Dec, 2002
Autoantibody-mediated atherosclerosis
Autoimmunity Reviews
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- ,
- ,
- Volume
- 1
- Number
- 6
- First page
- 348
- Last page
- 353
- Language
- English
- Publishing type
- Research paper (scientific journal)
- DOI
- 10.1016/S1568-9972(02)00084-8
β2-Glycoprotein I (β2-GPI) is a major antigen for antiphospholipid antibodies (aPL) present in patients with antiphospholipid syndrome (APS). Oxidized low-density lipoprotein (oxLDL) is subsequently targeted by β2-GPI and anti-β2-GPI autoantibodies. Ligands specific for β2-GPI derived from oxLDL have been characterized as oxidized forms of cholesteryl linoleate, such as 7-ketocholesterol-9-carboxynonanoate, i.e. 9-oxo-9-(7-ketocholest-5-en-3β- yloxy) nonanoic acid, (namely oxLig-1). The in vitro phenomenon that it is significantly increased in binding of oxLig-1 containing liposomes to macrophages via an interaction with β2-GPI and an anti-β2-GPI autoantibody (via the Fcγ receptor) may propose a novel mechanism on 'autoantibody-mediated athrosclerosis'. Furthermore, autoantibodies against a complex of β2-GPI and oxLig-1 are detected in sera of APS patients and appearance of the antibodies is associated with episodes of thrombosis, especially, arterial thrombosis. Thus, autoimmune atherogenesis linked to β2-GPI interaction with oxLDL and autoantibodies may be present in APS. © 2002 Elsevier Science B.V. All rights reserved.
- Link information
- ID information
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- DOI : 10.1016/S1568-9972(02)00084-8
- ISSN : 1568-9972
- Pubmed ID : 12848990
- SCOPUS ID : 0037802819