Takehiko Koji

Profile Information

Affiliation: Professor,Others(describe your title), Graduate School of Biomedical Sciences, Medical and Dental Sciences, Nagasaki University

Degree: Doctor of Science

J-GLOBAL ID: 200901034641450138
researchmap Member ID: 1000164547

External link: http://www.med.nagasaki-u.ac.jp/anatomy3/

Research Areas

Life sciences / Anatomy /

Research History

Jun, 2021 - Present

名誉教授, 長崎大学
Apr, 2021 - Present

特命教授, 長崎大学
Apr, 2021 - Present

機構長特別補佐, 研究開発推進機構, 長崎大学
Oct, 2014 - Present

連携会員, 日本学術会議
Sep, 2012 - Present

Visiting Professor, Health Science University of Mongolia (Monglia)
Jun, 2006 - Present

Honorary Preofessor, South-Central University (China)
May, 2006 - Present

Guest Professor, Fujian Medical University (China)
Apr, 2002 - Mar, 2021

Professor and Chairman, Department of Histology and Cell Biology, Nagasaki University Graduate School of Biomedical Sciences
Sep, 1998 - Mar, 2021

Professor and Chairman, Department of Histology and Cell Biology, Nagasaki University School of Medicine
Oct, 2011 - Mar, 2015

Dean, Graduate School of Biomedical Sciences, Nagasaki University
Apr, 2009 - Sep, 2011

Graduate School of Biomedical Sciences, Nagasaki University
Oct, 2006 - Sep, 2011

Vice President（International）, Nagasaki University
Apr, 2005 - Sep, 2011

学部長補佐, 医学部, 長崎大学
Apr, 2005 - Sep, 2011

Director, International Student Center, Nagasaki University
Apr, 1993 - Aug, 1998

Associate Professor, Department of Histology and Cell Biology,, Nagasaki University School of Medicine
Feb, 1993 - Mar, 1993

Assistant Professor, Department of Histology and Cell Biology, Nagasaki University School of Medicine
Mar, 1991 - Jan, 1993

Visiting Scientist, Molecular Endocrinology, Oregon Regional Primate Research Center, USA
Aug, 1989 - Mar, 1991

Assistant Professor, Department of Histology and Cell Biology, Nagasaki University School of Medicine
Apr, 1989 - Jul, 1989

Assistant Professor, Department of Cell Biology, Tokai University School of Medicine
Jan, 1984 - Mar, 1989

Instructor, Department of Cell Biology, Tokai University School of Medicine

Education

Apr, 1980 - Mar, 1983

Graduate School of Science（Ph. D.）, University of Tokyo
Apr, 1978 - Mar, 1980

Graduate School of Science（M.Sc.）, University of Tokyo
Apr, 1974 - Mar, 1978

Faculty of Science, The University of Tokyo

Committee Memberships

Jan, 2016 - Present

Editor-in-Chief (Asia Pacific), Histochemistry and Cell Biology
Jan, 2014 - Present

