1995
Adhesion-inducible DNA synthesis regulated by tyrosine phosphorylation/dephosphorylation
Biochemical and Biophysical Research Communications
- ,
- Volume
- 214
- Number
- 3
- First page
- 856
- Last page
- 860
- Language
- English
- Publishing type
- Research paper (scientific journal)
- DOI
- 10.1006/bbrc.1995.2365
Non-malignant rat liver epithelial cell line BRL was reported to adhere to a substrate by fibronectin. DNA synthesis of these cells was induced by adhesion to a substrate by fibronectin, while DNA synthesis in non-adhered cells was not observed. These results indicated that DNA synthesis in BRL cells is inducible by the cell adhesion signaling. Adhesion-inducible DNA synthesis was strongly inhibited by Herbimycin A. In contrast, vanadate showed the tendency to promote adhesion-inducible DNA synthesis. These results suggest that DNA synthesis caused by the cell adhesion in these cells was regulated by both phosphorylation and dephosphorylation at tyrosine residue. © 1995 by Academic Press, Inc.
- Link information
- ID information
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- DOI : 10.1006/bbrc.1995.2365
- ISSN : 0006-291X
- SCOPUS ID : 0028881119