2003年3月
Effects of repeated stress on regeneration of serotonergic and noradrenergic axons in the cerebral cortex of adult rats
NEUROSCIENCE LETTERS
- ,
- ,
- ,
- 巻
- 339
- 号
- 3
- 開始ページ
- 227
- 終了ページ
- 230
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/S0304-3940(03)00014-4
- 出版者・発行元
- ELSEVIER SCI IRELAND LTD
We examined whether regeneration of serotonergic (5-HT) and noradrenergic (NA) axons might be affected by stress. Neurotoxins to 5-HT or NA axons were injected into the frontal cortex to cause partial denervation. Mild restraint stress (40 min/day) was started 16 days later and given for 14 consecutive days (30-day stressed group). Non-stressed animals were divided into two groups, animals sacrificed at 14 days (14-day control group) and those sacrificed at 30 days (30-day control group) after the toxin injection. In immunohistochemical study, the denervation area of 5-HT axons but not that of NA axons was significantly smaller in the 30-day control group than in the 14-day control group. However, there was no significant difference between the 14-day control and 30-day stressed groups. These findings suggested that regeneration of 5-HT axons occurred earlier than that of NA axons, and that stress exerted inhibitory influence on regeneration of 5-HT axons. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/S0304-3940(03)00014-4
- ISSN : 0304-3940
- Web of Science ID : WOS:000181641600014