IWATA Hisato

J-GLOBAL         Last updated: Jan 16, 2019 at 10:56
 
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Name
IWATA Hisato
Affiliation
Ehime University
Section
Center for Marine Environmental Studies
Job title
Professor,Faculty of Agriculture, Professor
Degree
Ph.D.(Ehime University)
Research funding number
10271652

Research Areas

 
 

Academic & Professional Experience

 
Apr 2017
 - 
Today
Leading Academia in Marine and Environment Pollution Research (LaMer)
 
1999
 - 
2000
Postdoctoral Fellow (JSPS PD), Department of Biology, Woods Hole Oceanographic Institution
 

Awards & Honors

 
2011
Biwako Prize For Ecology
 
2009
15th Pollutants Response in Marine Organisms (PRIMO15) Best Presentation Award
 
2006
International Symposium 2006; Pioneering Studies of Young Scientists on Chemical Pollution and Environmental Changes Best Presentation Award
 
2005
13th Pollutants Response in Marine Organisms (PRIMO13) Best Presentation Award
 
2004
7th International Symposium on Cytochrome P-450 Biodiversity and Biotechnology 優秀ポスター賞
 
2004
1st International Symposium on Environmental Behavior and Ecological Impacts of Persistent Toxic Substances ベストポスター賞
 
