2009年10月
EVIDENCE-BASED GUIDELINES FOR INTERPRETATION OF THE PANIC DISORDER SEVERITY SCALE
DEPRESSION AND ANXIETY
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- 巻
- 26
- 号
- 10
- 開始ページ
- 922
- 終了ページ
- 929
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1002/da.20532
- 出版者・発行元
- WILEY-LISS
Background: The Panic Disorder Severity Scale (PDSS) is promising to be a standard global rating scale for panic disorder. In order for a clinical scale to be useful, we need a guideline for interpreting its scores and their changes, and for defining clinical change points such as response and remission. Methods: We used individual patient data from two large randomized controlled trials of panic disorder (total n = 568). Study participants were administered the PDSS and the Clinical Global Impression (CGI)-Severity and -Improvement. We applied equipercentile linking technique to draw correspondences between PDSS and CGI-Severity, numeric changes in PDSS and CGI-Improvement, and percent changes in PDSS and CGI-Improvement. Results: The interpretation of the PDSS total score differed according to the presence or absence of agoraphobia. When the patients were not agoraphobic, score ranges 0-1 corresponded with "Normal," 2-5 with "Borderline," 6-9 with "Slightly ill, " 10-13 with "Moderately ill, " and 14 and above with "Markedly ill." When the patients were agoraphobic, score ranges 3-7 meant "Borderline ill," 8-10 "Slightly ill," 11-15 "Moderately ill," and 16 and above "Markedly ill. " The relationship between PDSS change and CGI-Improvement was more linear when measured as percentile change than as numeric changes, and was indistinguishable for those with or without agoraphobia. The decrease by 75-100% was considered "Very much improved," that by 40-74% "Much improved," and that by 10-39% "Minimally improved." Conclusion: We propose that "remission" of panic disorder be defined by PDSS scores of five or less and its "response" by 40% or greater reduction. Depression and Anxiety 26:922-929, 2009. (C) 2008 Wiley-Liss, Inc.
- リンク情報
- ID情報
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- DOI : 10.1002/da.20532
- ISSN : 1091-4269
- Web of Science ID : WOS:000270582000008