編集委員, Acta Histochemica et Cytochemica
Feb, 2010 - Present

特約編委, 中華人民共和国海峡予防医学雑誌
Mar, 2006 - Present

理事, NPO法人日本・ミャンマー医療人育成支援協会
Sep, 1998 - Present

代議員, 日本解剖学会
Jan, 1997 - Present

評議員, 日本組織細胞化学会
Apr, 1996 - Present

評議員, 日本臨床分子形態学会（元日本臨床電子顕微鏡学会）
Oct, 1988 - Present

世話人, 分子病理学研究会
Sep, 2019 - Mar, 2021

副理事長, 日本臨床分子形態学会
Apr, 2019 - Mar, 2021

九州支部長, 日本解剖学会
Jan, 2002 - Dec, 2020

理事, 日本組織細胞化学会
Apr, 2016 - Mar, 2020

共同利用・共同研究運営協議会委員, 神戸大学バイオシグナル総合研究センター
Jan, 2014 - Dec, 2019

理事長, 日本組織細胞化学会
Oct, 2008 - Sep, 2019

常任理事（長期計画担当－2021年3月まで）, 日本臨床分子形態学会
Sep, 2005 - Aug, 2019

理事, 日本臨床分子形態学会
May, 2015 - May, 2017

副会長（代表理事）, 日本顕微鏡学会
May, 2013 - May, 2017

理事, 日本顕微鏡学会
May, 2006 - Jun, 2016

委員（2014-2016 副委員長）, 長崎県研究事業評価委員会
Jan, 2002 - Dec, 2015

編集委員, Histochemistry and Cell Biology
Aug, 2009 - Jun, 2015

理事, 日本Cell Death学会

Awards

Papers

362

The Transfer of the Hepatocyte Growth Factor Gene by Macrophages Ameliorates the Progression of Peritoneal Fibrosis in Mice.

Yoko Obata, Katsushige Abe, Masanobu Miyazaki, Takehiko Koji, Yasuhiko Tabata, Tomoya Nishino

International journal of molecular sciences, 24(8), Apr 9, 2023
Transcriptome profiling of anhidrotic eccrine sweat glands reveals that olfactory receptors on eccrine sweat glands regulate perspiration in a ligand-dependent manner

Naoya Murayama, Takafumi Miyaki, Daisuke Okuzaki, Yasuaki Shibata, Takehiko Koji, Asuka Inoue, Junken Aoki, Hideki Hayashi, Yoshimasa Tanaka, Hiroyuki Murota

JID Innovations, 3(4) 100196-100196, Mar, 2023
An Advanced Detection System for In Situ Hybridization Using a Fluorescence Resonance Energy Transfer-based Molecular Beacon Probe

Narantsog Choijookhuu, Yasuaki Shibata, Takumi Ishizuka, Yan Xu, Takehiko Koji, Yoshitaka Hishikawa

Acta Histochemica et Cytochemica, 55(5) 119-128, Oct 25, 2022 Peer-reviewed
Hydroxychloroquine suppresses anti-GBM nephritis via inhibition of JNK/p38 MAPK signaling.

Miki Torigoe, Yoko Obata, Hiro Inoue, Kenta Torigoe, Akira Kinoshita, Takehiko Koji, Hiroshi Mukae, Tomoya Nishino

Clinical and experimental nephrology, 27(2) 110-121, Oct 20, 2022
Compounds in cigarette smoke induce EGR1 expression via the AHR, resulting in apoptosis and COPD.

Naoko Hattori, Takeya Nakagawa, Mitsuhiro Yoneda, Hiromi Hayashida, Kaori Nakagawa, Kazuo Yamamoto, Myo Win Htun, Yasuaki Shibata, Takehiko Koji, Takashi Ito

Journal of biochemistry, Oct 6, 2022
In focus in HCB: new histochemical insights into mammalian gametogenesis

Yoshitaka Hishikawa, Toshihiro Takizawa, Takehiko Koji

Histochemistry and Cell Biology, 157(3) 269-271, Mar, 2022 Last authorCorresponding author
Nuclear expression of Pygo2 correlates with poorly differentiated state involving c-Myc, PCNA and Bcl9 in Myanmar hepatocellular carcinoma.

Myo Win Htun, Shibata Y, Kyaw Soe, Koji T

Acta Histochem Cytochem, 54(6) 195-206, Dec, 2021 Peer-reviewedLast author
Mitochonic acid-5 ameliorates chlorhexidine gluconate-induced peritoneal fibrosis in mice

Hiro Inoue, Kenta Torigoe, Miki Torigoe, Kumiko Muta, Yoko Obata, Takehiro Suzuki, Chitose Suzuki, Takaaki Abe, Takehiko Koji, Hiroshi Mukae …

Medical Molecular Morphology, 55(1) 27-40, Oct 7, 2021
An inhibitor of Krüppel-like factor 5 suppresses peritoneal fibrosis in mice.

