HASEBE Akira

J-GLOBAL         Last updated: Oct 12, 2018 at 12:42
 
Avatar
Name
HASEBE Akira
URL
http://www.den.hokudai.ac.jp/saikin/index.html
Affiliation
Hokkaido University
Section
Graduate School of Dental Medicine, Division of Oral Medical Sciencece, Division of Oral Pathobiological Science

Research Areas

 
 

Published Papers

 
Hasebe A, Saeki A, Yoshida Y, Shibata KI
Archives of Oral Biology   93 115-125   Jun 2018   [Refereed]
Saeki A, Suzuki T, Hasebe A, Kamezaki R, Fujita M, Nakazawa F, Shibata KI
Cellular microbiology   19(3)    Mar 2017   [Refereed]
Nakamura K, Nakanishi K, Bando Y, Hasebe A, Hyono A, Abe S, Shibata K, Yoshida Y, Iida J, Yawaka Y
Nano Biomedicine   9(1) 29-34   Jan 2017   [Refereed]
Sugiyama M, Saeki A, Hasebe A, Kamesaki R, Yoshida Y, Kitagawa Y, Suzuki T, Shibata K
Molecular Oral Microbiology   31(3) 259-269   Jun 2016   [Refereed]
Oouchi M, Hasebe A, Hata H, Segawa T, Yamazaki Y, Yoshida Y, Kitagawa Y, Shibata KI
Oral Diseases   21(5) 645-651   Jul 2015   [Refereed]
阿部亜美, 佐伯歩, 長谷部晃, 原博志, 八若保孝, 柴田健一郎
北海道歯学雑誌   35(2) 123-132   Mar 2015
インフラマソームは多様な生理活性をもつ炎症性サイトカインのひとつであるIL-1βの産生を制御する細胞内センサーである。近年、IL-1βが関与する炎症性疾患の多くがこの細胞内センサーの活性化と関連している可能性が示唆され、病態解明の手がかりとしてインフラマソームが注目されている。歯周炎はその病態形成にIL-1βが重要な役割を果たすが、歯周炎とインフラマソームとの関連を示した報告はほとんどない。そこで、本研究では、侵襲性歯周炎の主な病原菌であり、感染性心内膜炎や敗血症などの全身疾患との関連も多...
原博志, 長谷部晃, 佐伯歩, 阿部亜美, 山崎裕, 柴田健一郎
北海道歯学雑誌   35(1) 16-24   Sep 2014
我々は、これまでにToll-like receptor 2(TLR2)のリガンドであるリポペプチドFSL-1がin vivoにおいてTLR2依存的な抗腫瘍活性を示すこと、また、口腔レンサ球菌の全菌体の認識にTLR2が重要な役割を果たしていることを明らかにした。そこで、本研究では口腔レンサ球菌の全菌体のin vivoにおける抗腫瘍活性を検証した。8-9週齢のC57BL/6マウスの背部皮下にメラノーマB16F0を接種後、4日後及び9日後に、Streptococcus gordoniiの生菌ある...
谷詰直穂, 大谷誠, 長谷部晃, 佐伯歩, 戸塚靖則, 鄭漢忠, 柴田健一郎
北海道歯学雑誌   35(1) 8-15   Sep 2014
TLRは自然免疫系で病原体の侵入を感知するだけでなく、T細胞が中心的な役割を果たす獲得免疫の誘導においても重要な役割を果たしている。これまで、T細胞自身もTLRを発現していることが明らかになっているが、T細胞の機能におけるTLRの役割はいまだ不明な点が多く残されている。本研究では、T細胞受容体を介したT細胞の活性化で重要な役割を果たしているSrcファミリーキナーゼのひとつであるLckに注目し、TLR2とLckのクロストークを検討した。C57BL/6マウスのCD4陽性T細胞を抗CD3ε抗体お...
Hasebe A, Mu HH, Cole BC
American journal of reproductive immunology (New York, N.Y. : 1989)   72(3) 285-295   Sep 2014   [Refereed]
Segawa T, Saeki A, Hasebe A, Arimoto T, Kataoka H, Yokoyama A, Kawanami M, Shibata K
Pathogens and disease   68 65-77   Aug 2013   [Refereed]
Hasebe A, Ishikawa I, Shamsul HM, Ohtani M, Segawa T, Saeki A, Tanizume N, Oouchi M, Okagami Y, Okano T, Shibata K
Photomedicine and laser surgery   31 125-131   Mar 2013   [Refereed]
Saeki A, Segawa T, Abe T, Sugiyama M, Arimoto T, Hara H, Hasebe A, Ohtani M, Tanizume N, Ohuchi M, Kataoka H, Kawanami M, Yokoyama A, Shibata K.
Molecular Oral Microbiology   28 267-280   Feb 2013   [Refereed]
Kiura K, Hasebe A, Saeki A, Segawa T, Okada F, Shamsul HM, Ohtani M, Into T, Inoue N, Wakita M, Shibata K
Immunobiology   216 891-900   Aug 2011   [Refereed]
Mu HH, Hasebe A, Van Schelt A, Cole BC
Cellular microbiology   13 374-387   Mar 2011   [Refereed]
Shamsul HM, Hasebe A, Iyori M, Ohtani M, Kiura K, Zhang D, Totsuka Y, Shibata K
Immunology   130 262-272   Jun 2010   [Refereed]
Relationship of expression and function of Toll-like receptor 2 and 4 with aging in human and mouse.
Donen M, Ohtani M, Kiura K, Saeki A, Tanizume N, Hasebe A, Totsuka Y, Shibata K.
Hokkaido Journal of Dental Science   31 82-89   2010   [Refereed]
Iyori M, Ohtani M, Hasebe A, Totsuka Y, Shibata K
Biochemical and biophysical research communications   377 367-372   Dec 2008   [Refereed]
Iyori M, Kataoka H, Shamsul HM, Kiura K, Yasuda M, Nakata T, Hasebe A, Shibata K
Antimicrobial agents and chemotherapy   52 121-127   Jan 2008   [Refereed]
Hasebe A, Mu HH, Washburn LR, Chan FV, Pennock ND, Taylor ML, Cole BC
Infection and immunity   75(4) 1820-1826   Apr 2007   [Refereed]
Mae M, Iyori M, Yasuda M, Shamsul HM, Kataoka H, Kiura K, Hasebe A, Totsuka Y, Shibata K
FEMS immunology and medical microbiology   49 398-409   Apr 2007   [Refereed]
Hasebe A, Pennock ND, Mu HH, Chan FV, Taylor ML, Cole BC
Journal of Immunology   177 4826-4832   Oct 2006   [Refereed]
Cole BC, Mu HH, Pennock ND, Hasebe A, Chan FV, Washburn LR, Peltier MR
Infection and immunity   73 6039-6047   Sep 2005   [Refereed]
Hasebe A, Yoshimura A, Into T, Kataoka H, Tanaka S, Arakawa S, Ishikura H, Golenbock DT, Sugaya T, Tsuchida N, Kawanami M, Hara Y, Shibata K
Infection and immunity   72 1318-1325   Mar 2004   [Refereed]
Okusawa T, Fujita M, Nakamura J, Into T, Yasuda M, Yoshimura A, Hara Y, Hasebe A, Golenbock DT, Morita M, Kuroki Y, Ogawa T, Shibata K
Infection and immunity   72 1657-1665   Mar 2004   [Refereed]
Into T, Kiura K, Yasuda M, Kataoka H, Inoue N, Hasebe A, Takeda K, Akira S, Shibata K
Cellular microbiology   6 187-199   Feb 2004   [Refereed]
Into T, Fujita M, Okusawa T, Hasebe A, Morita M, Shibata K
Infection and immunity   70 3586-3591   Jul 2002   [Refereed]
Into T, Nodasaka Y, Hasebe A, Okuzawa T, Nakamura J, Ohata N, Shibata K
Microbiology and immunology   46 265-276   2002   [Refereed]
Nakamura J, Shibata K, Hasebe A, Into T, Watanabe T, Ohata N
Microbiology and immunology   46 151-158   2002   [Refereed]
Hasebe A, Shibata K, Domon H, Dong L, Watanabe T.
Microbiology and Immunology   43(11) 1003-1008   1999   [Refereed]
Dong L, Shibata K, Sawa Y, Hasebe A, Yamaoka Y, Yoshida S, Watanabe T.
Infection and Immunity   67(6) 3061-3065   1999   [Refereed]
Shibata K, Kaga M, Kudo M, Dong L, Hasebe A, Domon H, Sato Y, Oguchi H, Watanabe T.
Microbiology and Immunology   43(6) 521-525   1999   [Refereed]
Watanabe T, Shibata K, Yoshikawa T, Dong L, Hasebe A, Domon H, Kobayashi T, Totsuka Y.
FEMS Immunology and Medical Microbiology   22 241-246   1998   [Refereed]
Shibata K, Hasebe A, Sasaki T, Watanabe T.
FEMS Immunology and Medical Microbiology   19 275-283   1997   [Refereed]

