MORI Hiroyuki

J-GLOBAL         Last updated: Jun 24, 2019 at 19:47
 
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Name
MORI Hiroyuki
Affiliation
Kyoto University
Section
Institute for Virus Research
Degree
Doctor of Science(Osaka University)
ORCID ID
0000-0002-0429-1269

Research Interests

 
 

Research Areas

 
 

Academic & Professional Experience

 
1992
 - 
1993
Osaka University, instructor
 
1993
 - 
1996
Tokyo University of Pomnacy and Life Science, instructor
 

Education

 
 
 - 
1990
Graduate School, Division of Natural Science, Osaka University
 
 
 - 
1988
Faculty of Science, Osaka University
 

Published Papers

 
A photo-cross-linking approach to monitor protein dynamics in living cells.
Miyazaki, R., Akiyama, Y. & Mori, H.
BBA-General subjects      2019   [Refereed]
Monitoring substrate enables real-time regulation of a protein localization pathway
Ito, K.*, Mori, H. & Chiba, S.
FEMS Mibrobiology Letters   365(11)    Jun 2018   [Refereed]
Identification and characterization of arrest motif in VemP by systematic mutational analysis.
Mori, H.*, Sakashita, S., Ito, J., Ishii, E. and Akiyama, Y.
J. Biol. Chem.   293(8) 2915-2926   Feb 2018   [Refereed]
A new photo-cross-linking approach for analysis of protein dynamics in vivo.
Miyazaki, R., Myogo, N., Mori, H. and Akiyama, Y.*
J. Biol. Chem.   293 677-686   Jan 2018   [Refereed]
Heat shock transcription factor 32 defective in membrane transport can be suppressed by transposon insertion into the genes for a restriction enzyme subunit or a putative autotransporter in E. coli.
Yura, T.*, Miyazaki, R.#, Fujiwara, K. #, Ito, K., Chiba, S., Mori, H. and Akiyama, Y.
Genes & Genetic Systems   93 229-235   2018   [Refereed]
BepA mediates productive transfer of substrate proteins to the β-barrel assembly machinery (BAM) complex.
Daimon, Y., Masui, C., Tanaka, Y., Shiota, T., Suzuki, T., Miyazaki, R., Sakurada, H., Lithgow, T., Dohmae, N., Mori, H., Tsukazaki, T.*, Narita, S.* and Akiyama, Y*
Mol. Microbiol.   106 760-776   2017   [Refereed]
Furukawa, A., Yoshikaie, K., Mori, T., Mori, H., Morimoto, Y. V., Sugano, Y., Iwaki, S., Minamino, T., Sugita, Y., Tanaka, Y. and Tsukazaki, T.
Cell Reports   19 895-901   2017   [Refereed]
Miyazaki, R., Yura, T., Suzuki, T. Dohmae, N., Mori, H. and Akiyama, Y.*
Scientfic reports   6    Apr 2016   [Refereed]
K. Akiyama, S. Mizuno, Y. Hizukuri, H. Mori, T. Nogi, Y. Akiyama
eLIFE   4(OCTOBER2015)    Oct 2015   [Refereed]
E Ishii, S Chiba, N Hashimoto, S Kojima, M Homma, K Ito, Y Akiyama, H. Mori
Proceedings of the National Academy of Sciences   112(40) E5513-E5522   Sep 2015   [Refereed]
Kumazaki, K., Kishimoto, T., Furukawa, A., Mori, H., Tanaka, Y., Dohmae, N., Ishitani, R., Tsukazaki, T., and Nureki, O.
Scientific Reports   4 7299   Dec 2014   [Refereed]
