論文

査読有り
2013年2月

Combined effect of mitochondrial DNA 5178 C/A polymorphism and alcohol consumption on estimated glomerular filtration rate in male Japanese health check-up examinees: a cross-sectional study

BMC NEPHROLOGY
  • Akatsuki Kokaze
  • Mamoru Ishikawa
  • Naomi Matsunaga
  • Kanae Karita
  • Masao Yoshida
  • Naoki Shimada
  • Tadahiro Ohtsu
  • Takako Shirasawa
  • Hirotaka Ochiai
  • Hiromi Hoshino
  • Yutaka Takashima
  • 全て表示

14
開始ページ
35
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1186/1471-2369-14-35
出版者・発行元
BIOMED CENTRAL LTD

Background: Prevention of chronic kidney disease (CKD) is a major public health issue. Although several studies have been performed on the association between alcohol consumption and CKD or renal function, it remains controversial. Numerous genetic polymorphisms have been reported to be associated with CKD and kidney function. Mitochondrial DNA cytosine/adenine (Mt5178 C/A) polymorphism is associated with longevity in Japanese. This polymorphism modifies the effects of alcohol consumption on blood pressure, risk of hypertension, serum triglyceride levels, risk of hyper-LDL cholesterolemia and serum uric acid levels. The objective of this study was to investigate whether Mt5178 C/A polymorphism modifies the effects of alcohol consumption on renal function in male Japanese health check-up examinees.
Methods: A total of 394 male subjects aged 29-76 years were selected from among individuals visiting the hospital for regular medical check-ups. After Mt5178 C/A genotyping, a cross-sectional study assessing the combined effects of Mt5178 C/A polymorphism and habitual drinking on the risk of mildly decreased estimated glomerular filtration rate (eGFR) (<90 ml/min/1.73 m(2)) was conducted.
Results: For Mt5178A genotypic men, habitual drinking may increase eGFR (P for trend = 0.003) or reduce the risk of mildly decreased eGFR (P for trend = 0.003). Daily drinkers had a significantly higher eGFR than non-drinkers (P = 0.005). The crude odds ratio for decreased eGFR was significantly lower in daily drinkers than in non-drinkers (odds ratio = 0.092, 95% confidence interval: 0.012-0.727, P = 0.024). On the other hand, for Mt5178C genotypic men, habitual drinking does not appear to affect eGFR.
Conclusion: The present results suggest a joint effect of Mt5178 C/A polymorphism and alcohol consumption on eGFR and the risk of mildly decreased eGFR in male Japanese subjects.

リンク情報
DOI
https://doi.org/10.1186/1471-2369-14-35
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000315121600001&DestApp=WOS_CPL
ID情報
  • DOI : 10.1186/1471-2369-14-35
  • ISSN : 1471-2369
  • eISSN : 1471-2369
  • Web of Science ID : WOS:000315121600001

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