Kumiko Muta, Yuka Nakazawa, Yoko Obata, Hiro Inoue, Kenta Torigoe, Masayuki Nakazawa, Katsushige Abe, Akira Furusu, Masanobu Miyazaki, Kazuo Yamamoto …

Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, 41(4) 394-403, Jul, 2021 Peer-reviewed
Mitochonic Acid 5はクロルヘキシジングルコン酸塩誘発性マウス腹膜線維化を抑制する

井上大, 鳥越健太, 牟田久美子, 小畑陽子, 鈴木健弘, 鈴木千登世, 阿部高明, 小路武彦, 西野友哉

日本腎臓学会誌, 63(4) 516-516, Jun, 2021
Mitochonic Acid 5はクロルヘキシジングルコン酸塩誘発性マウス腹膜線維化を抑制する

井上大, 鳥越健太, 牟田久美子, 小畑陽子, 鈴木健弘, 鈴木千登世, 阿部高明, 小路武彦, 西野友哉

日本腎臓学会誌, 63(4) 516-516, Jun, 2021
Vitamin K-Dependent γ-Glutamyl Carboxylase in Sertoli Cells Is Essential for Male Fertility in Mice.

Sachiko Shiba, Kazuhiro Ikeda, Kuniko Horie-Inoue, Kotaro Azuma, Tomoka Hasegawa, Norio Amizuka, Tomoaki Tanaka, Toshihiko Takeiwa, Yasuaki Shibata, Takehiko Koji …

Molecular and Cellular Biology, 41(4), Mar 24, 2021 Peer-reviewed
ヒドロキシクロロキンは抗GBM抗体腎炎の進展を抑制する

鳥越未来, 小畑陽子, 井上大, 鳥越健太, 木下晃, 小路武彦, 西野友哉

日本腎臓学会誌, 62(4) 310-310, Jul, 2020
Mitochonic Acid 5(MA-5)はCG誘発性マウス腹膜線維化を抑制する

井上大, 小畑陽子, 鈴木健弘, 鳥越未来, 鳥越健太, 鈴木千登世, 阿部高明, 小路武彦, 西野友哉

日本腎臓学会誌, 62(4) 313-313, Jul, 2020
ヒドロキシクロロキンは抗GBM抗体腎炎の進展を抑制する

鳥越未来, 小畑陽子, 井上大, 鳥越健太, 木下晃, 小路武彦, 西野友哉

日本腎臓学会誌, 62(4) 310-310, Jul, 2020
Mitochonic Acid 5(MA-5)はCG誘発性マウス腹膜線維化を抑制する

井上大, 小畑陽子, 鈴木健弘, 鳥越未来, 鳥越健太, 鈴木千登世, 阿部高明, 小路武彦, 西野友哉

日本腎臓学会誌, 62(4) 313-313, Jul, 2020
Global changes in epigenomes during mouse spermatogenesis: possible relation to germ cell apoptosis.

Koji T, Shibata Y

154(2) 123-134, Jul, 2020 Peer-reviewedInvitedLead author
Hexapeptide derived from prothymosin alpha attenuates cisplatin-induced acute kidney injury

Kenta Torigoe, Yoko Obata, Miki Torigoe, Satoru Oka, Kazuo Yamamoto, Takehiko Koji, Hiroshi Ueda, Hiroshi Mukae, Tomoya Nishino

Clinical and experimental nephrology, 24(5) 411-419, Jan, 2020 Peer-reviewed
Dahl食塩感受性ラットの腎間質線維化におけるCD47-SIRPα系の関与

井上大, 小畑陽子, 鳥越未来, 鳥越健太, 小路武彦, 西野友哉

日本腎臓学会誌, 61(3) 329-329, May, 2019 Peer-reviewed
Evaluation of Candida peritonitis with underlying peritoneal fibrosis and efficacy of micafungin in murine models of intra-abdominal candidiasis.

Ashizawa N, Miyazaki T, Abe S, Takazono T, Saijo T, Obata Y, Shimamura S, Yamamoto K, Imamura Y, Koji T …

Sci Rep, 9(1) 9331, 2019 Peer-reviewed

Misc.

