論文

査読有り
2015年7月

Claudin-1, but not claudin-4, exhibits differential expression patterns between well- to moderately-differentiated and poorly-differentiated gastric adenocarcinoma

ONCOLOGY LETTERS
  • Yasunori Tokuhara
  • ,
  • Tatsuya Morinishi
  • ,
  • Toru Matsunaga
  • ,
  • Hiroyuki Ohsaki
  • ,
  • Yoshio Kushida
  • ,
  • Reiji Haba
  • ,
  • Eiichiro Hirakawa

10
1
開始ページ
93
終了ページ
98
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3892/ol.2015.3208
出版者・発行元
SPANDIDOS PUBL LTD

Claudins are members of a large family of transmembrane proteins, which are essential in the formation of tight junctions and have previously been associated with the process of tumor progression. Studies have reported the aberrant expression of claudin-1 and claudin-4 in numerous types of cancer. The present study aimed to investigate the expression of claudin-1 and claudin-4 in gastric adenocarcinoma tissue. Surgically resected gastric adenocarcinoma tissue specimens were obtained from 94 patients. Protein expression levels of claudin-1 and claudin-4 were determined using immunohistochemical staining; the association between claudin-1 or claudin-4 expression and various clinicopathological parameters were then analyzed. In gastric adenocarcinoma specimens, the expression rates of claudin-1 and claudin-4 were 43.6 and 87.2%, respectively. Claudin-1 expression demonstrated a significant correlation with histological type (P<0.01) and was significantly higher in well- to moderately-differentiated gastric adenocarcinomas compared with poorly-differentiated tumors. However, no correlation was observed between claudin-4 expression in adenocarcinoma and clinicopathological parameters. In conclusion, downregulation of claudin-1 expression in poorly-differentiated gastric adenocarcinoma may be involved in the biological transformation of tumors. The present findings suggested that claudin-1 may be an important protein associated with histological type and therefore may have potential for use as a prognostic marker for gastric adenocarcinoma. Further studies are required to elucidate the precise mechanism of claudin expression and its involvement in tumor progression.

Web of Science ® 被引用回数 : 9

リンク情報
DOI
https://doi.org/10.3892/ol.2015.3208
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/26170982
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000358133800015&DestApp=WOS_CPL
ID情報
  • DOI : 10.3892/ol.2015.3208
  • ISSN : 1792-1074
  • eISSN : 1792-1082
  • PubMed ID : 26170982
  • Web of Science ID : WOS:000358133800015

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