堀内正久 (Masahisa Horiuchi) - マイポータル

基本情報

所属: 鹿児島大学大学院医歯学総合研究科人間環境学講座環境医学研究分野教授

学位: 博士（医学）(鹿児島大学)

J-GLOBAL ID: 200901075936155306
researchmap会員ID: 1000164843

外部リンク: http://www.kufm.kagoshima-u.ac.jp/~eisei001/index.html

研究キーワード

研究分野

経歴

2013年1月 - 現在

鹿児島大学, 医歯学域医学系衛生学・健康増進医学, 教授
1998年 - 2000年

ドイツマックスプランク脳研究施設神経化学部門ポスドク
1998年 - 2000年

Max-Planck・Institute Brain Research Neurochemistry, Research fellow
1994年 - 1996年

Kagoshima University, Research Assistant
1996年

~ 鹿児島大学医学部講師
1994年 - 1995年

鹿児島大学医学部助手

学歴

委員歴

受賞

論文

Deteriorated glucose metabolism with a high-protein, low-carbohydrate diet in db mice, an animal model of type 2 diabetes, might be caused by insufficient insulin secretion

Emi Arimura, Wijang Pralampita Pulong, Ancah Caesarina Novi Marchianti, Miwa Nakakuma, Masaharu Abe, Miharu Ushikai, Masahisa Horiuchi

EUROPEAN JOURNAL OF NUTRITION 56(1) 237-246 2017年2月査読有り
Carnitine deficiency induces a short QT syndrome

Julien Roussel, Francois Labarthe, Jerome Thireau, Fabio Ferro, Charlotte Farah, Jerome Roy, Masahisa Horiuchi, Martine Tardieu, Bruno Lefort, Jean Francois Benoist …

HEART RHYTHM 13(1) 165-174 2016年1月査読有り
Mechanism for increased hepatic glycerol synthesis in the citrin/mitochondrial glycerol-3-phosphate dehydrogenase double-knockout mouse: Urine glycerol and glycerol 3-phosphate as potential diagnostic markers of human citrin deficiency.

Moriyama M, Fujimoto Y, Rikimaru S, Ushikai M, Kuroda E, Kawabe K, Takano K, Asakawa A, Inui A, Eto K …

Biochimica et biophysica acta 1852(9) 1787-1795 2015年9月査読有り
Angle between the common and internal carotid arteries detected by ultrasound is related to intima-media thickness among those with atherosclerotic disease

Satoshi Daitoku, Toshinori Yuasa, Hiroshi Tsunenari, Shigeho Maenohara, Kazuharu Mine, Yuichi Tamatsu, Kazuyuki Shimada, Chihaya Koriyama, Mitsuru Ohishi, Masahisa Horiuchi

ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE 20(3) 216-223 2015年5月査読有り
[Experimental Approach to Analysis of the Relationship between Food Environments and Lifestyle-Related Diseases, Including Cardiac Hypertrophy, Fatty Liver, and Fatigue Symptoms].

Horiuchi M, Nakakuma M, Arimura E, Ushikai M, Yoshida G

Nihon eiseigaku zasshi. Japanese journal of hygiene 70(2) 110-114 2015年査読有り
Voluntary exercise under a food restriction condition decreases blood branched-chain amino acid levels, in addition to improvement of glucose and lipid metabolism, in db mice, animal model of type 2 diabetes

Ancah Caesarina Novi Marchianti, Emi Arimura, Miharu Ushikai, Masahisa Horiuchi

ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE 19(5) 339-347 2014年9月査読有り
Effect of myeloperoxidase inhibition on gene expression profiles in HL-60 cells exposed to 1, 2, 4,-benzenetriol

Emiko Miyahara, Takuro Nishikawa, Toru Takeuchi, Kaori Yasuda, Yasuhiro Okamoto, Yoshifumi Kawano, Masahisa Horiuchi

TOXICOLOGY 317 50-57 2014年3月査読有り
Investigation of necessity of sodium cholate and minimal required amount of cholesterol for dietary induction of atherosclerosis in microminipigs.

Akioka K, Kawaguchi H, Kitajima S, Miura N, Noguchi M, Horiuchi M, Miyoshi N, Tanimoto A

In vivo (Athens, Greece) 28(1) 81-90 2014年1月査読有り
Effects of aging on the plasma levels of nesfatin-1 and adiponectin.