329

Differences in physiological activities associated with plasma membranes between liver and hepatoma cells:with special reference to the control of cell proliferation

Yamagami Keiji, Koji Takehiko, Terayama Hiroshi

MEMBRANE, 6(7) 442-448, 1981 Peer-reviewed
内分泌細胞の免疫組織化学的in situ hybridization。

中根一穂, 守内哲也, 小路武彦

東洋薬事報, 26(12) 7-12, 1985 Invited
ENZYME-IMMUNO-HISTO INSITU HYBRIDIZATION (EIHISH) - CELL AND TISSUE-PREPARATION

T KOJI, T MORIUCHI, PK NAKANE

ZOOLOGICAL SCIENCE, 2(6) 899-899, 1985
BACKSCATTERED ELECTRON IMAGING OF HISTOCHEMICALLY STAINED CELLS AND TISSUE-SECTIONS ON GLASS SLIDES

S IZUMI, T KOJI, T MORIUCHI, PK NAKANE

ACTA HISTOCHEMICA ET CYTOCHEMICA, 18(6) 645-645, 1985
ENZYME-IMMUNO-HISTO INSITU HYBRIDIZATION (EIHISH) - PREPARATION OF SPECIMENS

T KOJI, T MORIUCHI, PK NAKANE

CELL STRUCTURE AND FUNCTION, 10(4) 497-497, Dec, 1985
Enzyme-immuno-histo in situ hybridization.

Nakane PK, Moriuchi T, Koji T

44(3) 638-644, 1986 Invited
In situ ハイブリダイゼーションによるmRNAの検出法（細胞生物学実験マニュアル）。

小路武彦, 中根一穂

生体の化学, 37(4) 435-437, 1986 Invited
EIHISH (Enzyme-immuno-Histo in situ hybridization).

Nakane PK, Moriuchi T, Koji T

34(6) 477-482, 1986 Invited
ハプテン標識DNA probeを用いたHisto In Situ Hybridization法。

小路武彦, 中根一穂

細胞, 18(6) 224-228, 1986 Invited
Hapten標識cDNAを用いてのin situ hybridization法によるmRNAの検出；組織標本作製条件を中心として。

小路武彦, 守内哲也, 中根一穂

細胞, 18(8) 305-309, 1986 Invited
In situ hybridization 新しい技術を用いた組織化学検出法。

小路武彦, 守内哲也, 中根一穂

医学のあゆみ, 139(8) 592-593, 1986 Invited
LOCALIZATION OF C-MYC MESSENGER-RNA BY INSITU HYBRIDIZATION IN NORMAL AND NEOPLASTIC TISSUE-SECTIONS USING NONRADIOACTIVE DNA PROBES

T KOJI, M TANNO, T MORIUCHI, PK NAKANE

ACTA HISTOCHEMICA ET CYTOCHEMICA, 19(3) 391-391, 1986
Enzyme-immuno-histo in situ hybridization。（腫瘍における生理活性物質の産生とその機序）

中根一穂, 守内哲也, 小路武彦

癌と化学療法, 13(3) 740-746, 1986 Invited
第2回US Japan Histochemistry and Cytochemistry Congressに参加して。

小路武彦

実験医学, 4(8) 764-765, 1986 Invited
THYMINE-THYMINE (T-T) DIMERIZED DNA AS PROBE FOR SOUTHERN, NORTHERN AND INSITU HYBRIDIZATION

PK NAKANE, T MORIUCHI, M TANNO, T KOJI

JOURNAL OF CELL BIOLOGY, 103(5) A517-A517, Nov, 1986
COMPLETE NUCLEOTIDE-SEQUENCE OF CDNA AND DEDUCED AMINO-ACID-SEQUENCE OF RAT PCNA CICLIN

T MORIUCHI, K MATSUMOTO, T KOJI, PK NAKANE

CELL STRUCTURE AND FUNCTION, 11(4) 524-524, Dec, 1986
EXPRESSION OF C-MYC IN SYNCHRONIZED HL-60 CELLS - INSITU HYBRIDIZATION AND IMMUNOHISTOCHEMICAL STUDIES

M TANNO, T KOJI, T MORIUCHI, S IZUMI, PK NAKANE

CELL STRUCTURE AND FUNCTION, 11(4) 499-499, Dec, 1986
組織免疫法へのハプテン標識DNAプローブの応用。

中根一穂, 守内哲也, 小路武彦

蛋白質・核酸・酵素, 別冊31 286-292, 1987 Invited
In situ hybridization法によるProopiomelano-cortin nRNAの局在証明。

