論文

査読有り
2002年4月

CYP2A6 gene deletion reduces oral cancer risk in betel quid chewers in Sri Lanka

CARCINOGENESIS
  • Z Topcu
  • ,
  • Chiba, I
  • ,
  • M Fujieda
  • ,
  • T Shibata
  • ,
  • N Ariyoshi
  • ,
  • H Yamazaki
  • ,
  • F Sevgican
  • ,
  • M Muthumala
  • ,
  • H Kobayashi
  • ,
  • T Kamataki

23
4
開始ページ
595
終了ページ
598
記述言語
英語
掲載種別
研究論文(学術雑誌)
出版者・発行元
OXFORD UNIV PRESS

We investigated the relationship between inter-individual difference in CYP2A6 genotype and susceptibility to oral cancer among habitual betel quid chewers in a Sri Lanka population. A total of 286 subjects showing oral malignant or premalignant lesions and 135 control subjects with no lesions were analyzed. The frequency of homozygotes for CYP2A6*4C mutation, a gene deletion type of polymorphism, was significantly lower in the case subjects than the controls. The odds ratio (OR) of the group homozygous for the deletion was significantly lower and calculated to be 0.14 (95% CI; 0.03-0.72). In the allelic base analysis, there was also a significant decrease in the OR of the deletion allele. Our data suggest that deficient CYP2A6 activity due to genetic polymorphism reduces oral cancer risk in betel quid chewers.

リンク情報
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000175163500008&DestApp=WOS_CPL
ID情報
  • ISSN : 0143-3334
  • Web of Science ID : WOS:000175163500008

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