2003年4月
Gaf-1b is an alternative splice variant of Gaf-1/Rip11
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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- 巻
- 303
- 号
- 4
- 開始ページ
- 1042
- 終了ページ
- 1046
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/S0006-291X(03)00486-8
- 出版者・発行元
- ACADEMIC PRESS INC ELSEVIER SCIENCE
Gaf-1/Rip11 encoded by the clone KIAA0857 participates in endosomal recycling through the interaction with both gamma-SNAP, a member of the soluble NSF attachment protein family, and a small GTPase, Rab11. Gaf-1/Rip11 and other Rab11-interacting proteins constitute a novel protein family that is involved in the endocytic pathways. Here we report the presence of an alternative splice variant of Gaf-1/Rip11 named Gaf-1b. Gaf-gammab also interacts with gamma-SNAP and is expressed ubiquitously in tissues except for liver. Subcellular fractionation analysis revealed that Gaf-1b, as well as Gaf-1/Rip11, is mainly present in the microsomal fraction. Overexpression of Gaf-1b, like that of Gaf-1/Rip11, affected the morphology of recycling endosomes. These results suggest that Gaf-1b has a similar function to Gaf-1/Rip11. (C) 2003 Elsevier Science (USA). All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/S0006-291X(03)00486-8
- ISSN : 0006-291X
- Web of Science ID : WOS:000182524600010