小島隆 (Kojima Takashi) - マイポータル - researchmap

基本情報

所属: 札幌医科大学医学部医学科病理学第二講座医学部医学科基礎医学部門講座病理学第二講座助教授

学位: 博士（医学）

J-GLOBAL ID: 200901007605888928
researchmap会員ID: 1000165781

研究キーワード

3

学歴

2

- 1985年

岐阜大学
- 1985年

岐阜大学

受賞

3

MISC

47

p38 MAP-kinase regulates function of gap and tight junctions during regeneration of rat hepatocytes

T Yamamoto, T Kojima, M Murata, K Takano, M Go, N Hatakeyama, H Chiba, N Sawada

JOURNAL OF HEPATOLOGY 42(5) 707-718 2005年5月
Glyceraldehyde-derived advanced glycation end-products preferentially induce VEGF expression and reduce GDNF expression in human astrocytes

H Miyajima, M Osanai, H Chiba, N Nishikiori, T Kojima, K Ohtsuka, N Sawada

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 330(2) 361-366 2005年5月
HLA-DR- and CD11c-positive Dendritic Cells Penetrate beyond Well-developed Epithelial Tight Junctions in Human Nasal Mucosa of Allergic Rhinitis.

J Histochem Cytochem 53 611-9 2005年
Activation of p21 (CIP1/WAF1) gene expression and inhibition of cell proliferation by overexpression of hepatocyte nuclear factor-4 alpha

H Chiba, T Itoh, S Satohisa, N Sakai, H Noguchi, M Osanai, T Kojima, N Sawada

EXPERIMENTAL CELL RESEARCH 302(1) 11-21 2005年1月
Oncogenic Raf-1 regulates epithelial to mesenchymal transition via distinct signal transduction pathways in an immortalized mouse hepatic cell line

MD Lan, T Kojima, M Osanai, H Chiba, N Sawada

CARCINOGENESIS 25(12) 2385-2395 2004年12月
IL-1 beta regulates expression of Cx32, occludin, and claudin-2 of rat hepatocytes via distinct signal transduction pathways

T Yamamoto, T Kojima, M Murata, K Takano, M Go, H Chiba, N Sawada

EXPERIMENTAL CELL RESEARCH 299(2) 427-441 2004年10月
Expression profiles and functional implications of p53-like transcription factors in thymic epithelial cell subtypes

T Kikuchi, S Ichimiya, T Kojima, L Crisa, S Koshiba, A Tonooka, N Kondo, PT van der Saag, S Yokoyama, N Sato

INTERNATIONAL IMMUNOLOGY 16(6) 831-841 2004年6月
Thr(203) of claudin-1, a putative phosphorylation site for MAP kinase, is required to promote the barrier function of tight junctions

M Fujibe, H Chiba, T Kojima, T Soma, T Wada, T Yamashita, N Sawada

EXPERIMENTAL CELL RESEARCH 295(1) 36-47 2004年4月
Tight junction protein MAGI-1 is up-regulated by transfection with connexin 32 in an immortalized mouse hepatic cell line: cDNA microarray analysis.

Cell Tissue Res 19 0-0 2004年
Thr(207) of claudin-5 is involved in size-selective loosening of the endothelial barrier by cyclic AMP.

Exp Cell Res 15 201-12 2004年
Expression and function of tight junctions in the crypt epithelium of human palatine tonsils.

J Histochem Cytochem 12 1627-38 2004年
Inhibition of MAP kinase activity moderates changes in expression and function of Cx32 but not claudin-1 during DNA synthesis in primary cultures of rat hepatocytes.

Med Electron Microsc 37 101-13 2004年
Cyclic AMP induces phosphorylation of claudin-5 immunoprecipitates and expression of claudin-5 gene in blood-brain-barrier endothelial cells via protein kinase A-dependent and -independent pathways

T Ishizaki, H Chiba, T Kojima, M Fujibe, T Soma, H Miyajima, K Nagasawa, Wada, I, N Sawada

EXPERIMENTAL CELL RESEARCH 290(2) 275-288 2003年11月
Tight junctions and human diseases

Norimasa Sawada, Masaki Murata, Keisuke Kikuchi, Makoto Osanai, Hirotoshi Tobioka, Takashi Kojima, Hideki Chiba

Medical Electron Microscopy 36(3) 147-156 2003年9月
Regulation of the blood-biliary barrier: Interaction between gap and tight junctions in hepatocytes

Takashi Kojima, Toshinobu Yamamoto, Masaki Murata, Hideki Chiba, Yasuo Kokai, Norimasa Sawada

Medical Electron Microscopy 36(3) 157-164 2003年9月
Role of the p38 MAP-kinase signaling pathway for Cx32 and claudin-1 in the rat liver

T Kojima, T Yamamoto, M Murata, M Lan, KI Takano, M Go, S Ichimiya, H Chiba, N Sawada

CELL COMMUNICATION AND ADHESION 10(4-6) 437-443 2003年7月
Hepatocyte nuclear factor (HNF)-4 alpha triggers formation of functional tight junctions and establishment of polarized epithelial morphology in F9 embryonal carcinoma cells

H Chiba, T Gotoh, T Kojima, S Satohisa, K Kikuchi, M Osanai, N Sawada

EXPERIMENTAL CELL RESEARCH 286(2) 288-297 2003年6月
Epigenetic inactivation of CHFR and sensitivity to microtubule inhibitors in gastric cancer.

Cancer Res 63 8606-13 2003年
Hepatocyte nuclear factor (HNF)-4 alpha induces expression of endothelial Fas ligand (FasL) to prevent cancer cell transmigration: A novel defense mechanism of endothelium against cancer metastasis

M Osanai, H Chiba, T Kojima, M Fujibe, K Kuwahara, H Kimura, M Satoh, N Sawada

JAPANESE JOURNAL OF CANCER RESEARCH 93(5) 532-541 2002年5月
Cx32 formation and/or Cx32-mediated intercellular communication induces expression and function of tight junctions in hepatocytic cell line

T Kojima, DC Spray, Y Kokai, H Chiba, Y Mochizuki, N Sawada

EXPERIMENTAL CELL RESEARCH 276(1) 40-51 2002年5月

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所属学協会

8

共同研究・競争的資金等の研究課題

2