Kumazaki, K. *, Chiba, S. *, Takemoto, M., Furukawa, A., Nishiyama, K., Sugano Y., Mori, T., Dohmae, N., Hirata, K., Nakada-Nakura, Y., Maturana, A., Tanaka, Y., Mori, H., Sugita, Y., Arisaka, F., Ito, K., Ishitani, R., Tsukazaki, T. and Nureki O.
Nature   509(7501) 516-520   May 2014   [Refereed]
K. Mio; T. Tsukazaki; H. Mori; M. Kawata; T. Moriya; Y. Sasaki; R. Ishitani; K. Ito; O. Nureki; C. Sato
Journal of Structural and Functional Genomics   1-9   2014   [Refereed]
A. Saito; Y. Hizukuri; E.-I. Matsuo; S. Chiba; H. Mori; O. Nishimura; K. Ito; Y. Akiyama
Proceedings of the National Academy of Sciences of the United States of America   108(33) 13740-13745   Aug 2011   [Refereed]
T. Tsukazaki; H. Mori; Y. Echizen; R. Ishitani; S. Fukai; T. Tanaka; A. Perederina; D.G. Vassylyev; T. Kohno; A.D. Maturana; K. Ito; O. Nureki
Nature   474(7350) 235-238   May 2011   [Refereed]
The Sec protein secretion system ・ pp. 3-22, in Bacterial Secreted Proteins
Ito K. and Mori H.
Ed. K. Wooldridge, Caister Academic Press, Norfolk, UK, 2009      2009   [Refereed]
T. Tsukazaki; H. Mori; S. Fukai; R. Ishitani; T. Mori; N. Dohmae; A. Perederina; Y. Sugita; D.G. Vassylyev; K. Ito; O. Nureki
Nature   455(7215) 988-991   Oct 2008   [Refereed]
D.G. Vassylyev; H. Mori; M.N. Vassylyeva; T. Tsukazaki; Y. Kimura; T.H. Tahirov; K. Ito
Journal of Molecular Biology   364(3) 248-258   Dec 2006   [Refereed]
H. Mori; K. Ito
Proceedings of the National Academy of Sciences of the United States of America   103(44) 16159-16164   Oct 2006   [Refereed]
M.N. Vassylyeva; H. Mori; T. Tsukazaki; S. Yokoyama; T.H. Tahirov; K. Ito; D.G. Vassylyev
Acta Crystallographica Section F: Structural Biology and Crystallization Communications   62(Pt 9) 909-912   Sep 2006   [Refereed]
T. Tsukazaki; H. Mori; S. Fukai; T. Numata; A. Perederina; H. Adachi; H. Matsumura; K. Takano; S. Murakami; T. Inoue; Y. Mori; T. Sasaki; D.G. Vassylyev; O. Nureki; K. Ito
Acta Crystallographica Section F: Structural Biology and Crystallization Communications   62(Pt 4) 376-380   Apr 2006   [Refereed]
H. Mori; K. Ito
Journal of Biological Chemistry   281(47) 36249-36256   Nov 2006   [Refereed]
H. Nakatogawa; A. Murakami; H. Mori; K. Ito
Genes and Development   19(4) 436-444   Feb 2005   [Refereed]
H. Mori; N. Shimokawa; Y. Satoh; K. Ito
Journal of Bacteriology   186(12) 3960-3969   Jun 2004   [Refereed]
F. Cairrão; A. Cruz; H. Mori; C.M. Arraiano
Molecular Microbiology   50(4) 1349-1360   Nov 2003   [Refereed]
Y. Satoh; H. Mori; K. Ito
Biochemistry   42(24) 7442-7447   Jun 2003   [Refereed]
Y. Satoh; G. Matsumoto; H. Mori; K. Ito
Biochemistry   42(24) 7434-7441   Jun 2003   [Refereed]
N. Shimokawa; H. Mori; K. Ito
Molecular Genetics and Genomics   269(2) 180-187   May 2003   [Refereed]
