北浦廣剛 (Hirotake Kitaura) - マイポータル - researchmap

基本情報

所属: 北海道医療大学薬学部生命物理科学講座放射薬品化学准教授

学位: 博士（薬学）(東京大学)
薬学修士(東京大学)

通称等の別名: 北浦広剛
J-GLOBAL ID: 200901005859293832
researchmap会員ID: 1000200165

外部リンク

研究キーワード

1

癌遺伝子

経歴

2

2016年4月 - 現在

北海道医療大学, 薬学部生命物理科学講座放射薬品化学, 准教授
1996年

- 北海道大学大学院薬学研究院助教

学歴

6

委員歴

1

2005年 - 2006年

日本薬学会, 日本薬学会誌ファルマシアトピックス専門小委員

MISC

15

Prefoldin Subunits Are Protected from Ubiquitin-Proteasome System-mediated Degradation by Forming Complex with Other Constituent Subunits

Makoto Miyazawa, Erika Tashiro, Hirotake Kitaura, Hiroshi Maita, Hiroo Suto, Sanae M. M. Iguchi-Ariga, Hiroyoshi Ariga

JOURNAL OF BIOLOGICAL CHEMISTRY 286(22) 19191-19203 2011年6月
DJ-1, an oncogene and causative gene for familial Parkinson’s disease, is essential for SV40 transformation in mouse fibroblasts through up- regulation of c-Myc.

KIM Yun Chul, KITAURA Hirotake, IGUCHI-ARIGA Sanae M.M, ARIGA Hiroyoshi

FEBS Lett. 584(18) 3891-3895 2010年9月
Oxidation of DJ-1-dependent cell transformation through direct binding of DJ-1 to PTEN

Yun-Chul Kim, Hirotake Kitaura, Takahiro Taira, Sanae M. M. Iguchi-Ariga, Hiroyoshi Ariga

INTERNATIONAL JOURNAL OF ONCOLOGY 35(6) 1331-1341 2009年12月
Negative regulation of the Wnt signal by MM-1 through inhibiting expression of the wnt4 gene

Tatsuya Yoshida, Hirotake Kitaura, Yuko Hagio, Toshiya Sato, Sanae M. M. Iguchi-Ariya, Hiroyoshi Ariga

EXPERIMENTAL CELL RESEARCH 314(6) 1217-1228 2008年4月
Maita, H., Kitaura, H., Ariga, H. and Iguchi-Ariga, S.M.M. (2005) Association of PAP-1 and Prp3p, the products of causative genes of dominant retinitis pigmentosa, in the tri-snRNP complex. Exp Cell Res. 302, 61-68*

2005年
Maita, H., Kitaura, H., Ariga, H. and Iguchi-Ariga, S.M.M. (2005) CIR, a corepressor of CBF1, binds to PAP-1 and effects alternative splicing. Exp Cell Res. 303, 375-387.*

2005年
Kuroda, T.S., Maita, H., Tabata, T., Taira, T., Kitaura, H., Ariga, H. and Iguchi-Ariga, S.M.M. (2004) A novel nucleolar protein, PAPA-1, induces growth arrest as a result of cell cycle arrest at the G1 phase. Gene 340, 83-98*

2004年
Maita, H., Kitaura, H., Keen, T.J., Inglehearn, C.F., Ariga, H. and Iguchi-Ariga, S.M.M. (2004) PAP-1, the mutated gene underlying the RP9 form of dominant Retinitis pigmentosa, is a splicing factor. Exp Cell Res. 300, 283-296*

2004年
Ono,T.,Kitaura,H.,Ugai,H.,Murata,T.,Yokoyama,K.K.,Iguchi-Ariga,S.M.M. and Ariga,H.: TOK-1, a novel p21Cip1-binding protein that cooperatively enhances p21-dependent inhibitory activity toward CDK2 kinase. J.Biol.Chem. 275,31145-31154(2000)*

2000年
Kitaura,H.,Shinshi,M.,Uchikoshi,Y.,Ono,T.,Iguchi-Ariga,S.M.M. and Ariga,H.: Reciprocal regulation via protein-protein interaction between c-Myc and p21cip1/waf1/sdi1 in DNA replication and transcription. J.Biol.Chem.275,10477-10483(2000)*

2000年
Maita,H.,Harada,Y.,Nagakubo,D.,Kitaura,H.,Ikeda,M.,Tamai,K.,Takahashi,K.,Ariga,H. and Iguchi-Ariga,S.M.M.: PAP-1, a novel target protein of phosphorylation by Pim-1 kinase. Eur.J.Biochem.267,5168-5178(2000)*

2000年
Chida,K. and Kitaura,H.: Nuclear microinjection of EDTA inhibits transient expression of the lac-Z gene and stable transformation by the neomycin-resistant gene in NRK cells possibly by causing disruption of nuclear pore function. Tiss. Cult. Res. Comm・・・

1999年
Mori, K., Maeda, Y., Kitaura, H., Taira, T., Iguchi-Ariga, SM. and Ariga, H. : MM-1, a novel c-Myc-associating protein that represses transcriptional activity of c-Myc. J. Bio. Chem. 273, 29794-29800 (1998)

1998年
Taira, T., Maeda, J., Ohnishi, T., Kitaura, H., Yoshida, S., Kato, H., Ikeda, M., Tamai, K., Iguchi-Ariga, SM. and Ariga, H. : AMY-1, a novel C-MYC binding protein that stimulates transcription activity of C-MYC. Genes to Cells. 3, 549-565 (1998)

1998年
Nagakubo, D., Taira, T., Kitaura, H., Ikeda, M., Tamai, K., Iguchi-Ariga, S. M. M. and Ariga, H. : "DJ-1, a novel oncogene product which transforms mouse NIH3T3 cells in cooperation with H-ras", Biochem. Biophys. Res. Comm., 231 : 509-513 (1997)＊

1997年

所属学協会

5

共同研究・競争的資金等の研究課題

1

細胞増殖におけるc-myc, p21, TOK-1の機能