論文

査読有り
2018年3月1日

Psychological interventions for positive symptoms in schizophrenia: Protocol for a network meta-Analysis of randomised controlled trials

BMJ Open
  • Irene Bighelli
  • ,
  • Georgia Salanti
  • ,
  • Cornelia Reitmeir
  • ,
  • Sofia Wallis
  • ,
  • Corrado Barbui
  • ,
  • Toshi A Furukawa
  • ,
  • Stefan Leucht

8
3
開始ページ
e019280
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1136/bmjopen-2017-019280
出版者・発行元
BMJ Publishing Group

Introduction There is rising awareness that we need multidisciplinary approaches integrating psychological treatments for schizophrenia, but a comprehensive evidence based on their relative efficacy is lacking. We will conduct a network meta-Analysis (NMA), integrating direct and indirect comparisons from randomised controlled trials (RCTs) to rank psychological treatments for schizophrenia according to their efficacy, acceptability and tolerability. Methods and analysis We will include all RCTs comparing a psychological treatment aimed at positive symptoms of schizophrenia with another psychological intervention or with a no treatment condition (waiting-list and treatment as usual). We will include studies on adult patients with schizophrenia, excluding specific subpopulations (eg, first-episode patients or patients with psychiatric comorbidities). Primary outcome will be the change in positive symptoms on a published rating scale. Secondary outcomes will be acceptability (dropout), change in overall and negative symptoms of schizophrenia, response, relapse, adherence, depression, quality of life, functioning and adverse events. Published and unpublished studies will be sought through database searches, trial registries and websites. Study selection and data extraction will be conducted by at least two independent reviewers. We will conduct random-effects NMA to synthesise all evidences for each outcome and obtain a comprehensive ranking of all treatments. NMA will be conducted in Stata and R within a frequentist framework. The risk of bias in studies will be evaluated using the Cochrane Risk of Bias tool and the credibility of the evidence will be evaluated using an adaptation of the Grading of Recommendations Assessment, Development and Evaluation framework to NMA, recommended by the Cochrane guidance. Subgroup and sensitivity analyses will be conducted to assess the robustness of the findings. Ethics and dissemination No ethical issues are foreseen. Results from this study will be published in peer-reviewed journals and presented at relevant conferences. PROSPERO registration number CRD42017067795.

リンク情報
DOI
https://doi.org/10.1136/bmjopen-2017-019280
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29540411
URL
http://orcid.org/0000-0003-2159-3776
ID情報
  • DOI : 10.1136/bmjopen-2017-019280
  • ISSN : 2044-6055
  • ORCIDのPut Code : 42621089
  • PubMed ID : 29540411
  • SCOPUS ID : 85044180977

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