1994
QUINTESSENCE, Excellence in Environmental Contamination and Toxicology, SCIPRESS
 

Published Papers

 
Guo J, Nguyen HT, Ito S, Yamamoto K, Kanerva M, Iwata H
Ecotoxicology and Environmental Safety   165 495-504   Dec 2018   [Refereed]
Eguchi A, Nomiyama K, Sakurai K, Kim Trang PT, Viet PH, Takahashi S, Iwata H, Tanabe S, Todaka E, Mori C
Environmental Pollution   242 98-105   Nov 2018   [Refereed]
Ochiai M, Iida M, Agusa T, Takaguchi K, Fujii S, Nomiyama K, Iwata H
Toxicological Sciences   165(1) 118-130   Sep 2018   [Refereed]
Guo J, Ito S, Nguyen HT, Yamamoto K, Iwata H
Ecotoxicology and Environmental Safety   160 94-103   Sep 2018   [Refereed]
Ishibashi H, Kim EY, Arizono K, Iwata H
Environmental Science & Technology   52 11831-11837   Sep 2018   [Refereed]
Hirakawa S, Miyawaki T, Hori T, Kajiwara J, Katsuki S, Hirano M, Yoshinouchi Y, Iwata H, Mitoma C, Furue M
Environmental Science and Pollution Research International   25(17) 16455-16463   Jun 2018   [Refereed]
Guo J, Ito S, Nguyen HT, Yamamoto K, Tanoue R, Kunisue T, Iwata H
Toxicology and Applied Pharmacology   347 23-32   May 2018   [Refereed]
Gamboa M, Tsuchiya MC, Matsumoto S, Iwata H, Watanabe K
Archives of Insect Biochemistry and Physiology   96(3)    Nov 2017   [Refereed]
Guo J, Iwata H
Ecotoxicology and Environmental Safety   143 111-119   Sep 2017   [Refereed]
Ochiai M, Nomiyama K, Isobe T, Yamada TK, Tajima Y, Matsuda A, Shiozaki A, Matsuishi T, Amano M, Iwata H, Tanabe S
Marine Environmental Research   128 124-132   Jul 2017   [Refereed]
Hoa Thanh Nguyen, Maria Claret Lauan Tsuchiya, Maria Claret Lauan Tsuchiya, Jean Yoo, Midori Iida, Tetsuro Agusa, Tetsuro Agusa, Masashi Hirano, Eun Young Kim, Tatsuhiko Miyazaki, Masato Nose, Hisato Iwata
Archives of Toxicology   91 1763-1782   Apr 2017
© 2016, Springer-Verlag Berlin Heidelberg. Dioxins cause various toxic effects through the aryl hydrocarbon receptor (AHR) in vertebrates, with dramatic species and strain differences in susceptibility. Although inbred mouse strains C3H/HeJ-lpr/lp...
Su Min Bak, Su Min Bak, Midori Iida, Anatoly A. Soshilov, Michael S. Denison, Hisato Iwata, Eun Young Kim, Eun Young Kim
Archives of Toxicology   91 301-312   Jan 2017
© 2016, Springer-Verlag Berlin Heidelberg. The toxic effects of dioxins and related compounds (DRCs) are mediated by the aryl hydrocarbon receptor (AHR). Our previous study identified AHR1 and AHR2 genes from the red seabream (Pagrus major). Moreo...
In Sung Kim, Ji Hee Hwang, Ji Hee Hwang, Masashi Hirano, Hisato Iwata, Eun Young Kim, Eun Young Kim
Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology   187 1-9   Sep 2016
© 2016 Published by Elsevier Inc. Aryl hydrocarbon receptor (AHR) is well conserved from invertebrates to vertebrates, and it mediates the toxic effects of exogenous ligands, including dioxins. Recent studies reported that AHRs activated by endoge...
Midori Iida, Midori Iida, Satoshi Fujii, Masaya Uchida, Hiroshi Nakamura, Yoshihiro Kagami, Tetsuro Agusa, Masashi Hirano, Su Min Bak, Eun Young Kim, Hisato Iwata
Aquatic Toxicology   177 156-170   Aug 2016
© 2016 Elsevier B.V. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induces a broad spectrum of toxic effects including craniofacial malformation and neural damage in fish embryos. These effects are mainly mediated by the aryl hydrocarbon receptor (AH...
Ji Hee Hwang, Jin Young Park, Hae Jeong Park, Su Min Bak, Masashi Hirano, Hisato Iwata, Young Suk Park, Eun Young Kim
Scientific Reports   6    Jun 2016
The aryl hydrocarbon receptor (AHR) mediates dioxin toxicities. Several studies have suggested that two amino acid residues corresponding to the 324 th and 380 th positions in the ligand binding domain (LBD) of the chicken AHR1 (Ile-Ser as high se...
Junko Fujihara, Toshihiro Yasuda, Hisato Iwata, Shinsuke Tanabe, Haruo Takeshita
Archives of Toxicology   90 1009-1012   Apr 2016
© 2015, Springer-Verlag Berlin Heidelberg. The associations of four single nucleotide polymorphisms (p.Arg194Trp, p.Arg280His, p.Pro206Pro, and p.Arg399Gln) in X-ray repair cross-complementing group 1 with urinary arsenic metabolites and 8-hydroxy...
Hazuki Mizukawa, Hazuki Mizukawa, Kei Nomiyama, Susumu Nakatsu, Hisato Iwata, Jean Yoo, Akira Kubota, Miyuki Yamamoto, Mayumi Ishizuka, Yoshinori Ikenaka, Shouta M.M. Nakayama, Tatsuya Kunisue, Shinsuke Tanabe
Environmental Science and Technology   50 444-452   Jan 2016
© 2015 American Chemical Society. There are growing concerns about the increase in hyperthyroidism in pet cats due to exposure to organohalogen contaminants and their hydroxylated metabolites. This study investigated the blood contaminants polychl...
Jean Yoo, Masashi Hirano, Hazuki Mizukawa, Kei Nomiyama, Tetsuro Agusa, Eun Young Kim, Shinsuke Tanabe, Hisato Iwata
Environmental Science and Technology   49 14588-14596   Dec 2015
© 2015 American Chemical Society. The aim of this study was to understand the cytochrome P450 (CYP)-dependent metabolic pathway and potency of polychlorinated biphenyls (PCBs) in the Baikal seal (Pusa sibirica). In vitro metabolism of 62 PCB conge...
See Wun Cho, See Wun Cho, Ken ichi Suzuki, Yoshiaki Miura, Tatsuhiko Miyazaki, Masato Nose, Masato Nose, Hisato Iwata, Eun Young Kim, Eun Young Kim
Archives of Toxicology   89 2027-2038   Nov 2015
© 2014, Springer-Verlag Berlin Heidelberg. The aryl hydrocarbon receptor (AHR) is responsible for susceptibility to its ligand-dependent responses. However, the effect of non-AHR factors is less clear. To explore the non-AHR factors, we used two m...
Hisato Iwata, Keisuke Yamaguchi, Yoko Takeshita, Akira Kubota, Shusaku Hirakawa, Tomohiko Isobe, Masashi Hirano, Eun Young Kim
Aquatic Toxicology   162 138-151   May 2015
© 2015 Elsevier B.V. This study aimed to elucidate the catalytic function of cytochrome P450 (CYP) 1 enzymes in aquatic mammals. Alkoxyresorufin O-dealkylation (AROD) activities including methoxy- (MROD), ethoxy- (EROD), pentoxy- (PROD), and benzy...
Hazuki Mizukawa, Kei Nomiyama, Tatsuya Kunisue, Michio X. Watanabe, Annamalai Subramanian, Hisato Iwata, Mayumi Ishizuka, Shinsuke Tanabe
Environmental Research   138 255-263   Apr 2015
© 2015 Elsevier Inc. The concentrations of polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), and their hydroxylated metabolites (OH-PCBs and OH-PBDEs) were measured in the blood of Eurasian wild pigs (Sus scrofa) from a mun...
Masashi Hirano, Ji Hee Hwang, Hae Jeong Park, Su Min Bak, Hisato Iwata, Eun Young Kim
Environmental Science and Technology   49 3795-3804   Mar 2015
© 2015 American Chemical Society. The aryl hydrocarbon receptor (AHR) mediates toxic responses to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and other dioxin-like compounds (DLCs). Avian species possess multiple AHR isoforms (AHR1, AHR1β, and AHR2...
Mikiko Soejima, Tetsuro Agusa, Hisato Iwata, Junko Fujihara, Takashi Kunito, Haruo Takeshita, Vi Thi Mai Lan, Tu Binh Minh, Shin Takahashi, Pham Thi Kim Trang, Pham Hung Viet, Shinsuke Tanabe, Yoshiro Koda
Legal Medicine   17 14-16   Jan 2015
© 2014 Elsevier Ireland Ltd. The haptoglobin (HP) gene deletion allele (HPdel) is responsible for anhaptoglobinemia and a genetic risk factor for anaphylaxis reaction after transfusion due to production of the anti-HP antibody. The distribution of...
Tetsuro Agusa, Takashi Kunito, Nguyen Minh Tue, Vi Thi Mai Lan, Tu Binh Minh, Pham Thi Kim Trang, Junko Fujihara, Haruo Takeshita, Shin Takahashi, Pham Hung Viet, Shinsuke Tanabe, Hisato Iwata
Nihon eiseigaku zasshi. Japanese journal of hygiene   70 186-196   Jan 2015
Arsenic metabolism affects the susceptibility of humans to arsenic toxicity; therefore, clarification of the factors associated with individual variations in arsenic metabolism is an important task. Genetic polymorphisms such as single nucleotide ...
Kei Nomiyama, Shusaku Hirakawa, Akifumi Eguchi, Chika Kanbara, Daisuke Imaeda, Jean Yoo, Tatsuya Kunisue, Eun Young Kim, Hisato Iwata, Shinsuke Tanabe
Environmental Science and Technology   48 13530-13539   Nov 2014
© 2014 American Chemical Society. We have previously reported that high accumulation of dioxins and related compounds induced cytochrome P450 (CYP 1s) isozymes in the liver of wild Baikal seals, implying the enhanced hydroxylation of polychlorinat...
Midori Iida, Midori Iida, Su Min Bak, Su Min Bak, Yasunori Murakami, Eun Young Kim, Eun Young Kim, Hisato Iwata
Aquatic Toxicology   154 39-47   Jan 2014
The toxicity of dioxins such as 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) is mainly mediated by an aryl hydrocarbon receptor (AHR), which regulates the transcription of multiple target genes including cytochrome P450 1A (CYP1A). Our pervious stu...
Daisuke Imaeda, Kei Nomiyama, Tatsuya Kunisue, Hisato Iwata, Oyuna Tsydenova, Masao Amano, Evgeny A. Petrov, Valeriy B. Batoev, Shinsuke Tanabe
Chemosphere   114 1-8   Jan 2014
We have previously demonstrated that Baikal seals (Pusa sibirica) are still being exposed to polychlorinated biphenyls (PCBs), and the population is at risk. In the present study, we measured the residue levels of PCBs and their hydroxylated metab...
Satoko Niimi, Mai Imoto, Tatsuya Kunisue, Michio X. Watanabe, Eun Young Kim, Kei Nakayama, Genta Yasunaga, Yoshihiro Fujise, Shinsuke Tanabe, Hisato Iwata
Ecotoxicology and Environmental Safety   108 95-105   Jan 2014
