2004年7月
Immunolocalization of vascular endothelial growth factor in rat condylar cartilage during postnatal development
HISTOCHEMISTRY AND CELL BIOLOGY
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- 巻
- 122
- 号
- 1
- 開始ページ
- 35
- 終了ページ
- 40
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1007/s00418-004-0671-3
- 出版者・発行元
- SPRINGER
It is well known that angiogenesis is essential for the replacement of cartilage by bone during skeletal growth and regeneration. To address angiogenesis of endochondral ossification in the condyle, we examined the appearance of vascular endothelial growth factor (VEGF) and its receptor Flt-1 in condylar cartilage of the growing rat. The early expression of VEGF at various sites during condylar cartilage development indicates that VEGF plays a role in the regulation of angiogenesis at each site of bone formation. From the findings of Flt-1 immunoreactivity, the VEGF produced by the chondrocytes of the hypertrophic zone should contribute to the promotion of endothelial cell proliferation and to stimulate migration and activation of osteoclasts in condylar cartilage, resulting in the invasion of these cells into the mineralized zone.
- リンク情報
- ID情報
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- DOI : 10.1007/s00418-004-0671-3
- ISSN : 0948-6143
- Web of Science ID : WOS:000222864300005