論文

査読有り
2014年4月

Oral Administration of Eicosapentaenoic Acid or Docosahexaenoic Acid Modifies Cardiac Function and Ameliorates Congestive Heart Failure in Male Rats

JOURNAL OF NUTRITION
  • Tomoko T. Yamanushi
  • ,
  • Hideaki Kabuto
  • ,
  • Eiichiro Hirakawa
  • ,
  • Najma Janjua
  • ,
  • Fusako Takayama
  • ,
  • Mitsumasa Mankura

144
4
開始ページ
467
終了ページ
474
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3945/jn.133.175125
出版者・発行元
AMER SOC NUTRITION-ASN

This study assessed the effects of eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA) on normal cardiac function (part 1) and congestive heart failure (CHF) (part 2) through electrocardiogram analysis and determination of EPA, DHA, and arachidonic acid (AA) concentrations in rat hearts. In part 2, pathologic assessments were also performed. For part 1 of this study, 4-wk-old male rats were divided into a control group and 2 experimental groups. The rats daily were orally administered (1 g/kg body weight) saline, EPA ethyl ester (EPA-Et; E group), or DHA ethyl ester (DHA-Et; D group), respectively, for 28 d. ECGs revealed that QT intervals were significantly shorter for groups E and D compared with the control group (P <= 0.05). Relative to the control group, the concentration of EPA was higher in the E group and concentrations of EPA and DHA were higher in the D group, although AA concentrations were lower (P <= 0.05). In part 2, CHF was produced by subcutaneous injection of monocrotaline into 5-wk-old rats. At 3 d before monocrotaline injection, rats were administered either saline, EPA-Et, or DHA-Et as mentioned above and then killed at 21 d. The study groups were as follows: normal + saline (control), CHF + saline (H group), CHF + EPA-Et (HE group), and CHF + DHA-Et (HD group). QT intervals were significantly shorter (P <= 0.05) in the control and HD groups compared with the H and HE groups. Relative to the H group, concentrations of EPA were higher in the HE group and those of DHA were higher in the control and HD groups (P <= 0.05). There was less mononuclear cell infiltration in the myocytes of the HD group than in the H group (P = 0.06). The right ventricles in the H, HE, and HD groups showed significantly increased weights (P <= 0.05) compared with controls. The administration of EPA-Et or DHA-Et may affect cardiac function by modification of heart fatty acid composition, and the administration of DHA-Et may ameliorate CHF.

Web of Science ® 被引用回数 : 7

リンク情報
DOI
https://doi.org/10.3945/jn.133.175125
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/24523492
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000333661200009&DestApp=WOS_CPL
ID情報
  • DOI : 10.3945/jn.133.175125
  • ISSN : 0022-3166
  • eISSN : 1541-6100
  • PubMed ID : 24523492
  • Web of Science ID : WOS:000333661200009

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