Hepatic concentrations of persistent organochlorines (OCs) were determined in the common minke whale (Balaenoptera acutorostrata) from the North Pacific. To investigate the effects of OCs on the transcriptome in the minke whale, the present study ...
Jin Seon Lee, Kohei Iwabuchi, Koji Nomaru, Nobumasa Nagahama, Eun Young Kim, Hisato Iwata
Toxicological Sciences   136 450-466   Dec 2013
Dioxins including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) cause toxic effects through activation of the aryl hydrocarbon receptor (AHR)-mediated signaling pathway. Our previous studies have investigated the function of 2 AHR isoforms (AHR1 and ...
N. Fujisawa, W. S. Darwish, W. S. Darwish, Y. Ikenaka, E. Kim, J. Lee, H. Iwata, S. Nakayama, M. Ishizuka
Poultry Science   92 1921-1929   Jul 2013
A 1,000-fold difference has been reported in dioxin sensitivity between avian species. This difference is because the 2 amino acids in the type 1 aryl hydrocarbon receptor (AhR1), at positions 325 and 381, correspond to Leu324 and Ser380 in chicke...
Leena Mol Thuruthippallil, Akira Kubota, Eun Young Kim, Hisato Iwata
Environmental Science and Technology   47 6656-6663   Jun 2013
Our line of papers revealed that the common (great) cormorant (Phalacrocorax carbo) possesses two isoforms of the aryl hydrocarbon receptor (ccAHR1 and ccAHR2). This paper addresses in vitro tests of the ccAHR signaling pathways to solve two quest...
Akira Kubota, Akira Kubota, Kumiko Yoneda, Shinsuke Tanabe, Hisato Iwata
Environmental Pollution   178 300-305   Apr 2013
This study focuses on gender-specific accumulation features of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/DFs) and dioxin-like polychlorinated biphenyls (DL-PCBs) in common (great) cormorants (Phalacrocorax carbo) collected from Lak...
Su Min Bak, Midori Iida, Masashi Hirano, Hisato Iwata, Eun Young Kim, Eun Young Kim
Environmental Science and Technology   47 2877-2885   Mar 2013
To evaluate species- and isoform-specific responses to dioxins and related compounds (DRCs) via aryl hydrocarbon receptor (AHR) in the red seabream (Pagrus major), we constructed a reporter gene assay system. Each expression plasmid of red seabrea...
Midori Iida, Eun Young Kim, Yasunori Murakami, Yasuhiro Shima, Hisato Iwata
Aquatic Toxicology   128-129 193-202   Mar 2013
We investigated 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced effects on the morphology of peripheral nervous system (PNS) in the developing red seabream (Pagrus major) embryos. The embryos at 10. h post-fertilization (hpf) were treated with ...
Michio X. Watanabe, Michio X. Watanabe, Tatsuya Kunisue, Norifumi Ueda, Masato Nose, Shinsuke Tanabe, Hisato Iwata
Environment International   53 53-61   Jan 2013
Concentrations of persistent organochlorine compounds (OCs) including polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and polychlorinated biphenyls (PCBs) in the liver and adipose tissue of Japanese cadavers were ...
Pham Thi Dau, Pham Thi Dau, Hiroki Sakai, Masashi Hirano, Hiroshi Ishibashi, Yuki Tanaka, Kenji Kameda, Takahiro Fujino, Eun Young Kim, Hisato Iwata
Toxicological Sciences   131 116-127   Jan 2013
The constitutive androstane receptor (CAR) not only displays a high basal transcriptional activity but also acts as a ligand-dependent transcriptional factor. It is known that CAR exhibits different ligand profiles across species. However, the mec...
Akira Kubota, Akira Kubota, Michio X. Watanabe, Eun Young Kim, Eun Young Kim, Kumiko Yoneda, Shinsuke Tanabe, Hisato Iwata
Environmental Pollution   168 131-137   Sep 2012
To validate the outcome of the national regulation on dioxins emission implemented in 1999, this study investigated temporal trends of chlorinated dioxins and related compounds (DRCs) in liver of common cormorants (Phalacrocorax carbo) collected f...
Mikiko Soejima, Ryo Fujimoto, Tetsuro Agusa, Hisato Iwata, Junko Fujihara, Haruo Takeshita, Tu Binh Minh, Pham Thi Kim Trang, Pham Hung Viet, Tamiko Nakajima, Joji Yoshimoto, Shinsuke Tanabe, Yoshiro Koda
Transfusion   52 1268-1275   Jun 2012
BACKGROUND: The human FUT2 gene encodes a secretor-type α(1,2)fucosyltransferase, and many population-specific polymorphisms have been reported in the coding region. STUDY DESIGN AND METHODS: Direct sequencing, real-time polymerase chain reaction,...
Nozomi Fujisawa, Yoshinori Ikenaka, Eun Young Kim, Jin Seon Lee, Hisato Iwata, Mayumi Ishizuka
European Journal of Wildlife Research   58 167-175   Feb 2012
Some wild populations of fish-eating birds and raptors are exposed to high concentrations of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds such as other 2,3,7,8-substituted polychlorinated dibenzo-p-dioxins and polychlorinated d...
Thuruthippallil Leena Mol, Eun Young Kim, Eun Young Kim, Hiroshi Ishibashi, Hisato Iwata
Environmental Science and Technology   46 525-533   Jan 2012
Our previous studies have detected high levels of dioxins and related compounds (DRCs) including polychlorinated dibenzo-p-dioxins (PCDDs), furans (PCDFs), and coplanar PCBs (Co-PCBs) in the black-footed albatross (BFA), Phoebastria nigripes, from...
Hiroki Teraoka, Shino Ito, Haruki Ikeda, Akira Kubota, Akira Kubota, Abou Elmagd M. M., Takio Kitazawa, Eun Young Kim, Eun Young Kim, Hisato Iwata, Daiji Endoh
Environmental Science and Technology   46 27-33   Jan 2012
To assess possible impacts of environmental pollutants on gene expression profiles in a variety of organisms, we developed a novel differential display system with primer sets that are common in seven vertebrate species, based on degenerate oligon...
Tetsuro Agusa, Takashi Kunito, Nguyen Minh Tue, Vi Thi Mai Lan, Junko Fujihara, Haruo Takeshita, Tu Binh Minh, Pham Thi Kim Trang, Shin Takahashi, Pham Hung Viet, Shinsuke Tanabe, Hisato Iwata
Metallomics   4 91-100   Jan 2012
We investigated the association of As exposure and genetic polymorphism in glutathione S-transferase π1 (GSTP1) with As metabolism in 190 local residents from the As contaminated groundwater areas in the Red River Delta, Vietnam. Total As concentr...
Tatsuya Kunisue, Tatsuya Kunisue, Akifumi Eguchi, Hisato Iwata, Shinsuke Tanabe, Kurunthachalam Kannan, Kurunthachalam Kannan, Kurunthachalam Kannan
Environmental Science and Technology   45 10140-10147   Dec 2011
Thyroid hormones (THs) are essential for the regulation of growth and development in both humans and wildlife. Until recently, TH concentrations in the tissues of animals have been examined by immunoassay (IA) methods. IA methods are sensitive, bu...
Junko Fujihara, Mikiko Soejima, Toshihiro Yasuda, Yoshiro Koda, Takashi Kunito, Hisato Iwata, Shinsuke Tanabe, Haruo Takeshita
Toxicology and Applied Pharmacology   256 174-178   Oct 2011
Arsenic causes DNA damage and changes the cellular capacity for DNA repair. Genes in the base excision repair (BER) pathway influence the generation and repair of oxidative lesions. Single nucleotide polymorphisms (SNPs) in human 8-oxoguanine DNA ...
Shusaku Hirakawa, Daisuke Imaeda, Kei Nakayama, Masayuki Udaka, Eun Young Kim, Eun Young Kim, Tatsuya Kunisue, Tatsuya Kunisue, Masako Ogawa, Tomonari Matsuda, Saburo Matsui, Evgeny A. Petrov, Valeriy B. Batoev, Shinsuke Tanabe, Hisato Iwata
Aquatic Toxicology   105 89-99   Sep 2011
We have previously indicated that accumulation of chlorinated dioxins and related compounds (DRCs) induced cytochrome P450 (CYP) 1A1, 1A2 and 1B1 isozymes in the liver of wild Baikal seals (Pusa sibirica). Here we attempt to assess the potential e...
Tetsuro Agusa, Tetsuro Agusa, Kozue Takagi, Todd W. Miller, Reiji Kubota, Yasumi Anan, Yasumi Anan, Hisato Iwata, Shinsuke Tanabe
Environmental Chemistry   8(1) 19-29   Aug 2011
Environmental context Although among higher marine animals, relatively high concentration of arsenic and unique distribution of arsenic compounds are found in green (Chelonia mydas) and hawksbill turtles (Eretmochelys imbricata), the accumulation ...
Tetsuro Agusa, Tetsuro Agusa, Shin ya Yasugi, Asami Iida, Tokutaka Ikemoto, Yasumi Anan, Yasumi Anan, Thijs Kuiken, Albert D.M.E. Osterhaus, Shinsuke Tanabe, Hisato Iwata
Marine Pollution Bulletin   62 963-975   May 2011
Body distribution and growth- and nutritional status-dependent accumulation of 21 trace elements were investigated in harbor seals (Phoca vitulina) stranded in the North Sea coast in 2002. Higher concentrations and burdens of Mn, Se, Mo, Ag, Sn, H...
Tetsuro Agusa, Tetsuro Agusa, Junko Fujihara, Haruo Takeshita, Hisato Iwata
International Journal of Molecular Sciences   12 2351-2382   Apr 2011
Individual variations in inorganic arsenic metabolism may influence the toxic effects. Arsenic (+3 oxidation state) methyltransferase (AS3MT) that can catalyze the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to trivalent arsen...
Hiroshi Ishibashi, Eun Young Kim, Hisato Iwata
Environmental Science and Technology   45 3123-3130   Apr 2011
The present study assessed the transactivation potencies of the Baikal seal (Pusa sibirica) peroxisome proliferator-activated receptor α (BS PPARα) by perfluorochemicals (PFCs) having various carbon chain lengths (C4-C12) using an in vitro reporte...
Tetsuro Agusa, Tetsuro Agusa, Kumiko Nomura, Takashi Kunito, Yasumi Anan, Hisato Iwata, Shinsuke Tanabe
Marine Pollution Bulletin   63 489-499   Mar 2011
Nineteen trace elements were determined in liver, muscle, kidney, gonads, and hair of 18 harp seals (Phoca groenlandica) from Pangnirtung in the Baffin Island, Canada. Concentrations of V, Mn, Fe, Cu, Mo, Ag, and Hg in the liver, Co, Cd, and Tl in...

