MISC

1998年1月

Reversible and irreversible tumor progression of a weakly malignant rat mammary carcinoma cell line by in vivo exposure to epidermal growth factor

INTERNATIONAL JOURNAL OF ONCOLOGY
  • H Nagayasu
  • ,
  • J Hamada
  • ,
  • D Nakata
  • ,
  • T Shibata
  • ,
  • M Kobayashi
  • ,
  • M Hosokawa
  • ,
  • N Takeichi

12
1
開始ページ
197
終了ページ
202
記述言語
英語
掲載種別
出版者・発行元
PROFESSOR D A SPANDIDOS

We examined the effects of epidermal growth factor (EGF) on tumor progression of a weakly malignant rat mammary carcinoma cell line, ER-1. In vitro treatment with EGF enhanced tumorigenicity, metastatic capacity and in vitro invasive capacity of ER-1 cells. The increased malignancy of ER-1 cells was reversible, when the cells were pretreated with EGF for 24 h, whereas it was irreversible when pretreated with EGF for 1 month. EGF treatment elevated the intracellular peroxide level in ER-1 cells. When ER-1 cells were treated with EGF in the presence of N-acetylcysteine, a chemical antioxidant, the reversible or irreversible EGF-induced progression was inhibited. These results suggest that the reversible or irreversible tumor progression in ER-1 cells occur in accordance with the duration of exposure to EGF, and that reactive oxygen species may be involved in the progression.

Web of Science ® 被引用回数 : 10

リンク情報
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000071163600024&DestApp=WOS_CPL
ID情報
  • ISSN : 1019-6439
  • Web of Science ID : WOS:000071163600024

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