MISC

1998年2月

Time-dependent and regional expression of GABA transporter mRNAs following amygdala-kindled seizures in rats

MOLECULAR BRAIN RESEARCH
  • T Hirao
  • ,
  • K Morimoto
  • ,
  • Y Yamamoto
  • ,
  • T Watanabe
  • ,
  • H Sato
  • ,
  • K Sato
  • ,
  • S Sato
  • ,
  • N Yamada
  • ,
  • K Tanaka
  • ,
  • H Suwaki

54
1
開始ページ
49
終了ページ
55
記述言語
英語
掲載種別
DOI
10.1016/S0169-328X(97)00323-9
出版者・発行元
ELSEVIER SCIENCE BV

To investigate the role played by GABA transporters in epileptic seizures, we examined time-dependent and regional changes in expression of GAT-1 and GAT-3 GABA transporter mRNA in amygdala-kindled rat brain using an in situ hybridization method. GAT-1 mRNA was significantly increased bilaterally in the hippocampal dentate gyrus (111-116%) at 1 h after kindled generalized seizures. GAT-1 mRNA was also significantly increased bilaterally in the hippocampal subfields (CA1-4 and dentate gyrus [110-117%]) at 4 h after kindled seizures. There were no significant changes in GAT-1 mRNA level in the amygdalar nuclei, pyriform cortex or cerebral cortex either ipsilaterally or contralaterally at any time after kindled seizures. In contrast, GAT-3 mRNA was significantly increased bilaterally in the amygdalar nuclei and in the contralateral pyriform cortex and cerebral cortex 1 h after seizures. Since all these changes returned to control levels by 8 or 24 h after kindled seizures, the increases in GABA transporter mRNA appeared to be transient responses to seizure activity. These findings indicate that GAT-1 subtype transporter is specifically involved in seizure activity in the hippocampus, while GAT-3 subtype transporter is mainly involved in seizure activity in the amygdalar nuclei and pyriform cortex following amygdala-kindled generalized seizures. (C) 1998 Elsevier Science B.V.

Web of Science ® 被引用回数 : 34

リンク情報
DOI
https://doi.org/10.1016/S0169-328X(97)00323-9
CiNii Articles
http://ci.nii.ac.jp/naid/10021189289
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/9526043
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000072593600005&DestApp=WOS_CPL

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