Misc

 
ポリ塩化ビフェニル曝露によるイヌ・ネコの甲状腺ホルモン恒常性への影響
高口 倖暉, 野見山 桂, 西川 博之, 水川 葉月, 田上 瑠美, 草木 桃子, 横山 望, 市居 修, 滝口 満喜, 中山 翔太, 池中 良徳, 石塚 真由美, 岩田 久人, 国末 達也, 田辺 信介
The Journal of Toxicological Sciences   43(Suppl.) S245-S245   Jun 2018
ゼブラフィッシュを用いたビスフェノールA代替物質の内分泌攪乱作用の評価
久保田 彰, 李 宰承, 若山 裕己, 中村 倫子, 川合 佑典, 芳之内 結加, 岩田 久人, 平野 将司, 中田 晴彦
The Journal of Toxicological Sciences   43(Suppl.) S269-S269   Jun 2018
イヌ・アザラシ・マウスのエストロゲン受容体転写活性化能の種差を規定する分子機序
芳之内 結加, 奥田 博貴, 平野 将司, 野見山 桂, 田辺 信介, 金 恩英, 岩田 久人
環境ホルモン学会研究発表会要旨集   20回 41-41   Dec 2017
ゼブラフィッシュをモデルとしたin silicoおよびin vivo解析によるビスフェノール類のエストロゲン様作用の評価
久保田 彰, 若山 裕己, 中村 倫子, 川合 佑典, 芳之内 結加, 岩田 久人, 平野 将司, 中田 晴彦
環境ホルモン学会研究発表会要旨集   20回 65-65   Dec 2017
ビスフェノールAの出生前曝露によるニワトリ新生雛の肝臓トランスクリプトームへの影響の雌雄差
伊藤 匠平, 飯田 緑, Nguyen Thanh Hoa, 阿草 哲郎, 平野 将司, 落合 真理, 金 恩英, 岩田 久人
環境ホルモン学会研究発表会要旨集   20回 68-68   Dec 2017
妊娠中にビスフェノールAに曝露したラットの肝臓トランスクリプトーム分析 それらの産仔のトランスクリプトームとの比較(Hepatic transcriptome profiles of rats exposed to bisphenol A during pregnancy: comparison with those oftheir offspring)
Nguyen Hoa Thanh, Yamamoto Kimika, Iida Midori, Agusa Tetsuro, Hirano Masashi, Ochiai Mari, Kim Eun-Young, Iwata Hisato
環境ホルモン学会研究発表会要旨集   20回 74-74   Dec 2017
ニワトリ胚における肝臓トランスクリプトームから予想されるtriclosanの有害性評価(Hazard assessment of triclosan predicted from the liver transcriptome in chicken embryos)
Guo Jiahua, Ito Shohei, Nguyen Hoa Thanh, Yamamoto Kimika, Tanoue Rumi, Kunisue Tatsuya, Iwata Hisato
環境ホルモン学会研究発表会要旨集   20回 67-67   Dec 2017
水酸化PCBsによるアザラシ・イヌエストロゲン受容体転写活性化能の評価
芳之内 結加, 奥田 博貴, 平野 将司, 野見山 桂, 田辺 信介, 金 恩英, 岩田 久人
The Journal of Toxicological Sciences   42(Suppl.) S236-S236   Jun 2017
ゼブラフィッシュをモデルとしたin vivoおよびin silico解析によるビスフェノール類のエストロゲン様作用の評価
中村 倫子, 若山 裕己, 芳之内 結加, 森田 友里, 岩田 久人, 川合 佑典, 久保田 彰
The Journal of Toxicological Sciences   42(Suppl.) S271-S271   Jun 2017
有機リン系難燃剤およびその代謝物による発達期ゼブラフィッシュに対する影響
森田 友里, 若山 裕己, 芳之内 結加, 岩田 久人, 川合 佑典, 久保田 彰
The Journal of Toxicological Sciences   42(Suppl.) S271-S271   Jun 2017
PCBsのin vivo曝露によるビーグル犬の肝トランスクリプトームとメタボロームへの影響
田村 沙弥, 阿草 哲郎, 平野 将司, 江口 哲史, 野見山 桂, 田辺 信介, 金 恩英, 岩田 久人
環境ホルモン学会研究発表会要旨集   19回 80-80   Dec 2016
ビスフェノールAの出生前曝露によるニワトリ新生雛の肝臓トランスクリプトームへの影響
伊藤 匠平, 阿草 哲郎, 平野 将司, 落合 真理, 金 恩英, 岩田 久人
環境ホルモン学会研究発表会要旨集   19回 81-81   Dec 2016
ビスフェノールAの出生前曝露によるラット新生仔の体重・肝重量と肝遺伝子発現への影響
山本 季美花, Nguyen Thanh Hoa, 阿草 哲郎, 平野 将司, 落合 真理, 金 恩英, 岩田 久人
環境ホルモン学会研究発表会要旨集   19回 96-96   Dec 2016
出生前のビスフェノールA曝露がラットの産仔の異なる生育段階での肝臓トランスクリプトームに及ぼす影響(Effects of prenatal exposure to bisphenol A on hepatic transcriptome at different life stages of rat offspring)
Nguyen Thanh Hoa, Yamamoto Kimika, Agusa Tetsuro, Hirano Masashi, Ochiai Mari, Kim Eun-Young, Iwata Hisato
環境ホルモン学会研究発表会要旨集   19回 100-100   Dec 2016
鳥類のAHRと天然リガンドの相互作用のin silico/in vitro分析(In silico/in vitro analyses of the interaction of avian AHR and natural ligands)
Koh Dong-Hee, Iwata Hisato, Kim Eun-Young
環境ホルモン学会研究発表会要旨集   19回 91-91   Dec 2016
ホッキョクグマ(Ursus maritimus)のアリル炭化水素受容体(AHR)の分子特性(Molecular characterization of aryl hydrocarbon receptor(AHR) in Polar bears(Ursus maritimus))
Hwang Jihee, Kannan Kurunthachalam, Evans Thomas J., Iwata Hisato, Kim Eun-Young
環境ホルモン学会研究発表会要旨集   19回 83-83   Dec 2016
日本のダイオキシン・AHR研究最前線 どこまで実態が解ったか? ダイオキシン感受性および遺伝子型関連環境因子を判別するための鳥類のアリル炭化水素受容体の構造特性(Structural characteristics of avian aryl hydrocarbon receptors to decipher dioxin susceptibility and ecological factors related to their genotypes)
Hwang Ji-Hee, Park Hae-Jeong, Bak Su-Min, Hirano Masashi, Iwata Hisato, Park Jin-Young, Park Young-Suk, Kim Eun-Young
環境ホルモン学会研究発表会要旨集   19回 39-39   Dec 2016
日本のダイオキシン・AHR研究最前線 どこまで実態が解ったか? マダイにおけるアリル炭化水素受容体1(AHR1)およびAHR2によるAHR2遺伝子の自己誘導機構(Auto-induction mechanism of aryl hydrocarbon receptor 2(AHR2) gene by AHR1 and AHR2 in the red seabream)
Bak Su-Min, Iida Midori, Soshilov Anatoly A., Denison Michael S., Iwata Hisato, Kim Eun-Young
環境ホルモン学会研究発表会要旨集   19回 37-37   Dec 2016
「薬毒同源」のヒ素化合物 環境化学物質および医薬品としての二面性 無機ヒ素の代謝に関与する遺伝子多型
阿草 哲郎, 國頭 恭, Tue Nguyen Minh, Lan Vi Thi Mai, Minh Tu Binh, Trang Pham Thi Kim, 藤原 純子, 竹下 治男, 高橋 真, Viet Pham Hung, 田辺 信介, 岩田 久人
日本薬学会年会要旨集   136年会(1) 226-226   Mar 2016
イヌ脳に及ぼすPCBsの影響 プロテオーム解析による評価
高口 倖暉, 野見山 桂, Lauan Maria Claret, Yoo Jean, 水川 葉月, 岩田 久人, 国末 達也, 田辺 信介
環境ホルモン学会研究発表会要旨集   18回 106-106   Dec 2015
トランスクリプトーム解析によるPCBsを曝露したイヌへの影響評価
田村 沙弥, 劉 珍, 水川 葉月, 阿草 哲郎, 平野 将司, 江口 哲史, 野見山 桂, 田辺 信介, 金 恩英, 岩田 久人
環境ホルモン学会研究発表会要旨集   18回 116-116   Dec 2015
イヌ脳中PCBs、OH-PCBsの毒性影響評価 メタボロミクスアプローチ
野見山 桂, 江口 哲史, 水川 葉月, Yoo Jean, 高口 倖暉, 山本 泰央, 国末 達也, 岩田 久人, 田辺 信介
環境ホルモン学会研究発表会要旨集   18回 117-117   Dec 2015
OH-PCBsによるバイカルアザラシエストロゲン受容体α・β転写活性化能の評価
芳之内 結加, 平野 将司, 野見山 桂, 田辺 信介, 金 恩英, 岩田 久人
環境ホルモン学会研究発表会要旨集   18回 142-142   Dec 2015
アミecdysteroid受容体シグナル伝達に及ぼすPPCPsの影響についてのin silicoおよびin vitroスクリーニング(In silico and in vitro screening of the effects of PPCPs on mysid ecdysteroid receptor signaling)
Hirano Masashi, Ohno Yuki, Iwata Hisato
環境ホルモン学会研究発表会要旨集   18回 110-110   Dec 2015
ラット産仔の肝臓トランスクリプトームに及ぼす出生前のビスフェノールAへの曝露の影響(Effects of prenatal exposure to bisphenol A on the liver transcriptome of rat offspring)
Nguyen Thanh Hoa, Yamamoto Kimika, Agusa Tetsuro, Hirano Masashi, Ochiai Mari, Kim Eun-Young, Iwata Hisato
環境ホルモン学会研究発表会要旨集   18回 105-105   Dec 2015
【環境発がんと衛生〜ヒ素研究の視点から〜】 Arsenic(+3 Oxidation State)Methyltransferase(AS3MT)遺伝子多型と無機ヒ素のメチル化能力との関連
阿草 哲郎, 國頭 恭, Nguyen Minh Tue, Vi Thi Mai Lan, Tu Binh Minh, Pham Thi Kim Trang, 藤原 純子, 竹下 治男, 高橋 真, Pham Hung Viet, 田辺 信介, 岩田 久人
日本衛生学雑誌   70(3) 186-196   Sep 2015
ヒ素代謝酵素の一塩基多型(SNP)を解析することにより、個人・集団レベルでヒ素代謝の変動、そしてヒ素の毒性影響を評価することができる。ヒトにおいて体内に取り込まれた無機ヒ素(IA)は代謝され、排泄される。その代謝経路については、主に2つの酵素が主要な役割を担っていると考えられる。その一つAS3MTはIAを2段階のステップを経てメチル化する。AS3MTのSNPとヒ素代謝との関連について、過去のin vivoおよび疫学的調査の報告とこれまでの研究結果についてまとめた。
ベトナム人のハプトグロビン(HP)多型解析とHP欠失アリルHPdelの地理的分布
副島 美貴子, 神田 芳郎, 阿草 哲郎, 岩田 久人, 田辺 信介, 藤原 純子, 竹下 治男, 國頭 恭, Vi Thi Mai Lan, Tu Binh Minh, Pham Thi Kim Trang, Pham Hung Viet, 高橋 真
DNA多型   23(1) 108-111   Jul 2015
ベトナム人のハプトグロビン(HP)多型解析及びHP欠失アリルHPdelの地理的分布について検討した。試料はベトナ紅河デルタ地区の居住者293名の血液から抽出したゲノムDNAとし、TaqMan probe法に基づくHP2に特異的な配列とコントロール配列の比較C1法により、HP common多型とHPdelの同時検出を行った。サンプルを2AACT sampleの数値で分類した結果、HP型の遺伝子型は、-0.47〜0.37のHP2/HP2は144、0.64〜1.54のHP2/HP1は111、HP...
Species Differences in Xenobiotic/Drug Metabolism 異物/薬物代謝の種差解明の最先端 鳥類の化学物質感受性を規定する分子機序
岩田 久人, 平野 将司, 金 恩英
The Journal of Toxicological Sciences   40(Suppl.) S69-S69   Jun 2015
Soejima Mikiko, Agusa Tetsuro, Iwata Hisato, Fujihara Junko, Kunito Takashi, Takeshita Haruo, Vi Thi Mai Lan, Tu Binh Minh, Takahashi Shin, Pham Thi Kim Trang, Pham Hung Viet, Tanabe Shinsuke, Koda Yoshiro
Legal Medicine   17(1) 14-16   Jan 2015
ハプトグロビン(HP)遺伝子欠損対立遺伝子(HP del)は、無ハプトグロビン血症を引き起こし、輸血後の抗HP抗体産生によるアナフィラキシーの遺伝的危険因子である。この対立遺伝子の分布について、293名のベトナム人を対象にHP delの出現頻度を調査した。HP遺伝子型はリアルタイムPCRで決定した。HP1/HP1型が26名、HP1/HP2型が111名、HP1/HPdelが4名、HP2/HPdelが8名で、HPdelの出現頻度は0.020(12/586)であった。既に報告されているこの対立遺...
バイカルアザラシ エストロゲン受容体α・β転写活性化能の評価 種差とE2誘導等価係数
芳之内 結加, 清水 沙千子, 李 鎭善, 平野 将司, 阿草 哲郎, 鈴木 賢一, 中田 晴彦, 金 恩英, 岩田 久人
環境ホルモン学会研究発表会要旨集   17回 53-53   Dec 2014
パスウェイ解析によるTCDD曝露したマダイ胚のトランスクリプトームへの影響評価
飯田 緑, 藤井 聡, 内田 雅也, 中村 浩, 鏡 良弘, Bak Su-Min, 金 恩英, 岩田 久人
環境ホルモン学会研究発表会要旨集   17回 88-88   Dec 2014
ポリ塩化ビフェニル(PCBs)曝露によるイヌ異物代謝酵素シトクロムP450への影響
田村 沙弥, Yoo Jean, 水川 葉月, 阿草 哲郎, 平野 将司, 野見山 桂, 田辺 信介, 金 恩英, 岩田 久人
環境ホルモン学会研究発表会要旨集   17回 106-106   Dec 2014
バイカルアザラシ(Pusa sibira)における水酸化PCBsの毒性影響評価
野見山 桂, 平川 周作, 江口 哲史, 今枝 大輔, Yoo Jean, 国末 達也, 岩田 久人, 田辺 信介
環境ホルモン学会研究発表会要旨集   17回 107-107   Dec 2014
バイカルアザラシエストロゲン受容体α・β転写活性化能の評価 in vitro・in silico法によるリガンド作用機序の解明
芳之内 結加, 清水 沙千子, 李 鎭善, 平野 将司, 阿草 哲郎, 鈴木 賢一, 中田 晴彦, 金 恩英, 岩田 久人
環境ホルモン学会研究発表会要旨集   17回 113-113   Dec 2014
Ecdyson受容体シグナル伝達経路の新規調節因子としてのclathrinの機能的特性(Functional characterization of the clathrin as a novel regulator of ecdysone receptor signaling pathway)
Hirano Masashi, Suzuki Ken-ichi T., Iwata Hisato
環境ホルモン学会研究発表会要旨集   17回 87-87   Dec 2014
天然のダイオキシンである1,3,7-tribromodibenzo-p-dioxinがmysid transcriptomeに及ぼす影響(Effects of a naturally occurring dioxin, 1,3,7-tribromodibenzo-p-dioxin on the mysid transcriptome)
Hirano Masashi, Uchida Masaya, Kusano Teruhiko, Arizono Koji, Iwata Hisato
環境ホルモン学会研究発表会要旨集   17回 86-86   Dec 2014
海棲哺乳類の肝臓におけるHg結合タンパク質
阿草 哲郎, 安木 進也, 池本 徳孝, 國頭 恭, 馬場 徳寿, 田辺 信介, 岩田 久人
Biomedical Research on Trace Elements   25(2) 66-66   Jun 2014
環境発がんと衛生 ヒ素研究の視点から AS3MT遺伝子多型と無機ヒ素のメチル化能力との関係
阿草 哲郎, 國頭 恭, Nguyen Minh Tue, Vi Thi Mai Lan, Tu Binh Minh, Pham Thi Kim Trang, 藤原 純子, 竹下 治男, 高橋 真, Pham Hung Viet, 田辺 信介, 岩田 久人
日本衛生学雑誌   69(Suppl.) S167-S167   May 2014
分析技術の最近の進歩 In silico解析による化学物質と核内受容体・シトクロムP450の相互作用の評価
岩田 久人, 平野 将司, Kim Eun-Young
環境ホルモン学会研究発表会要旨集   16回 31-31   Dec 2013
TCDD曝露したマダイ胚のトランスクリプトーム解析
飯田 緑, 藤井 聡, 内田 雅也, 中村 浩, 鏡 良弘, Bak Su-Min, 金 恩英, 島 康洋, 岩田 久人
環境ホルモン学会研究発表会要旨集   16回 70-70   Dec 2013
ホッキョクグマのシトクロムP4501Aおよび2BによるPCBs代謝能力の評価
古池 幸, 平野 将司, 鈴木 賢一, Jean Yoo, 阿草 哲郎, Evans Thomas J., Kannan Kurunthachalam, 岩田 久人
環境ホルモン学会研究発表会要旨集   16回 148-148   Dec 2013
Ecdysone受容体のリガンド結合とトランス活性化に重要なアミノ酸残基の同定(Identification of amino acid residues critical for ligand binding and transactivation in ecdysone receptor)
Hirano Masashi, Ishibashi Hiroshi, Kim Eun-Young, Arizono Koji, Iwata Hisato
環境ホルモン学会研究発表会要旨集   16回 119-119   Dec 2013
組換え近交系マウスを用いたヒ素感受性遺伝子座の同定
阿草 哲郎, 小森 浩章, 曽我 美子, 宮崎 龍彦, 能勢 眞人, 森 士朗, 久保田 領志, 田辺 信介, 岩田 久人
Biomedical Research on Trace Elements   24(2) 103-103   Jun 2013
組換え近交系マウスにおけるダイオキシン感受性の系統差 AhR非依存的規定因子の探索(2)
岩田 久人, 三浦 良彰, 阿草 哲郎, 能丸 幸治, 渡辺 倫夫, 鈴木 賢一, Cho See-Eun, Kim Eun-Young, 宮崎 龍彦, 能勢 眞人
環境ホルモン学会研究発表会要旨集   15回 140-140   Dec 2012
ダイオキシン様化学物質によるin vitroでの水鳥類AHR1とAHR2のトランス活性化能と野生集団のリスク評価への応用(In vitro transactivation potencies of cormorant AHR1 and AHR2 by dioxin-like chemicals and their application to risk assessment of the wild population)
Iwata Hisato, Thuruthippalil Leena Mol, Kubota Akira, Kim Eun-Young
環境ホルモン学会研究発表会要旨集   15回 54-54   Dec 2012
生態毒性試験生物の基礎研究 鳥類の環境毒性学 AHRシグナル伝達系の特徴とダイオキシン類のリスク評価
岩田 久人, Lee Jin-Seon, Mol Thuruthippallil Leena, 久保田 彰, Kim Eun-Young
The Journal of Toxicological Sciences   37(Suppl.1) S37-S37   Jul 2012
ベトナム人の無機ヒ素メチル化能力とAS3MTのSNPsの関係
阿草 哲郎, 國頭 恭, Nguyen Minh Tue, Vi Thi Mai Lan, Tu Binh Minh, Pham Thi Kim Trang, 藤原 純子, 竹下 治男, 高橋 真, Pham Hung Viet, 田辺 信介, 岩田 久人
Biomedical Research on Trace Elements   23(2) 171-171   Jun 2012
組み換え近交系マウスにおけるダイオキシン感受性の系統差 AhR非依存的規定因子の探索
三浦 良彰, 渡辺 倫夫, 鈴木 賢一, Cho See-Eun, 金 恩英, 宮崎 龍彦, 能勢 眞人, 岩田 久人
環境ホルモン学会研究発表会要旨集   14回 116-116   Dec 2011
Xenopus laevisにおける、アリール炭化水素受容体アゴニスト6-formylindolo[3,2-b]carbazoleに対するパラロガスなCYP1A6遺伝子とCYP1A7遺伝子の異なる調節(Differential regulation of paralogous CYP1A6 and 1A7 genes in response to an aryl hydrocarbon receptor agonist, 6-formylindolo[3,2-b]carbazole, in Xenopus
Suzuki Ken-ichi T., Iwata Hisato
環境ホルモン学会研究発表会要旨集   14回 107-107   Dec 2011
Perfluoroalkyl carboxylatesとperfluoroalkyl sulfonatesの、バイカルアザラシとヒトのペルオキシソーム増殖因子活性化受容体αとの直接結合親和性(Direct binding affinities of perfluoroalkyl carboxylates and sulfonates to the Baikal seal and human peroxisome proliferator-activated receptor α)
Ishibashi Hiroshi, Kim Eun-Young, Iwata Hisato
環境ホルモン学会研究発表会要旨集   14回 48-48   Dec 2011

