Aug, 1999
CYP2A6 gene deletion reduces susceptibility to lung cancer
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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- Volume
- 261
- Number
- 3
- First page
- 658
- Last page
- 660
- Language
- English
- Publishing type
- Research paper (scientific journal)
- DOI
- 10.1006/bbrc.1999.1089
- Publisher
- ACADEMIC PRESS INC
CYP2A6 is an enzyme with a high ability to activate a nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), to its potent and ultimate carcinogen. In the present study, we investigated the relationship between genetic polymorphism of CYP2A6 and lung cancer risk in a case-control study of Japanese subjects. Genotyping of the CYP2A6 gene in both healthy volunteers and lung cancer patients was conducted. The frequency with which the subjects carried homozygotes of the CYP2A6 gene deletion-type mutation (deletion), which causes lack of the enzyme activity, was lower in the lung cancer patients than in the healthy control subjects. The odds ratio (OR) of the group homozygous for the deletion was significantly lower and calculated to be 0.25 (95% CI; 0.08-0.83) when the OR for the population with homozygotes of the CYP2A6 wild-type gene was defined as 1.00, In the allelic-base analysis, there was also a significant decrease in the OR for the deletion allele, These data suggest that deficient CYP2A6 activity due to genetic polymorphism reduces lung cancer risk. (C) 1999 Academic Press.
- Link information
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- DOI
- https://doi.org/10.1006/bbrc.1999.1089
- CiNii Articles
- http://ci.nii.ac.jp/naid/30017796160
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/10441482
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000082014900020&DestApp=WOS_CPL
- ID information
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- DOI : 10.1006/bbrc.1999.1089
- ISSN : 0006-291X
- CiNii Articles ID : 30017796160
- Pubmed ID : 10441482
- Web of Science ID : WOS:000082014900020