Misc

 
長谷部晃, 柴田健一郎
北海道歯学雑誌   32(2) 230-232   Mar 2012
The uptake mechanism of TLR2 ligands
HASEBE Akira, SHAMSUL Haque M, SHIBATA Ken-ichiro
50 162-166   2008   [Invited]

Conference Activities & Talks

 
The uptake manner of the diacylated lipopeptide FSL-1 by macrophages [Invited]
HASEBE Akira
Innate Immunity Symposium, Regulation in Innate Immunity - from Recognition Molecules to Antimicrobial Peptides.   29 Oct 2008   

Research Grants & Projects

 
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(若手研究(B))
Project Year: 2009 - 2010    Investigator(s): Akira HASEBE
To study the roles of bacterial lipoproteins on bacterial invasion to host cells and on the effects on intracellular trafficking in host cells, attempts were made to purify a mycoplasmal lipoprotein, since some mycoplasmas are known to be able to ...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2007 - 2009    Investigator(s): Kenichiro SHIBATA
Hosts recognize microbial invasion and then kill them intracellularily. In this study, we demonstrated that the signal mediated by a sensor that recognize bacterial invasion was suppressed by that by phagocytic receptor.
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2007 - 2008    Investigator(s): 木浦 和人
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(若手研究(B))
Project Year: 2007 - 2008    Investigator(s): Akira HASEBE
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 1998 - 1999    Investigator(s): Ken-ichiro SHIBATA
A lipoprotein with a molecular mass of 44 kDa (Lp44) in Mycopiasma lipoproteins possessed the ICAM-1 expression-inducing activity. The N-terminal amino acid sequence of Lp44 was suggested to be CGDPKH-PKSFTEWVA - and the amino group of the N- term...