Books etc

 
Arsenic in Geosphere and Human Diseases : Methylation of inorganic arsenic and genetic polymorphisms in arsenic (+III oxidation state) methyltransferase in a Vietnamese population
CRC Press   2010   
Interdisciplinary Studies on Environmental Chemistry vol. 3, Biological Responses to Contaminants: from Molecular to Community Level : Interindividual variation in arsenic metabolism in a Vietnamese population: association with 17 single nucleotide pol・・・
TERRAPUB   2010   
Interdisciplinary Studies on Environmental Chemistry vol. 3, Biological Responses to Contaminants: from Molecular to Community Level : Interindividual variation in arsenic metabolism in a Vietnamese population: association with 17 single nucleotid...
Interdisciplinary Studies on Environmental Chemistry Vol. 4, Environmental Specimen Bank: Exploring Possibility of Setting-up ESBs in Developing Countries : Cytochrome P450 family 1 genes in Xenopus tropicalis
TERRAPUB   2010   
Interdisciplinary Studies on Environmental Chemistry Vol. 4, Environmental Specimen Bank: Exploring Possibility of Setting-up ESBs in Developing Countries : Toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on peripheral nervous system of dev・・・
TERRAPUB   2010   
Interdisciplinary Studies on Environmental Chemistry Vol. 4, Environmental Specimen Bank: Exploring Possibility of Setting-up ESBs in Developing Countries : Toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on peripheral nervous system o...
Interdisciplinary Studies on Environmental Chemistry Vol. 4, Environmental Specimen Bank: Exploring Possibility of Setting-up ESBs in Developing Countries : Development of an in vitro reporter gene assay for screening the ecdysone receptor agonists in ・・・
TERRAPUB   2010   
Interdisciplinary Studies on Environmental Chemistry Vol. 4, Environmental Specimen Bank: Exploring Possibility of Setting-up ESBs in Developing Countries : Development of an in vitro reporter gene assay for screening the ecdysone receptor agonist...
Interdisciplinary Studies on Environmental Chemistry Vol. 4, Environmental Specimen Bank: Exploring Possibility of Setting-up ESBs in Developing Countries : Molecular characterization of peroxisome proliferator-activated receptor isoforms from the baik・・・
TERRAPUB   2010   
Interdisciplinary Studies on Environmental Chemistry Vol. 4, Environmental Specimen Bank: Exploring Possibility of Setting-up ESBs in Developing Countries : Molecular characterization of peroxisome proliferator-activated receptor isoforms from the...
Interdisciplinary Studies on Environmental Chemistry, Vol. 3, Biological Responses to Chemical Contaminants: From Molecular to Community Level : Risk assessment of dioxins in wild birds by the combination of contamination level and species-specific res・・・
TERRAPUB   2010   
Interdisciplinary Studies on Environmental Chemistry, Vol. 3, Biological Responses to Chemical Contaminants: From Molecular to Community Level : Risk assessment of dioxins in wild birds by the combination of contamination level and species-specifi...
Persistent organic pollutants in Vietnam: environmental contamination and human exposure. Review of Environmental Contamination and Toxicology
Springer   2008   
Ecological Risk Assessment and Regulation of Chemical Substances-Agricultural Chemicals
2006   
Contamination of the ecosystems of Lake Baikal by persistent organochlorines
In: Minoura, K. editor. Lake Baikal; A mirror in time and space for understanding global change processes. The Netherland: Elsevier   2000   

