosorption-release characteristics of hydroxyapatite granules modified by supersonic treatment techniques.
T. Akazawa, M. Murata, Y.Minamida, A.Kabir, M. Ito, M.Sakamoto, T.Nakajima
Key Engineering Materials Vols.   696(2016) pp 265-270 
Demineralized dentin matrix with artificial perforations for bone regeneration in critical defects of adult sheep.
Kabir MA, Murata M, Akazawa T, Yamada K, Ito M, T. Shibata.
Phosphorus Research Bulletin   31,1-3. 2016 
草野 薫,村田 勝,南田康人,佐々木智也, 永易裕樹
日本顎顔面インプラント学会誌   15:25-30,2016 
Knowledge and attitude of oral and labial cancer among adults of Kathmandu.
Mamata Shakya, Akashlynn Badruddoza Dithi, Bhoj Raj Adhikari, Md Riasat Hasan, Nirju Ojha, Masaru Murata.
City Dental College Journal   ISSN: 2305-0039 (Print); ISSN: 
Retrospective clinical study of allogenic demineralized dentin matrix for alveolar bone repair.
Young-Kyun Kim, Kang-Mi Bang, Masaru Murata, Masaharu Mitsugi, In-Woong Um
Journal of Hard Tissue Biology   26:95-102, 2017 
Evaluation of perforated demineralized dentin scaffold on bone regeneration in critical-size sheep iliac defects.
Kabir MA, Murata M, Akazawa T, Kusano K, Yamada K, Ito M.
Clin Oral Implants Res. 28(11):e227-e235, 2017   

Books etc

Extraction of Bone matrix proteins and Purification of BMP.
New technology of molecular mechanism research in morphogenesis   1998   


Development of GTR membrane using DNA-collagen-bone matrix composite
Regeneration of periodontal tissue by BMP-applied DNA/atelocollagen sponge.

Research Grants & Projects

Biological bone regeneration by Bone morphogenetic protein.
Development and application of DNA-collagen sponge
Development of bioabsorbable apatite
Research on Bone regeneration
Research on Biomaterials