小路武彦, 守内哲也, 中根一穂

実験医学, 5(2) 171-173, 1987 Invited
胸腺腫並びに胸腺におけるc-myc mRNAのenzyme-immuno-histo-in situ-hybridization (EIHISH)。

有森茂, 吉田美代子, 守内順子, 中根一穂, 守内哲也, 小路武彦

医学と生物学, 115(2) 55-56, 1987

Books and Other Publications

102

In situ hybridization法の原理と応用。[組織細胞化学2021]（日本組織化学会編）

菱川善隆, 柴田恭明, 小路武彦 (Role: Joint author, pp. 107-120)

日本組織細胞化学会, Aug, 2021
In situ hybridization法の原理と応用。[組織細胞化学2020]（日本組織化学会編）

菱川善隆, 柴田恭明, 小路武彦 (Role: Joint author, pp. 107-121)

日本組織細胞化学会, Aug, 2020
in situ ハイブリダイゼーション法とその応用。[ライフサイエンス顕微鏡学ハンドブック]（山科正平、高田邦昭責任編集／牛木辰男、臼倉治郎、岡部繁男、高松哲郎、寺川進、藤本豊士編）

小路武彦 (Role: Joint author, pp.101-106)

朝倉書店, Jan, 2018 (ISBN: 9784254310948)
In situ hybridizationの原理と実際。[組織細胞化学2016]（日本組織化学会編）

小路武彦 (Role: Joint author, pp.67-78)

学際企画, Jul, 2016 (ISBN: 9784906514908)
組織細胞化学の新たな挑戦。[組織細胞化学2015]（日本組織化学会編）

小路武彦 (Role: Joint author, pp.119-130)

学際企画, Jul, 2015 (ISBN: 9784906514885)
In situ ハイブリダイゼーションの原理と基礎。[組織細胞化学2014]（日本組織細胞化学会編）

遠藤大輔, 小路武彦 (Role: Joint author, pp.75-88)

学際企画, Jul, 2014 (ISBN: 9784906514854)
組織化学が描く未来像。[組織細胞化学2014]（日本組織化学会編）

小路武彦 (Role: Joint author, pp.115-125)

学際企画, Jul, 2014 (ISBN: 9784906514854)
組織化学的アプローチによる転写調節解析：転写調節因子とエピジェネティック因子の局在証明法。［組織細胞化学2013］（日本組織細胞化学会編）

小路武彦 (Role: Joint author, pp.77-88)

学際企画, Jul, 2013 (ISBN: 9784906514823)
［カラーアトラス機能組織学（原著第二版）］（Jeffrey B Kerr著／河田光博、小路武彦監訳）

小路武彦 (Role: Joint translator)

医歯薬出版, Jan, 2013 (ISBN: 9784263731468)
In situ ハイブリダイゼーションの原理と実践。［組織細胞化学2012］（日本組織細胞化学会編）

遠藤大輔, 小路武彦 (Role: Joint author, pp.59-72)

学際企画, Jul, 2012 (ISBN: 9784906514816)
HELMET (histo-endonuclease-linked detection of methylation sites of DNA)法によるDNAメチル化部位の視覚化。[モノグラフ病気の分子形態学]（日本臨床分子形態学会編）

小路武彦 (Role: Joint author, pp.70-72)

学際企画, Oct, 2011 (ISBN: 9784906514809)
In situ hybridization。[モノグラフ病気の分子形態学]（日本臨床分子形態学会編）

菱川善隆, 小路武彦 (Role: Joint author, pp.66-69)

学際企画, Oct, 2011 (ISBN: 4906514804)
In situ ハイブリダイゼーションの基礎と応用。［組織細胞化学2011］（日本組織細胞化学会編）

小路武彦 (Role: Joint author, pp.63-75)

学際企画, Jul, 2011 (ISBN: 9784906514793)
In situ nick translation (ISNT)法。[実験医学別冊細胞死実験プロトコール]（刀祢重信、小路武彦編）