Conference Activities & Talks

 
Effects of exposure to tris (2-chloroethyl) phosphate (TCEP) on chicken embryos: in situ observation in a shell-less incubation system
Kazuki Kanda, Shohei lto, Dong-Hee Koh, Eun-Young Kim, Hisato Iwata
15 Dec 2018   
Implication of obesogenic effects of prenatal bisphenol A exposure on rat offspring by multi-omics analysis
Hoa Thanh Nguyen, Kimika Yamamoto, Midori Iida, Tetsuro Agusa, Mari Ochiai, Lingyun Li, Kurunthachalam Kannan, Eun-Young Kim, Hisato Iwata
15 Dec 2018   
Hepatic proteome profiling in cane toad [rhinella marina] from the Philippines
Rosal, J. J., Tsuchiya, M. C., Agusa, T., Hirano, M., Iwata, H.
SETAC AP 2018   18 Sep 2018   
Characterization of the hepatic transcriptome in chicken AHR2 transgenic mice
Park, J-G., Nomura, K., Iwata, H., Kim, E-Y.
SETAC AP 2018   18 Sep 2018   
Effects of exposure to tris [2-chloroethyl] phosphate [tcep] on chicken embryos in the shell-less incubation system
Kanda, K., Ito, S., Koh, D-H., Kim, E-Y., Iwata, H.
SETAC AP 2018   18 Sep 2018   
Evaluation of sensitivity of dioxin related chemicals to polar bear [ursus maritimus] AHR
Hwang, J-H., Kannan, K., Evans, T. J., Iwata, H., Kim, E-Y.
SETAC AP 2018   18 Sep 2018   
In vitro and in silico ahr assays for assessing the risk of heavy oilcontaminated marine fish
Bak, S. M., Nakata, H., Koh, D-H., Yoo, J., Iwata, H., Kim, E-Y.
SETAC AP 2018   17 Sep 2018   
Differences in POPs and transcriptomes of wild and hatchery-reared baltic salmons
Kanerva, M., Nguyen, M. T., Kunisue, T., Amvuori, K., Iwata, H.
SETAC AP 2018   17 Sep 2018   
Effect of prenatal bisphenol a exposure on the hepatic transcriptome in chicken embryos: understanding of sexspecific effects
Ito, S., Iida, M., Nguyen, H.T., Agusa, T., Hirano, M., Ochiai M., Kim, E-Y., Iwata, H.
SETAC AP 2018   17 Sep 2018   
Structure-activity relationships of Baikal seal estrogen receptors and environmental phenols
Yoshinouchi Y, Hirano M, Nakata H, Nomiyama K, Tanabe S, Kim E-Y, Iwata H
EUROTOX2018   3 Sep 2018   
In vitro cytotoxicity assessments of persistent organic pollutants using cetacean fibroblasts
Ochiai M, Kurihara N, Matsuda A, Nakagun S, Shiozaki A, Nakata A, Matsuishi T, Kunisue T, Iwata H
EUROTOX2018   3 Sep 2018   
PCBs as an environmental obesogen in dogs: evidence from hepatic transcriptome, metabolome, and lipidome analyses
Tamura S, Agusa T, Hirano M, Eguchi A, Nomiyama K, Li L, Kannan K, Tanabe S, Kim EY, Iwata H
Dioxin2018   28 Aug 2018   
In vitro and in silico approaches for assessing the activation of Baikal seal estrogen receptors by bisphenols and OH-PCBs
Yoshinouchi Y, Hirano M, Nakata H, Nomiyama K, Tanabe S, Kim EY, Iwata H
Dioxin2018   28 Aug 2018   
Evaluating estrogenic and anti-estrogenic potency of bisphenol A analogues in vivo and in silico using zebrafish
Kubota A, Wakayama Y, Lee JS, Nakamura M, Kawai Y, Yoshinouchi Y, Iwata H, Hirano M, Nakata H
Dioxin2018   27 Aug 2018   
Develop of in silico computational method for seeking the PPARγ ligand
Koh D-H, Song W-S, Hwang J-H, Iwata H, Kim E-Y
Dioxin2018   Aug 2018   
IN SITU OBSERVATIN OF CHICKEN EMBRYOS TREATED WITH TRIS(2-CHLOROETHYL) PHOSPHATE(TCEP) IN THE SHELL-LESS INCUBATION SYSTEM
Kazuki Kanda, Shohei Ito, Dong-Hee Koh, Eun-Young Kim, Hisato Iwata
20 Jul 2018   
Molecular Mechanisms Underlying Species Differences in Transactivation Potencies of Seal and Dog Estrogen Receptors by OH-PCBs
Yuka Yoshinouchi, Hiroki Okuda, Masashi Hirano, Kei Nomiyama, Shinsuke Tanabe, Kim Eun-Young, Hisato Iwata
SOT 57th Annual Meeting and ToxExpo   15 Mar 2018   
Predicted Adverse Outcome Pathways of Prenatal Exposure to Triclosan in Chicken Embryos
Jiahua Guo, Shohei Ito, Hoa Thanh Nguyen, Kimika Yamamoto, Rumi Tanoue, Tatsuya Kunisue, Hisato Iwata
SOT 57th Annual Meeting and ToxExpo   14 Mar 2018   
In Silico Prediction and In Vivo Measurement of Estrogen-Like Effects of Bisphenol Analogues in Zebrafish
Akira Kubota, Y. Wakayama, M. Nakamura, Y. Kawai, Yuka Yoshinouchi, Hisato Iwata, Masashi Hirano, H. Nakata
SOT 57th Annual Meeting and ToxExpo   13 Mar 2018   
Transcriptome Analysis Reveals the Mechanism of Transgenerational Effects of Bisphenol A in Rats
Hoa Thanh Nguyen, Kimika Yamamoto, Midori Iida, Tatsuya Agusa, Masashi Hirano, Mari Ochiai, Kim Eun-Young, Hisato Iwata
SOT 57th Annual Meeting and ToxExpo   13 Mar 2018   
Hepatic Transcriptome Analysis to Assess the Effects of Prenatal Bisphenol A Exposure on Developing Chicken Embryos
Shohei Ito, Midori Iida, Hoa Thanh Nguye, Tetsuro Agusa, Masashi Hirano, Mari Ochiai, Kim Eun-Young, Hisato Iwata
SOT 57th Annual Meeting and ToxExpo   13 Mar 2018   
Persistent organic pollutants (POPs) in dolphin species -Species- and tissue-specific accumulation-
Ochiai, M., Isobe, T., Tajima, Y., Yamada, T. K., Nomiyama, K., Kunisue, T., Iwata, H., Tanabe, S.
10th International Meeting of Asian Society of Conservation Medicine   Sep 2017   
Transcriptome analysis to assess the effects of prenatal bisphenol A exposure on developing chicken embryos
Ito, S., Iida, M., Nguyen, H. T., Agusa, T., Hirano, M., Ochiai, M., Kim, E. Y., Iwata, H.
The International Symposium on Persistent Toxic Substances (ISPTS2017)   Sep 2017   
Gender and life stage defferences in effects of prenatal exposure to bisphenol A on the liver transcriptome of rat offspring
Nguyen, H. T., Yamamoto, K., Agusa, T., Hirano, M., Ochiai, M., Kim, E. Y., Iwata, H.
The International Symposium on Persistent Toxic Substances (ISPTS2017)   Sep 2017   
Effects on hepatic transcriptome and metabolome in beagle dogs treated with PCBs
Tamura, S., Agusa, T., Hirano, M., Eguchi, A., Nomiyama, K., Tanabe, S., Kim, E. Y., Iwata, H.
The International Symposium on Persistent Toxic Substances (ISPTS2017)   Sep 2017   
Transgenerational effects of bisphenol a on liver transcriptome of rat offspring
Nguyen, H. T., Yamamoto, K., Agusa, T., Hirano, M., Ochiai, M., Kim, E. Y., Iwata, H.
Vietnam – Japan Scientific Exchange Meeting 2017   Sep 2017   
Effects of pops on the lymphocyte proliferation of captive bottlenose dolphins (tursiops truncatus)
Nishida, Y., Ochiai, M., Sawa, S., Iwata, S., Iwata, H.
19th International Symposium on Pollutant Responses in Marine Organisms (PRIMO19)   Jun 2017   
Effects of pcb-exposure on thyroid hormone homeostasis of dogs and cats
Takaguchi, K., Nomiyama, K., Nishikawa, H., Mizukawa, H., Tanoue, R., Yoshinouchi, Y., Yokoyama, N., Ichii, O., Takiguchi, M., Nakayama, S., Ikenaka, Y., Ishizuka, M., Iwata, H., Kunisue, T., Tanabe, S.
19th International Symposium on Pollutant Responses in Marine Organisms (PRIMO19)   Jun 2017   
Identification of cytochrome p450 gene families in the liver transcriptome of baikal seals (pusa sibirica)
Tsuchiya, M. C., Aquino, G. M., Kim, E. Y., Iwata, H.
19th International Symposium on Pollutant Responses in Marine Organisms (PRIMO19)   Jun 2017   
Identification of ahr signaling pathways affected by tcdd exposure in red seabream embryos
Iida, M., Fujii, S., Uchida, M., Nakamura, H., Kagami, Y., Agusa, T., Hirano, M., Bak, S. M., Kim, E. Y., Iwata, H.
19th International Symposium on Pollutant Responses in Marine Organisms (PRIMO19)   Jun 2017   
Liver transcriptome changes by exposure to 4-oh-cb107 in male wistar rats
Iida, M., Ochiai, M., Agusa, T., Fujii, S., Iwata, H.
19th International Symposium on Pollutant Responses in Marine Organisms (PRIMO19)   Jun 2017   
Effects of in vivo exposure to pcbs on hepatic transcriptome and metabolome in beagle dogs
Tamura, S., Agusa, T., Hirano, M., Eguchi, A., Nomiyama, K., Tanabe, S., Kim, E. Y., Iwata, H.
19th International Symposium on Pollutant Responses in Marine Organisms (PRIMO19)   Jun 2017   
Developmental effects of prenatal exposure to bisphenol a on the hepatic transcriptome in chicken embryos
Ito, S., Iida, M., Nguyen, H. T., Agusa, T., Hirano, M., Ochiai, M., Kim, E. Y., Iwata, H.
19th International Symposium on Pollutant Responses in Marine Organisms (PRIMO19)   Jun 2017   
Effects of prenatal exposure to triclosan on the liver transcriptome in chicken embryos
Guo, J., Ito, S., Nguyen, H. T., Iwata, H.
19th International Symposium on Pollutant Responses in Marine Organisms (PRIMO19)   Jun 2017   
Hepatic proteome analysis of nile tilapias from philippines contaminated with pops
Legaspi, B. C. L., Tsuchiya, M. C., Hirano, M., Agusa, T., Matsuoka, J., Kunisue, T., Iwata, H.
19th International Symposium on Pollutant Responses in Marine Organisms (PRIMO19)   Jun 2017   
In silico and in vitro screening of the effects of ppcps on mysid ecdysteroid receptor signaling
Hirano, M., Ohno, Y., Iwata, H.
19th International Symposium on Pollutant Responses in Marine Organisms (PRIMO19)   Jun 2017   
Species differences in transactivation potencies of seal and dog estrogen receptors by hydroxylated pcbs
Yoshinouchi, Y., Okuda, H., Hirano, M., Nomiyama, K., Tanabe, S., Kim, E. Y., Iwata, H.
19th International Symposium on Pollutant Responses in Marine Organisms (PRIMO19)   Jun 2017   
Assessment of heavy oil-derived pahs for red seabream ahr activation by in silico and in vitro approaches
Bak, S. M., Nakata, H., Iwata, H., Kim, E. Y.
19th International Symposium on Pollutant Responses in Marine Organisms (PRIMO19)   Jun 2017   
Molecular structural analysis of specific ligand activity of polar bear (ursus maritimus) ahr
Hwang, J., Kannan, K., Evans, T. J., Iwata, H., Kim, E. Y.
19th International Symposium on Pollutant Responses in Marine Organisms (PRIMO19)   Jun 2017   
In vivo and in silico assessment of estrogen-like effects of bisphenol analogues in zebrafish
