2006年2月
The role of leptin in the development of the cerebral cortex in mouse embryos
ENDOCRINOLOGY
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- 巻
- 147
- 号
- 2
- 開始ページ
- 647
- 終了ページ
- 658
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1210/en.2005-0791
- 出版者・発行元
- ENDOCRINE SOC
Leptin is detected in the sera, and leptin receptors are expressed in the cerebrum of mouse embryos, suggesting that leptin plays a role in cerebral development. Compared with the wild type, leptin-deficient (ob/ob) mice had fewer cells at embryonic day (E) 16 and E18 and had fewer 5-bromo-2'-deoxyuridine(+) cells at E14 and E16 in the neuroepithelium. Intracerebroventricular leptin injection in E14 ob/ob embryos increased the number of neuroepithelium cells at E16. In cultured neurosphere cells, leptin treatment increased Hes1 mRNA expression and maintained neural progenitors. Astrocyte differentiation was induced by low-dose (0.1 mu g/ml) but not high-dose (1 mu g/ ml) leptin. High-dose leptin decreased Id mRNA and increased Ngn1 mRNA in neurosphere cells. The neuropeptide Y mRNA level in the cortical plate was lower in ob/ob than the wild type at E16 and E18. These results suggest that leptin maintains neural progenitors and is related to glial and neuronal development in embryos.
- リンク情報
- ID情報
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- DOI : 10.1210/en.2005-0791
- ISSN : 0013-7227
- Web of Science ID : WOS:000234831200002