小路武彦 (Role: Joint editor, pp.59-64)

羊土社, Jun, 2011 (ISBN: 9784758101813)
TUNEL法。[実験医学別冊細胞死実験プロトコール]（刀祢重信、小路武彦編）

小路武彦 (Role: Joint editor, pp.52-58)

羊土社, Jun, 2011 (ISBN: 9784758101813)
転写調節解析への組織化学アプローチ：転写因子とDNAメチル化部位の局在証明法。［組織細胞化学2010］（日本組織細胞化学会編）

小路武彦 (Role: Joint author, pp.61-70)

中西印刷, Jul, 2010 (ISBN: 4906514758)
In situ ハイブリダイゼーションの基礎と応用。［組織細胞化学2010］（日本組織細胞化学会編）

菱川善隆, 小路武彦 (Role: Joint author, pp.47-60)

中西印刷, Jul, 2010 (ISBN: 9784906514755)
永遠の不死ー精子形成細胞の生物学ー。［新・生命科学ライブラリ－医学とバイオ6］（小路武彦編著）

小路武彦

サイエンス社, Feb, 2009 (ISBN: 9784781912202)
遺伝子と蛋白質合成。［標準細胞生物学］（石川春律監修、近藤尚武、柴田洋三郎、藤本豊士、溝口明編集）

小路武彦 (Role: Joint author, pp.24-49)

医学書院, Feb, 2009 (ISBN: 9784260003933)
In situ ハイブリダイゼーションの基礎と応用。［組織細胞化学2008］（日本組織細胞化学会編）

菱川善隆, 小路武彦 (Role: Joint author, pp35-49)

中西印刷, Jul, 2008 (ISBN: 9784906514700)

Presentations

773

ミャンマー人肝細胞がん分化型低下に伴うPygo2及びc-Mycの相関的な発現上昇。

柴田恭明, Myo Win Htun, 小路武彦

第127回日本解剖学会総会・全国学術集会（WEB開催）, Mar 28, 2022
Microscopic analysis of "Grundnorm" in life science; from genome to epigenome.

Nov 24, 2021 Invited
Nuclear expression of Pygo2 and Bcl9 complex correlates that of c-Myc and PCNA in Myanmar hepatocellular carcinoma.

Myo Win Htun, Myat, Shibata, Y, Koji, T

Oct 22, 2021
蛍光共鳴エネルギー移動（FRET）を利用したin situ hybridizationの実際。

菱川善隆, Choijookhuu, N, 石塚匠, 柴田恭明, 小路武彦

第61回日本組織細胞化学会総会・学術集会（WEB開催）, Sep 25, 2021 Invited
In situ PCRを用いたマウス雄性生殖細胞に於けるPgk-1、-2遺伝子のinter-chromosomal interaction解析。

柴田恭明, 小路武彦

第126回日本解剖学会総会・全国学術集会（WEB開催）, Mar 28, 2021
The two Bcl9 antibodies that recognize different epitopes immunohistochemically characterize juvenile development of HCC in Myanmar.

Myo Win Htun, Myat Thu Soe, Shibata, Y, Abe, K, Koji, T

第61回日本組織細胞化学会総会・学術集会（WEB開催）, Dec 7, 2020
分子組織細胞化学の開拓と展開。

小路武彦

第61回日本組織細胞化学会総会・学術集会（WEB開催）, Dec 7, 2020 Invited
DES依存性マウス下垂体ゴナドトロフからPRL細胞への分化転換にはヒストンH3K9の脱アセチル化が関与する。

柴田恭明, Myo Win Htun, 小路武彦

第52回日本臨床分子形態学会総会・学術集会（WEB開催）, Dec 3, 2020
2つのBcl9抗体を用いたミャンマー国肝細胞がんの分別的免疫組織化学：若年性肝細胞がんにおける細胞内Bcl9発現の低下。

柴田恭明, Myo Win Htun, 小路武彦

第62回日本顕微鏡学会九州支部集会・学術講演会（WEB開催）, Nov 14, 2020
Localization of c-Myc, CD163 and NF-κB positive macrophages in the iron overload rat liver after partial hepatectomy.