H. Mori; T. Tsukazaki; R. Masui; S. Kuramitsu; S. Yokoyama; A.E. Johnson; Y. Kimura; Y. Akiyama; K. Ito
Journal of Biological Chemistry   278(16) 14257-14264   Apr 2003   [Refereed]
H. Mori; Y. Akiyama; K. Ito
Journal of Bacteriology   185(3) 948-956   Feb 2003   [Refereed]
E. Matsuo; H. Mori; K. Ito
Molecular Genetics and Genomics   268(6) 808-815   2003   [Refereed]
K. Chiba; H. Mori; K. Ito
Journal of Bacteriology   184(8) 2243-2250   Apr 2002   [Refereed]
H. Mori; Y. Shimizu; K. Ito
Journal of Biological Chemistry   277(50) 48550-48557   Dec 2002   [Refereed]
H. Mori; K. Ito
Trends in Microbiology   9(10) 494-500   Oct 2001   [Refereed]
H. Mori; K. Ito
Proceedings of the National Academy of Sciences of the United States of America   98(9) 5128-5133   Apr 2001   [Refereed]
G. Matsumoto; H. Nakatogawa; H. Mori; K. Ito
Genes to Cells   5(12) 991-999   Dec 2000   [Refereed]
H. Nakatogawa; H. Mori; K. Ito
Journal of Biological Chemistry   275(43) 33209-33212   Oct 2000   [Refereed]
S. Chiba; Y. Akiyama; H. Mori; E.-I. Matsuo; K. Ito
EMBO Reports   1(1) 47-52   Jul 2000   [Refereed]
Characterization of a mutant form of SecA that alleviates a SecY defect at low temperature and shows a synthetic defect with secy alteration at high temperature
H. Nakatogawa; H. Mori; G. Matsumoto; K. Ito
Journal of Biochemistry   127(6) 1071-1079   Jun 2000   [Refereed]
G. Matsumoto; T. Homma; H. Mori; K. Ito
Journal of Bacteriology   182(12) 3377-3382   Jun 2000   [Refereed]
G. Matsumoto; H. Mori; K. Ito
Proceedings of the National Academy of Sciences of the United States of America   95(23) 13567-13572   Nov 1998   [Refereed]
Y. Akiyama; A. Kihara; H. Mori; T. Ogura; K. Ito
Journal of Biological Chemistry   273(35) 22326-22333   Aug 1998   [Refereed]
E.-I. Matsuo; H. Mori; T. Shimoike; K. Ito
Journal of Biological Chemistry   273(30) 18835-18840   Jul 1998   [Refereed]
Amino-terminal region of SecA is involved in the function of SecG for protein translocation into Escherichia coli membrane vesicles
H. Mori; H. Sugiyama; M. Yamanaka; K. Sato; M. Tagaya; S. Mizushima
Journal of Biochemistry   124(1) 122-129   Jul 1998   [Refereed]
K. Sato; H. Mori; M. Yoshida; M. Tagaya; S. Mizushima
Journal of Biological Chemistry   272(32) 20082-20087   Aug 1997   [Refereed]
H. Mori; M. Araki; C. Hikita; M. Tagaya; S. Mizushima
Biochimica et Biophysica Acta - Biomembranes   1326(1) 23-36   May 1997   [Refereed]
K. Sato; H. Mori; M. Yoshida; M. Tagaya; S. Mizushima
Journal of Biological Chemistry   272(9) 5880-5886   Feb 1997   [Refereed]
K. Sato; H. Mori; M. Yoshida; S. Mizushima
Journal of Biological Chemistry   271(29) 17439-17444   Jul 1996   [Refereed]
K. Uchida; H. Mori; S. Mizushima
Journal of Biological Chemistry   270(52) 30862-30868   Dec 1995   [Refereed]