Wakayama, Y., Nakamura, M., Morita, Y., Yoshinouchi, Y., Iwata, H., Hirano, M., Nakata, H., Kawai, Y., Kubota, A.
19th International Symposium on Pollutant Responses in Marine Organisms (PRIMO19)   Jun 2017   
Effects of prenatal exposure to bisphenol a on the liver weight and hepatic gene expression in rat offspring
Yamamoto, K., Nguyen, H. T., Agusa, T., Hirano, M., Ochiai, M., Kim, E. Y., Iwata, H.
19th International Symposium on Pollutant Responses in Marine Organisms (PRIMO19)   Jun 2017   
Hepatic transcriptome responses to bisphenol a prenatal exposure in rat offspring
Nguyen, H. T., Yamamoto, K., Agusa, T., Hirano, M., Ochiai, M., Kim, E. Y., Iwata, H.
19th International Symposium on Pollutant Responses in Marine Organisms (PRIMO19)   Jun 2017   
Risk assessment of triclosan in the global environment using a probabilistic approach
Guo, J., Iwata, H.
19th International Symposium on Pollutant Responses in Marine Organisms (PRIMO19)   Jun 2017   
Neurotoxicity assessment of environmental contaminats with chemically-induced neurons of dolphins
Ochiai, M., Nguyen, H. T., Kurihara, N., Hirano, M., Murakami, Y., Iwata, H.
19th International Symposium on Pollutant Responses in Marine Organisms (PRIMO19)   Jun 2017   
Structure-activity relationships of baikal seal estrogen receptors and environmental pollutants
Yoshinouchi, Y., Hirano, M., Nakata, H., Nomiyama, K., Tanabe, S., Kim, E. Y., Iwata, H.
19th International Symposium on Pollutant Responses in Marine Organisms (PRIMO19)   Jun 2017   
Auto-induction mechanism of aryl hydrocarbon receptor 2 gene by tcdd-activated ahr1 and ahr2 in the red seabream
Bak, S. M., Iida, M., Soshilov, A. A., Denison, M. S., Iwata, H., Kim, E. Y.
19th International Symposium on Pollutant Responses in Marine Organisms (PRIMO19)   Jun 2017   
Effects of a naturally synthesized dioxin, 1, 3, 7-tribromodibenzo-p-dioxin on the mysid transcriptome
Hirano, M., Uchida, M., Arizono, K., Iwata, H.
19th International Symposium on Pollutant Responses in Marine Organisms (PRIMO19)   Jun 2017   
In vitro and in silico assessment of cytochrome P450-dependent biotransformation capacity of PCBs in the Caniformia; the Baikal seal vs the beagle dog
Iwata, H., Yoo, J., Tamura, S., Hirano, M., Nomiyama, K., Tanabe, S. and Kim, E. Y.
SETAC North America 37th Annual Meeting   Nov 2016   
Cross omics analysis for PCBs toxicity in the dog brain-Effect on mitochondrial functions-
Takaguchi, K., Nomiyama, K., Lauan, C. M., Yoo, J., Mizukawa, H., Iwata, H., Kunisue, T. and Tanabe, S.
SETAC North America 37th Annual Meeting   Nov 2016   
Sex-dependent effects of prenatal bisphenol A exposure on liver transciptome of rat offspring
Thanh, N. H., Agusa, T., Hirano, M., Ochiai, M., Kim, E.Y. and Iwata, H.
SETAC North America 37th Annual Meeting   Nov 2016   
Next generation sequencing analysis to assess the effects of prenatal bisphenol A exposure on developing chicken embryos
Itoh, S., Agusa, T, Hirano, M., Ochiai, M., Kim, E. Y. and Iwata, H.
SETAC North America 37th Annual Meeting   Nov 2016   
Hepatic proteome to accoun for the molecular mechanism underlying dioxin susceptibility in C2H/Ipr and MRL/Ipr mouse strains
Thanh, N. H., Lauan, M. C., Yoo, J., Iida, M., Agusa, T., Kim, E. Y. and Iwata, H.
SETAC North America 37th Annual Meeting   Nov 2016   
Hepatic transcriptome analysis to assess the effects of polychlorinated biphenyls on beagle dogs
Tamura, S., Agusa, T., Hirano, M., Eguchi, A., Nomiyama, K., Tanabe, S., Kim. E. Y. and Iwata, H.
The 9th International PCB Workshop   Oct 2016   
Risk assessment of disruption of estrogen receptor signaling pathway by OH-PCBs in Baikal seals; application of in vitro and in silico approaches
Yoshinouchi, Y., Hirano, M., Nomiyama, K., Tanabe, S., Kim, E. Y. and Iwata, H.
The 9th International PCB Workshop   Oct 2016   
Disruption of mitochondrial functions by PCB exposure in the dog brain: Toxicological assessment using cross omics
Takaguchi, K., Nomiyama, K., Eguchi, A., Claret, L. M., Kusaki, M., Yoo, J., Mizukawa, H., Iwata, H., Kunisue, T. and Tanabe, S.
The 9th International PCB Workshop   Oct 2016   
Toxicological assessment of PCBs and OH-PCBs in the brain of dogs using metabolomics approach
Nomiyama, K., Takaguchi, K., Eguchi, A., Mizukawa, H., Yoo, J., Tamura, S., Oshihoi, T., Iwata, H., Kunisue, T. and Tanabe, S.
The 9th International PCB Workshop   Oct 2016   
Accumulation prperties of polychlorinted biphenyl cogeners in Yusho patients and assessment of their cytochrome P450-dependent metabolism by in silico docking simulation
Hirakawa S., Miyawaki, T., Hori, T., Kajiwara, J., Susumu, K., Hirano, M., Iwata, H. and Masutaka, F.
The 9th International PCB Workshop   Oct 2016   
Hepatic proteome analysis of dioxin-sensitive and -resistant mice exposed to 2,3,7,8-tetrabromodibenzo-p-dioxin
Thanh, H. N., Lauan, M. C., Yoo, J., Iida, M., Agusa, T., Hirano, M., Kim, E. Y. and Iwata, H
15th Human Proteome Organization World Congress (HUPO 2016 Taipei)   Sep 2016   
Contamination by trace elements associated with e-waste recycling processes in developing countries
3. Agusa, T., Takigami, H., Fujimori, T., Eguchi, A., Bekki, K., Yoshida, A., Terazono, A., Ha, N. N., Asante, K. A., Biney, C. A., Agyekum, W. A., Bello, M., Ramu, K., Ballesteros Jr., F. C., Bulbule, K. A., Parthasaraty, P., Takahashi, S., Subramanian, A., Iwata, H. and Tanabe, S
2016 1st Eastern Asia Conference for Sustainable Economy (EACSE)   Sep 2016   
In vitro and in silico approaches for assessing the activation of Baikal seal estrogen receptors by OH-PCBs
Yoshinouchi, Y, Hirano, M., Nomiyama, K., Tanabe, S., Kim, E. Y. and Iwata, H
36th International Symposium on Halogenated Persistent Organic Pollutants   Aug 2016   
The aryl hydrocarbon receptor signaling pathway in the red seabream
Iwata, H., Bak, S. M., Iida, M. and Kim, E. Y.
6th Joint Forum of Environnmental Sciences   Aug 2016   
Structural preference of OH-PCBs to activate the Baikal Seal estrogen receptors
Yoshinouchi, Y., Hirano, M., Nomiyama, K., Tanabe, S., Kim, E. Y. and Iwata, H.
International Symposium of Environmental Chemistry and toxicology - To Accelerate a Global Network of Environmental Researchers   Mar 2016   
Effects of prenatal exposure to BPA on the growth and organ development in postnatal rats
Yamamoto, K., Hoa, N. T., Agusa, T., Hirano, M., Ochiai, M., Kim, E. Y. and Iwata, H.
International Symposium of Environmental Chemistry and toxicology - To Accelerate a Global Network of Environmental Researchers   Mar 2016   
Assessment of metabolic potential of polyhlorinated biphenyl congeners in the beagle dog liver by in vitro and in silico approaches
Yoo, J., Hirano, M., Nomiyama, K., Kim, E. Y., Tanabe, S. and Iwata, H.
International Symposium of Environmental Chemistry and toxicology - To Accelerate a Global Network of Environmental Researchers   Mar 2016   
Hepatic transcriptome analysis to assess the effects of polychlorinated biphenyls on beagle dogs
Tamura, S., Yoo, J., Mizukawa, H., Agusa, T., Hirano, M., Eguchi A., Nomiyama, K., Tanabe, S., Kim, E. Y. and Iwata, H.
International Symposium of Environmental Chemistry and toxicology - To Accelerate a Global Network of Environmental Researchers   Mar 2016   
Proteomic analysis for PCBs toxicity in the dog brain
Takaguchi, K., Nomiyama, K., Claret, L. M., Kusaki, M., Yoo, J., Mizukawa, H., Iwata, H., Kunisue, T. and Tanabe, S.
International Symposium of Environmental Chemistry and toxicology - To Accelerate a Global Network of Environmental Researchers   Mar 2016   
Influence of lipid compositions on the brain distribution of PCBs and OH-PCBs in triped dolphins
Ochiai, M., Nomiyama, K., Isobe, T., Yamada, T. K., Tajima, Y., Amano, M., Iwata, H. and Tanabe, S.
International Symposium of Environmental Chemistry and toxicology - To Accelerate a Global Network of Environmental Researchers   Mar 2016   
Toxicological assessment of PCBs and Hydroxy-metabolites (OH-PCBs) in the brain of dogs using metabolomics approach
Nomiyama, K., Eguchi, A., Mizukawa, H., Yoo, J., Takaguchi, K., Yamamoto, Y., Oshihoi, T., Iwata, H., Kunisue, T. and Tanabe, S.
International Symposium of Environmental Chemistry and toxicology - To Accelerate a Global Network of Environmental Researchers   Mar 2016   
Effect of prenatal exposure of BPA on the transcriptome in chicken embryos
Itoh, S., Agusa, T., Hirano, M., Ochiai, M., Kim, E. Y. and Iwata, H.
International Symposium of Environmental Chemistry and toxicology - To Accelerate a Global Network of Environmental Researchers   Mar 2016   
Transcriptome analysis to identify adverse outcome pathways mediated by the aryl hydrocarbon receptor in TCDD-treated red seabream embryos
Iida, M., Fujii, S., Uhida, M., Nakamura, H., Kagami, Y., Agusa, T., Hirano, M., Bak, S. M., Kim, E. Y. and Iwata, H.
International Symposium of Environmental Chemistry and toxicology - To Accelerate a Global Network of Environmental Researchers   Mar 2016   
Ecological factors drive natural selection pressure affecting avian dioxin receptor genotypes
Hwang, J. H., Park, J. Y., Park, H. J., Bak, S. M., Hirano, M., Iwata, H., Park, Y. S. and Kim, E. Y.
International Symposium of Environmental Chemistry and toxicology - To Accelerate a Global Network of Environmental Researchers   Mar 2016   
Liver transcriptome analysis to assess the effects of prenatal exposure to bisphenol a of rat offspring
Hoa, T. N., Yamamoto, K., Agusa, T., Hirano, M., Ochiai, M., Kim, E. Y. and Iwata, H.