Myo Win Htun, Shibata, Y, Koji, T

Nov 14, 2020
超解像顕微鏡による細胞内タンパク質凝集体の形態解析。

松本弦, 柴田恭明, 小路武彦

第62回日本顕微鏡学会九州支部集会・学術講演会（WEB開催）, Nov 14, 2020
Mitochonic acid 5 alleviates chlorhexidine gluconate-induced peritoneal fibrosis in mice.

Inoue H, Obata Y, Suzuki T, Torigoe M, Torigoe K, Muta K, Suzuki C, Abe T, Koji T, Nishino T

ASN KIDNEY WEEK 2020（WEB開催）, Oct, 2020
Juvenile development of HCC in Myanmar is immunohistochemically characterized by the two Bcl9 antibodies that recognize different epitopes.

Myo Win Htun, Myat Thu Soe, Shibata, Y, Abe, K, Koji, T

Oct 24, 2020
Mitochonic Acid 5(MA-5)はCG 誘発性マウス腹膜線維化を抑制する。

井上大, 小畑陽子, 鈴木健弘, 鳥越未来, 鳥越健太, 鈴木千登世, 阿部高明, 小路武彦, 西野友哉

第63回日本腎臓学会学術総会（WEB開催）, Aug, 2020
ヒドロキシクロロキンは抗GBM抗体腎炎の進展を抑制する。

鳥越未来, 小畑陽子, 井上大, 鳥越健太, 木下晃, 小路武彦, 西野友哉

第63回日本腎臓学会学術総会（WEB開催）, Aug, 2020
Mitochonic acid 5(MA-5) ameliorates Cg-induced peritoneal fibrosis in mice.

Inoue, H, Obata, Y, Suzuki, T, Torigoe, M, Torigoe, K, Suzuki, C, Abe, T, Koji, T, Nishino, T

57th ERA-EDTA Congress（WEB開催）, Jun, 2020
Hydroxychloroquine prevents anti-GBM glomerulonephritis in rats.

Torigoe M, Obata Y, Inoue H, Torigoe K, Kinoshita A, Koji T, Nishino T

57th ERA-EDTA Congress（WEB開催）, Jun, 2020
神経選択的転写抑制因子REST/NRSFタンパク質の不活性化機構の解析。

村井清人, 大村晃太郎, 淵野萌子, 森望, 弦本敏行, 小路武彦, 松本弦

第125回日本解剖学会総会・全国学術集会（WEB開催）, Mar 27, 2020
HDAC阻害剤はDiethylstilbestrolによる性腺刺激ホルモン産生細胞からプロラクチン分泌細胞への分化転換を抑制する。

柴田恭明, Nandar Tun, Myat Thu Soe, Myo Win Htun, 小路武彦

第125回日本解剖学会総会・全国学術集会（WEB開催）, Mar 27, 2020
胎内低栄養環境エピゲノム変化に関連する消化吸収機構の解明と生活習慣病。

藤田守, 馬場良子, 都合亜記暢, 國分啓司, 森本景之, 中村桂一郎, 小路武彦

第51回日本臨床分子形態学会総会・学術集会, Sep 20, 2019

Professional Memberships

Works

Research Projects

Structure and function of spermatocyte nucleolus in the meiotic prophase; electron microscopic and molecular anatomical analysis

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2020 - Mar, 2023
網羅的発現解析が明らかにした眼特異的転写産物は角膜再生の新規キープレーヤーか？

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2019 - Mar, 2022

木下晃, 小路武彦
Local differences in juvenile development of hepatocellular carcinoma in multi-racial Myanmar; focusing on the effect of iron and arsenic

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

KOJI Takehiko, Kyaw Soe, Kyaw Myat Phone, Kyaw Zin Thant
Effect of epigenetic aberrations on germ cells and interchromosomal coordination of gene expression in mouse spermatogenesis

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2018

KOJI Takehiko
mitochondrial multipotent functions regulated by estrogen receptor

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2009 - 2011

HISHIKAWA Yoshitaka, SATO Yoko, KOJI Takehiko
Analysis of the transition mechanism from mitosis to meiosis on spermatogenic cells by using cybrid model.

