MISC

2008年5月

Cytomorphologic and immunocytochemical characteristics of reactive renal tubular cells in renal glomerular disease

ACTA CYTOLOGICA
  • Hiroyuki Ohsaki
  • ,
  • Reiji Haba
  • ,
  • Toru Matsunaga
  • ,
  • Muneo Nakamura
  • ,
  • Hideyasu Kiyomoto
  • ,
  • Eiichiro Hirakawa

52
3
開始ページ
297
終了ページ
303
記述言語
英語
掲載種別
出版者・発行元
SCI PRINTERS & PUBL INC

Objective
To investigate the morphologic characteristics and immuno-cytochemical reaction to vimentin of the reactive renal tubular cells (RRTCs) in renal glomerular disease. Study Design
We prospectively evaluated the urine cytology of renal glomerular disease in 40 patients who underwent renal biopy. The cytology and renal biopsy specimens were analyzed for vimentin immunostaining.
Results
A total of 40 urine samples from the 40 patients were cytologically analyzed, and RRTCs were found in 25 samples (25 of 40, 62.5%). These RRTCs showed clear or vacuolated cytoplasm., intracytoplasmic pigmented granules (hemosiderin or lipofuscin) and large nuclei with round to irregular nuclear contours and prominent nucleoli. These cells were seen singly and in acinar clusters. Occasionally RRTCs were embedded in a cast (RRTC cast). Immunocyto chemical study revealed RRTCs to be positive for vimentin (25 of 25, 100%).
Conclusion
Frequently observed characteristic cytomorphologic features of RRTCs included RRTC cast, acinar cluster, vacuolated cytoplasm and intracytoplasmic pigmented granules. A diagnosis of RRTCs can be suggested based on these cytomorphologic features. However, a definitive diagnosis will require immunocytochemical confirmation for vimentin.

Web of Science ® 被引用回数 : 9

リンク情報
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000255970800005&DestApp=WOS_CPL
ID情報
  • ISSN : 0001-5547
  • Web of Science ID : WOS:000255970800005

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