Misc

 
Structure, function and regulation of bacterial Sec machinery.
Ito K., Tsukazaki T., Mori H., Nureki O.
International Union of Microbiological Societies 2011 Congress, Symposium "Bacterial Protein Transport", September 6-10, Sapporo, Japan 2011      2011   [Refereed]
Structural Analysis of Bacterial Sec Translocon machinery.
Tsukazaki T, Mori H, Ito K, Nureki O
Gordon Research Conferences on Protein Transport Across Cell Membranes, Galveston, U.S.A, March 7-12, 2010      2010   [Refereed]
A functionally important intramolecular interaction in SecA: involvement of hydrophobic amino acids in motif IV and anti-parallel beta sheet in translocase activation
Mori H, Tsukazaki T, Nureki 0, Ito K, Akiyama Y
The 3rd International Symposium on Protein Community, Nara, September 13-16, 2010      2010   [Refereed]
Crystal structure of SecDF, a Sec translocon-associated membrane protein.
Tsukazaki T, Mori H, Echizen Y, Ishitani R, Fukai S, Tanaka T, Perederina A, Vassylyev D G, Kohno H, Echizen Y, Ishitani R, Fukai S, Tanaka T, Perederina A, Vassylyev D G, Kohno T, Ito K, Nureki O
The 3rd International Symposium on Protein Community, Nara, September 13-16, 2010      2010   [Refereed]
SRP-dependent targeting of sigma 32 to the membrane: A critical step for the chaperone-mediated feedback control in bacterial heat shock response.
Yura T, Lim B, Gross C, Ito K, Mori H, Akiyama Y
The 3rd International Symposium on Protein Community, Nara, September 13-16, 2010      2010   [Refereed]
Crystal structure of T. thermophilus Sec translocon with an Fab fragment implies a translocation-initiating state of SecY.
Tsukazaki T., Mori H., Fukai S., Ishitani R., Mori T., Dohmae N., Perederina A., Sugita Y., Vassylyev D. G., Ito K., Nureki O.
シンポジウム 「タンパク機発現システム - シャペロンからトランスロケーターまで」 第 回日本分子生物学会年会、第 回日本生化学会大会 合同大会 神戸 2008 年12月9-12 日      2008   [Refereed]
Protein quality control devices in the Escherichia coli plasma membrane.
Ito K., Shimohata N., Nagamori S., Kaback H.R., Sakoh M., Chiba S., Mori H., Akiyama Y.
20th IUBMB International Congress of Biochemistry and Molecular Biology. Symposium Quality Control of Proteins and Proteolysis, Abstract p. 75, Jun 18-23,2006      2006   [Refereed]
Preparation of supported lipid membrane for analyses of membrane proteins on a quartz-crystal microbalance (QCM) .
Mitomo H., Ishizu Y., Furusawa H., Tsukazaki T., Mori H., Ito K., Okahata Y.
20th IUBMB International Congress of Biochemistry and Molecular Biology. Abstract p. 337, Jun 18-23, 2006      2006   [Refereed]
SecY alterations that impair membrane protein folding and generate a membrane stress.
Ito K., Nagamori S., Shimohata N., Mori H., Akiyama Y., Kaback H.R.
ASM-FEMS Conerence Protein Traffic in Prokaryotes. Abstract p. 14, May 6-10, 2006      2006   [Refereed]
Site-specific crosslinking studies of in vivo SecY-SecA interactions.
Mori H., Shimokawa N., Ito K.
ASM-FEMS Conerence Protein Traffic in Prokaryotes. Abstract p. 53, May 6-10, 2006      2006   [Refereed]
Stress response devices in the E. coli plasma membrane and their ability to sense abnormality of integral membrane proteins.
Ito K., Shimohata N., Mori H., Kanehara K., Akiyama Y.
IUMS 2005. XI International Congress of Bacteriology and Applied Microbiology. Symposium "Envelope Stress". Abstracts p. 214-215. July 23-28, San Francisco, California, USA, 2005      2005   [Refereed]
The long α-helix of SecA is important for the coupling of ATP hydrolysis \nwith protein translocation
Mori H., Ito K.
Gordon Research Conferences "Protein transport across cell membranes". June 15-17, New Hampshre, USA, 2005      2005   [Refereed]
Coordinated functions of SecA-SecYEG protein translocation system.
Ito K., Shimohata N., Nakatogawa H., Murakami A., Muto H., Akiyama Y., Tsukazaki T., Mori H.
International Symposium on Life of Proteins. Maturation, Translocation and Quality Control in the Cell. 10.30-11.3, Awajisima, Hyogo, Japan, 2005      2005   [Refereed]
Structural analysis of Thermus thermophilus protein translocation complexes.
Tsukazaki T., Mori H., Peredrerina A., Vassylyev D. G., Fukai S., Nureki O., Ito K.
International Symposium on Life of Proteins. Maturation, Translocation and Quality Control in the Cell. 10.30-11.3, Awajisima, Hyogo, Japan, 2005      2005   [Refereed]

Books etc

 
The Sec protein secretion system
Ito, K. and Mori, H.
Caister Academic Press, Norfolk, UK.   2009   

