J-GLOBAL         Last updated: May 21, 2012 at 10:45
Tokyo Medical and Dental University
Graduate School of Medical and Dental Sciences
Job title
Associate Professor
Ph D(Tokyo University of Science)

Research Areas


Academic & Professional Experience

April 1993 - October 1998: Research Associate, Tokyo University of Science
November 1998 - November 1999: Lecturer, Tokyo Medical and Dental University
December 2000 - : Associate Professor, Tokyo Medical and Dental University


Department of Applied Biological Science, Graduate School, Division of Science and Engineering, Tokyo University of Science
Faculty of Applied Biological Science, Faculty of Science and Engineering, Tokyo University of Science

Published Papers

Fukuyo Y, Takahashi A, Hara E, Horikoshi N, Pandita T K, Nakajima T
International Journal of Oral Science   3(4) 200-208   Oct 2011   [Refereed]


Yayoi Fukuyo, Nobuo Horikoshi, Alexander Ishov, Saul J. Silverstein, Takuma Nakajima
Journal of Virology   85(7) 3356-3366   2011
2011 April
Fukuyo Y, Inoue M, Nakajima T, Higashikubo R, Horikoshi NT, Hunt C, Usheva A, Freeman ML, Horikoshi N
Cancer Res   68(15) 6324-6330   2008
2008 Aug 1
Tomi N, Fukuyo Y, Arakawa S, Nakajima T
J Periodont Res   43(2) 136-142   2008
2008 Apr
Nakajima T, Tomi N, Fukuyo Y, Ishikura H, Ohno Y, Arvind R, Arai T, Ishikawa I, Arakawa S
Biochem Biophys Res Commun   351(1) 133-139   2006
2006 Dec 8

Research Grants & Projects

Mechanisms of E2FBP1 mediated intrinsic cellular defense and the dissociation of promyelocytic leukemia protein nuclear bodies (PML-NBs) on the infection of human herpes simplex virus-1.
Project Year: 2004   
E2FBP1/hDRIL1, an A/T-rich DNA binding domain (ARID) family transcription factor is ubiquitously expressed in human tissues and plays an essential role in maintaining the proliferation potential of HDF cells through dissociating promyelocytic leuk...
Cell signaling that regulates E2FBP1 expression to suppress premature senescence.
Project Year: 2005   
E2FBP1/Dril1, an ARID3a transcription factor dissociates PML-NBs and this function is essential for maintaining proliferation potential of human passage-limited normal fibroblast (HDF) cells. However, neither how E2FBP1 dissociates PML-NBs nor ho...
Functions and effects of Forsythia detaching factor (FDF) on human cells
Project Year: 1999   
FDF is a recently isolated cytopathic factor from periodontopathic bacterium Tannerella forsythia. It is a cysteine protease cleaving target at the C-terminal side of Lysine residue and detach adherent human culture cells from substratum in the pr...
Secretion of forsythia detaching factor (FDF) from Tannerella forsythia.
Project Year: 2008   
FDF is expressed as an inactive form and is activated after removal of N-terminal half. The cleavage site is immediate C-terminal side of a lysine residue, however, the mechanism how, and the timing when FDF is cleaved and activated remain to be e...