MISC

1996年5月

Enhancing effects of epidermal growth factor on human squamous cell carcinoma motility and matrix degradation but not growth

TUMOR BIOLOGY
  • T Shibata
  • ,
  • T Kawano
  • ,
  • H Nagayasu
  • ,
  • K Okumura
  • ,
  • M Arisue
  • ,
  • J Hamada
  • ,
  • N Takeichi
  • ,
  • M Hosokawa

17
3
開始ページ
168
終了ページ
175
記述言語
英語
掲載種別
出版者・発行元
KARGER

In order to ascertain the effects of epidermal growth factor (EGF) on human cancer invasion abilities, three cell lines of human oral squamous cell carcinoma were studied using a phagokinetic track assay and zymography. EGF(1-100 ng/ml) was found to inhibit the growth but enhance the random motility of all three cell lines in a concentration-dependent fashion. Exposure to EGF, dose-dependently, led to an increased production of urokinase-type plasminogen activator and M(r) 92 kD matrix metalloproteinase by the same cells, These results strongly suggest that EGF may promote human squamous cell carcinoma invasion and metastasis.

Web of Science ® 被引用回数 : 58

リンク情報
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:A1996UJ84700004&DestApp=WOS_CPL
ID情報
  • ISSN : 1010-4283
  • Web of Science ID : WOS:A1996UJ84700004

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