International Symposium of Environmental Chemistry and toxicology - To Accelerate a Global Network of Environmental Researchers   Mar 2016   
Hirano, M., Uchida, M., Kusano, T., Arizono, K. and Iwata, H.
Effects of a naturally occurring dioxin, 1,3,7-tribromodibenzo-p-dioxin on the mysid transcriptome
International Symposium of Environmental Chemistry and toxicology - To Accelerate a Global Network of Environmental Researchers   Mar 2016   
International Symposium of Environmental Chemistry and toxicology - To Accelerate a Global Network of Environmental Researchers
Lauan, M. C., Yoo, J., Agusa, T., Hirano, M., Kim, E. Y. and Iwata, H.
Assessment of effects of dioxins in the Baikal seal (Pusa Sibirica) by proteome and transcriptome analyses   Mar 2016   
Past, present, and future perspectives of environmental toxicology at Ehime University: advent of an era of the authentic animal study
Iwata, H.
International Symposium of Environmental Chemistry and toxicology - To Accelerate a Global Network of Environmental Researchers   Mar 2016   
Lipid composition in the brain compartments of striped dolphins (Stenella coeruleoalba) in relation to the accumulation of environmental pollutants (PCBs and OH-PCBs)
Ochiai, M., Nomiyama, K., Isobe, T., Yamada, T. K., Tajima, Y., Iwata, H., Amano, M. and Tanabe, S.
21st Biennial Society for Marine Mammalogy Conference on the Biology of Marine Mammals   Dec 2015   
Toxicological assessment of polychlorinated biphenyls and their metabolites in the Baikal seal (Pusa sibirica)
Nomiyama, K., Hirakawa, S., Kanbara, C., Imaeda, D., Yoo, J., Kunisue, T., Kim, E. Y., Iwata, H. and Tanabe, S.
Leading Symposium on Chemical Hazard and Adaptability in Animals – The Current Challenge of Young Researchers   Dec 2015   
Contamination by arsenic and other trace elements in groundwater from the Red and Mekong River Deltas
Agusa, T., Iwata, H., Kunito, T., Inoue, S., Kubota, R., Karri, R., Minh, T. B., Tue, N. M., Ha, N. N., Tu, N. P. C., Charaborty, P., Chamnan, C., Trang, P. T. K., Reungsang, A., Srisuk, K., Nakamura, S., Takizawa, S., Subramanian, A., Tuyen, B. C., Viet, P. H., Tana, T. S. and Tanabe, S.
The Second Myanmar-Japan Symposium   Dec 2015   
Proteome and transcriptome analyses for identification of pathways affected by dioxin accumulation in Baikal seals
Lauan, M. C., Yoo,, J., Agusa, T., Hirano, M. and Iwata, H.
42nd Philippine Society of Biochemistry and Molecular Biology Annual Convention   Dec 2015   
Toxicological assessment of polychlorinated biphenyls (PCBs) and hydroxylated PCBs (OH-PCBs) in the brain of dogs using metabolomics approach
Nomiyama, K., Eguchi, A., Mizukawa, H., Yoo, J., Takaguchi, K., Yamamoto, Y., Oshihoi, T., Iwata, H., Kunisue, T. and Tanabe, S.
Society of Environmental Toxicology and Chemistry (SETAC) North America 36th Annual Meeting   Nov 2015   
Omics approach of proteomic and metabolomics analysis for PCBs toxicity in the dog brain
Takaguchi, K., Nomiyama, K., Lauan, M. C., Yoo, J., Mizukawa, H., Iwata, H., Kunisue, T. and Tanabe, S.
Society of Environmental Toxicology and Chemistry (SETAC) North America 36th Annual Meeting   Nov 2015   
In vitro and in silico assessment of metabolic potential of PCB congeners by cytochrome P450 in the Baikal seal
Yoo. J., Hirano, M., Mizukawa, H., Nomiyama, K., Agusa, T., Kim, E. Y., Tanabe, S. and Iwata, H.
The Korean Society of Environmental health and Toxicology   Oct 2015   
In vitro and in silico assessment of metabolic potential of polychlorinated biphenyls in the beagle dog
Yoo, J., Nomiyama, K., Kim, E. Y., Tanabe, S. and Iwata, H.
The Korean Society of Environmental health and Toxicology   Oct 2015   
Persistent environmental pollutants in Asian coastal waters – contamination of dolphin brains
Ochiai, M., Nomiyama, K., Isobe, T., Yamada, T. K., Tajima, Y., Makara, M., Amano, M., Matsuishi, T., Iwata, H. and Tanabe, S.
Asian Society of Conservation Medicine Meeting   Oct 2015   
Ecological factors affecting natural selection of avian AHR1 genotypes
Hwang J. H., Park, H. J., Bak, S. M., Hirnao, M., Iwata, H., Park, Y. S. and Kim, E. Y.
18th International Symposium on Pollutant Responses in Marine Organisms   May 2015   
In vitro and in silico assessment of transactivation potencies of Baikal seal estrogen receptors
Yoshinouchi, Y., Shimizu, S., Lee, J. S., Hirano, M., Agusa, T., Suzuki, K. T., Nakata, H., Kim, E. Y. and Iwata, H.
18th International Symposium on Pollutant Responses in Marine Organisms   May 2015   
Comparison of hepatic cytochrome P450-dependent metabolic potencies of polychlorinated biphenyls in the caniformia, the Baikal seal and the beagle dog
Yoo, J., Mizukawa, H., Nomiyama, K., Kim, E. Y., Tanabe, S. and Iwata, H.
18th International Symposium on Pollutant Responses in Marine Organisms   May 2015   
Hepatic proteome analysis of Baikal seals contaminated with dioxis and related compounds
Lauan, M. C., Agusa, T., Hirano, M., Iwata, H., Kim, E. Y. and Yoo, J.
18th International Symposium on Pollutant Responses in Marine Organisms   May 2015   
Identification of functional xenobiotic-responsive elements controlling AHR2 expression of red seabream (Pagrus major)
Bak, S. M., Iida, M., Soshilov, A. A., Denison, M. S., Iwata, H. and Kim, E. Y.
18th International Symposium on Pollutant Responses in Marine Organisms   May 2015   
Hepatic cytochrome P450-dependent metabolic potency of polychlorinated biphenyls in the Baikal seal (Pusa sibirica)
Yoo, J., Hirano, M., Mizukawa, H., Nomiyama, K, Agusa, T., Kim, E. Y., Tanabe, S. and Iwata, H.
18th International Symposium on Pollutant Responses in Marine Organisms   May 2015   
The autoinduction mechanism of aryl hydrocarbon receptor 2 (AhR2) through TCDD-activated AhR1/2 in the red seabream (Pusa major)
Bak, S., Kim, E. Y., Iida, M. and Iwata, H.
Society of Toxicology (SOT) 54th Annual Meeting   Mar 2015   
Relationship between mRNA expression level and SNPs of AS3MT in residents from arsenic-contaminated areas in Vietnam
Agusa, T., Kunito, T., Tue, N. M., Lan, V. T., Minh, T. B., Trang, P. T., Fujihara, J., Takeshita, H., Takahashi, S., Viet, P. H., Tanabe, S. and Iwata, H.
Society of Toxicology (SOT) 54th Annual Meeting   Mar 2015   
Strain-differences in the proteome of ioxin-sensitive and –resistant mice treated with 2,3,7,8-tetrabromodibenzo-p-dioxin
Nguyen, T., Lauan, M., Yoo, J., Iida, M., Agusa, T., Kim, E. Y., Miyazaki, T., Nose, M. and Iwata, H.
Society of Toxicology (SOT) 54th Annual Meeting   Mar 2015   
RNA-Seq analysis of the mysid crustacean transcriptome treated with naturally occurring 1,3,7-tribromodibenzo-p-dioxin
Hirano, M., Uchida, M., Kusano, T., Arizono, K. and Iwata, H.
Society of Toxicology (SOT) 54th Annual Meeting, San Diego   Mar 2015   
Toxicological assessment of polychlorinated biphenyls (PCBs) and their metabolites (OH-PCBs) in the liver of wild Baikal seals (Pusa sibirica): Application of microarray and biochemical analysis
Nomiyama, K., Hirakawa, S., Eguchi, A., Kanbara, C., Imaeda, D., Yoo, J., Kunisue, T., Kim, E. Y., Iwata, H. and Tanabe, S.
International Conference of Asian Environmental Chemistry 2014 (ICAEC2014)   Nov 2014   
Isoform specific induction of aryl hydrocarbon receptor by TCDD in the red seabream (Pagrus major)
Bak, S. M., Iida, M., Iwata, H. and Kim, E. Y.
DIOXIN Madrid 2014/34th International Symposium on Halogenated Persistent Organic Pollutants   Sep 2014   
Effects of polychlorinated biphenyls on the expression of cytochrome P450s in beagle dogs
Tamura, S., Yoo, J., Nomiyama, K., Mizukawa, H., Tanabe, S., Agusa, T., Kim, E. Y., Hirano, M. and Iwata, H.
DIOXIN Madrid 2014/34th International Symposium on Halogenated Persistent Organic Pollutants   Sep 2014   
In vitro and in silico assessment of transactivation potencies of Baikal seal estrogen receptors α and β by persistent organic pollutants and bisphenols
Yoshinouchi, Y., Shimizu, S., Suzuki, K., Lee, J. S., Nakata, H., Hirano, M., Kim, E. Y., Agusa, T. and Iwata, H.
DIOXIN Madrid 2014/34th International Symposium on Halogenated Persistent Organic Pollutants   Sep 2014   
Ecological factors as pressure of natural selection of AhR genotypes in avian species
Hwang, J. H., Park, H. J., Park, J. Y., Bak, S. M., Park, Y. S., Hirano, M.., Kim, E. Y. and Iwata, H.
DIOXIN Madrid 2014/34th International Symposium on Halogenated Persistent Organic Pollutants   Sep 2014   
Proteomic analysis of liver microsomes in X. tropicalis
Suzuki, K. I., Nakano, M., Watabe, M., Fukuta, Y. and Iwata, H.
The 12th Human Proteome Organisation World Congress   Sep 2013   

Research Grants & Projects

 
Chemical Contamination in Mekong Delta and Their Toxic Effects on Higher Trophic Animals and Human
Project Year: 2003 - 2006
Ecotoxicogenomics and proteomics in wildlife
SCF System for Establishment and Support of Center's of Excellence
Project Year: 2002 - 2006
Toxic impacts of environmental contaminants in ecosystem
SCF System for Establishment and Support of Center's of Excellence
Project Year: 2002 - 2006
Understanding of molecular mechanisms responsible for species-specific sensitivity of chemical toxicity
Grant-in-Aid for Scientific Research
Project Year: 2001 - 2004
Global distribution,dynamics and fate of persistent organochlorines

Social Contribution

 
19th International Symposium on Pollutant Responses in Marine Organisms (PRIMO19)
[Planner, Organizing Member]  30 Jun 2017 - 3 Jul 2017
International Symposium on Environmental Chemistry and Toxicology - To Accelerate a Global Network of Environmental Researchers
[Planner, Organizing Member]  19 Mar 2016 - 19 Mar 2016