Li JB, Nishida M, Kaimoto K, Asakawa A, Chaolu H, Cheng KC, Li YX, Terashi M, Koyama KI, Amitani H …

Biomedical reports 2(1) 152-156 2014年1月査読有り
Ornithine ingestion improved sleep disturbances but was not associated with correction of blood tryptophan ratio in Japanese Antarctica expedition members during summer

Masahisa Horiuchi, Hirohiko Kanesada, Takahiro Miyata, Kentaro Watanabe, Akihito Nishimura, Takashi Kokubo, Takayoshi Kirisako

NUTRITION RESEARCH 33(7) 557-564 2013年7月査読有り

MISC

カルニチン欠乏・脂質代謝と疲労

Molecular Medicine（中山書店） 1235-1242 2004年
分子栄養学（分担）

KENPAKUSYA 2003年
Improved matrix-assisted laser desorption/ionization time-of-flight mass spectrometric method for identification of amino acid o-glycosides in patients with a-N-acetylgalactosaminidase

Clin Chem 10, 1798-1799 2002年
Novel mRNA molecules are induced in hypertrophied ventricles of carnitine-deficient mice and belong to a family of up-regulated gene in cells overexpressing c-erbB2

Biochem Biophys Acta 1577, 437-444 2002年
Improved matrix-assisted laser desorption/ionization time-of-flight mass spectrometric method for identification of amino acid o-glycosides in patients with a-N-acetylgalactosaminidase deficiency

Clin Chem 10, 1798-1799 2002年
Novel mRNA molecules are induced in hypertrophied ventricles of carnitine-deficient mice and belong to a family of up-regulated gene in cells overexpressing c-erbB-2

Biochim Biophys Acta 1577, 437-444 2002年
Surface-localized glycine transporters 1 and 2 function as monomeric proteins in Xenopus oocytes

Proc Natl Acad Sci USA 98, 1448-1453 2001年
Surface-localized glycine transporters 1 and 2 function as monomeric proteins in Xenopus Oocytes

Proc Natl Acad Sci USA 98,1448-1453 2001年
Ulip6, a novel unc-33 and dihydropyrimidinase related protein highly expressed in developing rat brain

M Horiuchi, O El Far, H Betz

FEBS LETTERS 480(2-3) 283-286 2000年9月
Ulip6, a novel unc-33 and dihydropyrimidinase related protein highly expressed in developing rat brain

FEBS Lett 480, 283-286 2000年
The signaling pathway of cardiotrophin-1 is not activated in hypertrophied ventricles of carnitine-deficient juvenile visceral steatosis (JVS) mice

in vivo 14, 401-406 2000年
Cardiomegaly in the juvenile visceral steatosis (JVS) mouse is reduced with acute elevation of heart short-chain acyl-carnitine level after l-carnitine injection

FEBS Lett 443, 261-266 1999年
Catecholamine metabolism inhibitors and receptor blockades only partially suppress cardiac hypertrophy of juvenile visceral steatosis mice with systemic carnitine deficiency

Life Sci 64, 1137-1144 1999年
Pyruvate dehydrogenase kinase 4 mRNA is increased in the hypertrophied ventricles of carnitine -deficient juvenile visceral steatosis (JVS) mice

BioFactors 10, 301-309 1999年
「病気の成り立ちとからだＩ」症候別病態生理編

医歯薬出版 13-19, 175-213 1998年
Secondary abnormality of carnitine biosynthesis results from carnitine reabsorptional system defect in juvenile visceral steatosis mice

Masahisa Horiuchi, Keiko Kobayashi, Naomasa Asaka, Takeyori Saheki

Biochimica et Biophysica Acta - Molecular Basis of Disease 1362(2-3) 263-268 1997年12月31日
The effect of carnitine on ketogenesis in perfused livers from juvenile visceral steatosis mice with systemic carnitine deficiency

Pediatr Res 42, 108-113 1997年
Pancreatic secretory trypsin inhibitor as adiagnostic marker for adult-onset type II citrullinemia

Hepatology 25, 1160-1165 1997年
Altered expression of atrial natriuretic peptide and contractile protein genes in hypertrophied ventricle of JVS mice with systemic carnitine deficiency

J Mol Cell Cardiol 29, 571-578 1997年
Altered expression of atrial natriuretic peptide and contractile protein genes in hypertrophied ventricle of JVS mice with systemic carnitine deficiency

J Mol Cell Cardiol 29, 571-578 1997年

もっとみる

書籍等出版物

医科アンモニア学：アンモニア濃度測定法

メディカルレビュー社 1995年

所属学協会

Works(作品等)

疲労および疲労感の分子・神経メカニスム

1999年 - 2004年
Mechanism of fatigue and feeding on fatigue

1999年 - 2004年
平成１４年度日本ビタミン学会市民公開講座（鹿児島）「ビタミン：研究の歴史から新しい機能まで」事務担当

2002年

共同研究・競争的資金等の研究課題

運動と栄養

2007年
カルニチン欠乏の病態解析

1990年
Study on pathophysiology of carnitine deficiency

1990年
心肥大の発症メカニズム
Research on Cardiac hypertrophy