Conference Activities & Talks

 
Nascent chain-monitored remodeling of the Sec machinery for salinity adaptation of a marine bacterium, Vibrio alginolyticus. [Invited]
MORI Hiroyuki
Commemorative symposium for 33rd international prize for biology ‘Marine biology opens a frontier for the future’   5 Dec 2017   
Identification and characterization of a translation arrest motif in VemP by systematic mutational analysis. [Invited]
Mori, H., Sakashita, S., Ito, J., Ishii, E. and Akiyama, Y.
19 Sep 2017   
Structure and Physiological Function of SecDF That Enhances Protein Export. [Invited]
MORI Hiroyuki
International symposium ‘Harmonized supermolecular motility machinery and its diversity’   13 Sep 2017   
Nascent chain-monitored remodeling of the Sec machinery for salinity adaptation of marine bacteria. [Invited]
Mori, H., Ishii, E., Chiba, S., Sakashita, S., Ito, K. & Akiyama, Y.
NASCENT CHAIN BIOLOGY   1 Sep 2016   
Environmental adaptation of marine Vibrio by nascent chain-mediated remodeling of protein export machinery. [Invited]
MORI Hiroyuki
27 Jun 2016   
Nascent chain-monitored remodeling of the Sec machinery for salinity adaptation of marine bacteria. [Invited]
8. Mori, H., Ishii, E., Chiba, S., Hashimoto, N., Kojima, S., Homma, M., Ito, K. and Akiyama, Y.
BMB2015   3 Dec 2015   
Nascent chain-mediated regulation of a SecDF paralog optimizes sodium dependence of protein export for environmental adaptation of a marine-estuarine bacterium, Vibrio alginolyticus. [Invited]
Mori, H., Ishii E., Chiba, S., Hashimoto, N., Kojima, S., Homma, M., Ito, K. and Akiyama, Y.
Kyushu-U and Stanford-U Joint Research and Education Program, First Symposium: From Genes to Human Diseases, Fukuoka,   16 Mar 2015   
Structure and function of SecDF, a membrane integrated protein translocation enhancing factor
第86回日本細菌学会ワークショップ 「細胞構造研究の新展開」   19 Mar 2013   日本細菌学会
Structure, function and evolution of bacterial protein translocation machinery [Invited]
Mori H, Tsukazaki T, Akiyama Y, Nureki O, Ito K
第33回日本分子生物学会年会・第83回日本生化学会大会 合同大会ワークショップ「進化からみたタンパク質社会」   10 Dec 2010   日本分子生物学会・日本生化学会
Molecular mechanisms of SecA mediated protein translocation [Invited]
第47回日本生物物理学会年会 シンポジウム「蛋白質の膜透過輸送の最前線」   31 Oct 2009   日本生物物理学会
Functional dissection of bacterial Sec translocation machinery. [Invited]
Mori H., Tsukazaki T., Echizen Y., Ishitani R., Nureki O. and Ito K.
International Symposium Innovative Nanoscience of Supermolecular Motor Proteins Working in Biomembranes',Kyoto, Japan, September 8-10,2009   8 Sep 2009   
How does SecA ATPase interact with translocon and drive protein translocation? [Invited]
Mori H.
G-COE in Chemistry " Frontier of Organelle Dynamics and Protein Functions " March 11-13, Nagoya, Japan, 2008   12 Mar 2008   
Functional forms of SecA. [Invited]
Mori H.
International Symposium "Milestones in the Life of Proteins" 16 March, Kyoto 2007   2007   
How does SecA ATPase drive protein translocation? [Invited]
Mori H., Ito K.
The 14th East Asia Joint Symposium on Biomedical Research, November 14, 2007 Tokyo, Japan   2007   
Structure, function and regulation of the protein translocation machine of E. coli. [Invited]
Mori H., Ito K.
Discussion on Theory and Simulation of Biomolecular Nano-machines. December 12-16, Kobe, Japan,2006   2006   

Research Grants & Projects

 
Study on translocation mechanism of presecretory protein across the cytoplasmic membrane of ┣DBEscherichia coli(/)-┫DB