Feb, 1994
INDUCTION OF BILIRUBIN UDP-GLUCURONOSYLTRANSFERASE AND CYP4A1 P450 BY COPLANAR PCBS - DIFFERENT RESPONSIVENESS OF GUINEA-PIGS AND RATS
CHEMOSPHERE
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- Volume
- 28
- Number
- 3
- First page
- 639
- Last page
- 645
- Language
- English
- Publishing type
- Research paper (scientific journal)
- DOI
- 10.1016/0045-6535(94)90305-0
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
Induction of hepatic microsomal bilirubin UDP-glucuronyltransferase and CYP4A1 P450 by 3,4,3',4'-tetrachlorobiphenyl (TCB) and 3,4,5,3',4'-pentachlorobiphenyl (PenCB) was studied in guinea pigs and rats. Both enzyme activities in guinea pigs were increased 4-fold or more over the control by PenCB treatment, while by treatment with a less toxic congener, TCB, these were increased to a lesser extent. On the contrary, the rat enzymes were significantly decreased by treatment with these co-planar polychlorinated biphenyls. These results suggest that the alterations of both bilirubin UDP-glucuronyltransferase and CYP4A P450 are the characteristic indices for the toxicities of polychlorinated hydrocarbons.
- Link information
- ID information
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- DOI : 10.1016/0045-6535(94)90305-0
- ISSN : 0045-6535
- CiNii Articles ID : 80007495687
- Web of Science ID : WOS:A1994MZ35000017