Nakajima Toshihiro

J-GLOBAL         Last updated: Jun 14, 2019 at 17:08
 
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Name
Nakajima Toshihiro
Affiliation
St.Marianna University School of Medicine
Section
Institute of Medical Science Incurable Disease Research Center
Job title
Others,Professor
Degree
-

Research Areas

 

Education

 
 
 - 
1989
Faculty of Medicine, Kagoshima University
 

Published Papers

 
Abatacept in combination with methotrexate in Japanese biologic-naïve patients with active rheumatoidarthritis: a randomised placebocontrolledphase IV study
Nakajima Toshihiro
RMD Open      Dec 2018   [Refereed]
Identification of the inhibitory activity of E3 ligase Syvn1 in walnut extract
Nakajima Toshihiro
Mol. Med. Rep      2018   [Refereed]
An E3 Ubiquitin Ligase, Synoviolin, Is Involved in the Degradation of Homocysteine-Inducible Endoplasmic Reticulum Protein.
Nakajima Toshihiro
Biol. Pharm. Bull   46(6) 915-919   2018   [Refereed]
The NRF2-PGC-1β pathway activates kynurenine aminotransferase 4 via attenuation of an E3 ubiquitin ligase, Synoviolin, in a cecal ligation/perforation -induced septic mouse model.
NAKAJIMA Toshihiro
Molecular Medicine Reports.      2018   [Refereed]
NAKAJIMA Toshihiro
Prog Neuropsychopharmacol Biol Psychiatry.   75 120-127   2017   [Refereed]
nhibitory effects of ubiquitination of synoviolin by PADI4.
NAKAJIMA Toshihiro
Mol. Med. Rep.      2017   [Refereed]
NAKAJIMA Toshihiro
J. Hard Tissue Biol.   25(4) 377-382   2016   [Refereed]
Adverse effects of human papolloma virus vaccination on central nervous system:Neuro-endocrinological disorders of hypothalamo-pituitary axis.
NAKAJIMA Toshihiro
The Autonomic Nervous System   53(1) 49-64   2016   [Refereed]
NAKAJIMA Toshihiro
Biochem Biophys Res Commun.   473(4) 1276-1280   2016   [Refereed]

Misc

 
Yagishita N, Yamasaki S, Nishioka K, Nakajima T.
Nature Clin Prac Rheum      2007
The roles of Synoviolin in crosstalk between endoplasmic reticulum stress-induced apoptosis and p53 pathway.
Yamasaki S, Yagishita N, Nishioka K, Nakajima T.
Cell Cycle   6(11) 1-5   2007
Wu W, Nishikawa H, Hayami R, Sato K, Honda A, Aratani S, Nakajima T, Fukuda M, Ohta T.
Cancer Res   67(3) 951-58   2007
Yamasaki S, Yagishita N, Sasaki T, Nakazawa M, Kato Y, Yamadera T, Bae E, Toriyama S, Ikeda R, Zhang L, Fujitani K, Yoo E, Tsuchimochi K, Ohta T, Araya N, Fujita H, Aratani S, Eguchi K, Komiya S, Maruyama I, Higashi N, Sato M, Senoo H, Ochi T, Yokoyama S, Amano T, Kim J, Gay S, Fukamizu A, Nishioka K, Tanaka K, Nakajima T.
EMBO J   26(1) 113-122   2007

Books etc

 
Rheumatic manifestation of human leukemia virus infection
Rheumatology clinics North America(W. B. Sounders)   1993   

Conference Activities & Talks

 
What Rheumatoid synovial cells tell us: apoptosis
Nakajima Toshihiro
APLAR’S EXTENSIVE COURSE ON RHEUMATOLOGY   28 Jun 2018   
Development of novel regulatory methods of mitochondrial functions
Nakajima Toshihiro
The 16th International Symposium on Advanced Technology (ISAT-16)   Nov 2017   
Synoviolin as a novel factor for Rhematoid Arthritis, chronic inflammation and metabolic disorders
Nakajima Toshihiro
18th Myanmar Internal Medicine Conference 2017(in conjunction with 4th AFIM congress and 4th ACP Southeast Asian Chapter Meeting)   Oct 2017   
A study on our novel murine model of Humanpapillomavirus-associated Neuroimmunopathic Syndrome (HANS)
Nakajima Toshihiro
Sep 2017   
E3 Ubiquitin ligase synoviolin inhibitors has effects on obesity
Nakajima Toshihiro
International Conference on Obesity and Chronic Diseases (ICOCD-2016)   Jul 2016   

Research Grants & Projects

 
Molecular epigenetical analyses of risk factors of rheumatic fever and rheumatic heart disorders in Kyrgyz Republic.
Project Year: 2016 - 2019    Investigator(s): NAKAJIMA Toshihiro
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(A))
Project Year: 2008 - 2011    Investigator(s): Toshihiro NAKAJIMA
(抄録なし)
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2004 - 2006    Investigator(s): Toshihiro NAKAJIMA
Synoviolin is an E3 ubiquitin ligase and is implicated in endoplasmic reticulum-associated degradation. In mammals, Synoviolin plays crucial roles in various physiological and pathological processes, including embryogenesis and the pathogenesis of...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2000 - 2002    Investigator(s): Toshihiro NAKAJIMA
In the eukaryotic gene expression, recruitment of the basal transcriptional machinery including RNA polymerase (Pol) II is a principle mechanism for transcriptional activation. A specific transcriptional factor interacts with components of this ma...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2000 - 2002    Investigator(s): Toshihiro NAKAJIMA
To assess the implication of transcriptional coactivator in rheumatoid synoviocytes activation, we attempted the following two approaches. One is evaluation of nuclear acetylation, one of the critical roles as coactivator function of CREB binding ...