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2009 - 2011

SATO Yoko, KOJI Takehiko
Involvement of environmental iron in juvenile development of virus-related liver cancer in Myanmar

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2007 - 2009

KOJI Takehiko, HISHIKAWA Yoshitaka, AN Shucai, SATO Yoko, IZUMI Shinichi, ABE Kuniko
Molecular analysis of epigenetic factors involved in the induction of spermatogenic cell apoptosis

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2006 - 2008

KOJI Takehiko, HISHIKAWA Yoshitaka, IZUMI Shinichi, AN Shucai, SATO Yoko
CELL-BIOLOGICAL AND GRAPHIC STUDIES OF GROWTH DISTURBANCE AND SCLEROTIC CHANGE OF MASTOID AIR CELLS

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2006 - 2007

TAKAHASHI Haruo, KOUJI Takehiko, FUKUDA Tomomi, UMEKI Hiroshi, FUJIYAMA Daisuke
Effect of iron as an environmental poisonous compound upon the precocious development of human hepatocellular carcinoma in Myanmar

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2004 - 2006

KOJI Takehiko, HISHIKAWA Yoshitaka, AN Sucai, IZUMI Shinichi, OKADA Shigeru
マウス雄性生殖幹細胞の培養系樹立への新奇アプローチ

科学研究費助成事業萌芽研究, 萌芽研究, 日本学術振興会, 2004 - 2005

小路武彦, 杉本幸隆
Molecular mechanisms of the induction of spermatogenic cell apoptosis through mitochondria

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2003 - 2005

KOJI Takehiko, HISHIKAWA Yoshitaka, EJIMA Kuniaki, IZUMI Shinichi
Molecular Histo-cytochemical Analysis of Gene Expression Regulation by Artificial Control of Transcription Factors

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2003 - 2004

IZUMI Shin-ichi, KOJI Takehiko, TAKANO Kunio, HISHIKAWA Yoshitaka
Effect of iron as an environmental poisonous compound upon the precocious development of human hepatocellular carcinoma in Myanmar

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2001 - 2003

KOJI Takehiko, IZUMI Shinichi, EJIMA Kuniaki, HISAKAWA Yoshitaka, ABE Kuniko, OKADA Shigeru
マウス生殖細胞死への環境毒性物質の影響とその分子機能の解析

内分泌攪乱化学物質等の作用メカニズムの解明等基礎的研究, 環境省, Apr, 2000 - Mar, 2002

小路武彦
Variety and uniformity in the mechanisms underlying the induction of germ cell apoptosis

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2000 - 2002

TAKEHIKO Koji, IZUMI Shinichi, SHIN Masashi, HISHIKAWA Yoshitaka
糖尿病の奇形発生におけるアポトーシスの誘導機構と分子メカニズムの解明

科学研究費助成事業, 基盤研究(C), 日本学術振興会, 2000 - 2001

赤澤昭一, 近藤宇史, 小路武彦
Adhesion-dependent growth of ATL cells ; significance of signaling pathway through adhesion molecules

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2000 - 2001

NAGAI Kazuhiro, TOMONAGA Masao, KOJI Takehiko, JINNAI Itsuroh
Molecular Histo-cytochemical Analysis of Gene Transcription Factors Reflecting in the Regulation of Functional Differentiation of the Cell

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 1999 - 2001

IZUMI Shin-ichi, SHIN Masashi, KOJI Takehiko
The study of the pathophysiology of endometriosis and the relation between endometriosis and infertility

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 1998 - 2001

FUJISHITA Akira, KOJI Takehiko, ISHIMARU Tadayuki

Industrial Property Rights

特願2000-115167 ヒトKGFに対する抗体

小路武彦, 中村充
特開2001-302699 ヒトKGFRに対する抗体

小路武彦, 中村充
特許1956782 核酸の検出方法及びこれに用いるプローブ

中根一穂, 丹野眞志, 小路武彦, 守内哲也

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