Hiroshi Kinoshita

Profile Information

Affiliation: Professor, Faculty of Medicine, Kagawa University

Degree: Doctor(Medicine)(*Kagawa Medical University*)

J-GLOBAL ID: 200901064196441600
researchmap Member ID: 1000200380

Research Interests

Research Areas

Life sciences / Forensic medicine /

Research History

Education

- 1996

Kagawa Medical University
- 1992

Kagawa Medical University

Awards

2003

Award for Encouragement of Study from the Japanese society of Legal Medicine.

Papers

151

COA-Cl Evokes Protective Responses Against H2O2-and 6-OHDA-Induced Toxic Injury in PC12 Cells.

Mostofa Jamal, Ikuko Tsukamoto, Takata Maki, Sella Takei, Ryoji Konishi, Hiroshi Kinoshita

Neurotoxicity research, 40(6) 2061-2071, Dec, 2022
Ethanol concentration induces production of 3,4-dihydroxyphenylacetic acid and homovanillic acid in mouse brain through activation of monoamine oxidase pathway.

Mostofa Jamal, Asuka Ito, Takanori Miki, Shingo Suzuki, Ken-Ichi Ohta, Hiroshi Kinoshita

Neuroscience letters, 782 136689-136689, Jun 21, 2022
Fatal poisoning case involving drug interaction due to the inhibition of cytochrome P450.

Kinoshita H, Tanaka N, Kumihashi M, Jamal M, Ito A, Yamashita T, Ameno K

Vojnosanit Pregl, 78(00) 563-566, May, 2021 Peer-reviewedLead author
Dietary iso-α-acids prevent acetaldehyde-induced liver injury through Nrf2-mediated gene expression

Takahito Takase, Tsudoi Toyoda, Naoyuki Kobayashi, Takashi Inoue, Tomoko Ishijima, Keiko Abe, Hiroshi Kinoshita, Youichi Tsuchiya, Shinji Okada

PLOS ONE, 16(2) e0246327-e0246327, Feb 5, 2021 Peer-reviewed
多剤服用による中毒死の一例

木下博之, 田中直子, モストファ・ジャーマル, 伊藤明日香, 山下忠義, 木村正司, 飴野清

日本法医学雑誌, 74(2) 153-154, Dec, 2020
Identification of foreign body using energy-dispertive X-ray fluorescence spectrometry.

Kinoshita H, Tanaka N, Jamal M, Yamashita T, Kimura S

New Bulletin of Medical Sciences, 4(3) 3-6, Dec, 2020 Peer-reviewedLead authorCorresponding author
Identification of a flammable substance in a fire related death.

Kinoshita H, Tanaka N, Jamal M, Ito A, Nagata K, Kumihashi M, Tsutsui K, Kimura S

Rom J Leg Med., 28(4) 403-405, Dec, 2020 Peer-reviewedLead authorCorresponding author
An autopsy case of heatstroke under the influence of psychotropic drugs.

Kinoshita H, Tanaka N, Kumihashi M, Jamal M, Ito A, Nagata K, Tsutsui K, Kimura S

Soud Lek., 65(4) 76-78, Nov, 2020 Peer-reviewedLead author
Detection of helium in a fire victim: a case report.

Soejima M, Tanaka N, Oshima T, Kinoshita H, Koda Y

Forensic Sci Int., 318 110613-110613, Nov, 2020 Peer-reviewed
Appropriate samples for helium detection in postmortem investigations

Hiroshi Kinoshita, Naoko Tanaka, Ayaka Yasumoto-Takakura, Hiroko Abe, Kyoko Maebashi, Akio Tsuboi, Hirotaro Iwase, Kimiharu Iwadate, Motoki Osawa, Osamu Kitamura

Legal Medicine, 47 101784-101784, Nov, 2020 Peer-reviewedLead author
Determination of metallization with energy-dispersive X-ray fluorescent spectrometry in experimental electric injury

Naoko Tanaka, Hiroshi Kinoshita, Mostofa Jamal, Asuka Ito, Tadayoshi Yamashita, Ken Nagata, Nobuyuki Miyatake

Legal Medicine, 47 101768-101768, Nov, 2020 Peer-reviewed
EPN服用の1剖検例

田中直子, 木下博之, モストファ・ジャーマル, 伊藤明日香, 山下忠義, 木村正司, 飴野清

日本法医学雑誌, 74(1) 68-68, Aug, 2020
介護用品による窒息の2症例

伊藤明日香, 田中直子, モストファ・ジャーマル, 山下忠義, 飴野清, 木村正司, 木下博之

日本法医学雑誌, 74(1) 83-83, Aug, 2020
Application of elemental analysis by energy dispersive X-ray fluorescence spectrometry (EDX) to dental restorations: improved sampling using a steel bur and cotton swab.

Yamashita H, Tanaka N, Ikematsu K, Kinoshita H

New Bulletin of Medical Sciences, 4(2) 3-6, Aug, 2020 Peer-reviewedLast authorCorresponding author
Toxicological examination of stomach contents -Utility in clarifying the situation at time of death-.

Tsutsui K, Kinoshita H, Tanaka N, Jamal M, Ito A

Albanian Journal of Medical and Health Sciences., 53 1-4, Jun, 2020 Peer-reviewedCorresponding author
Toxicological analysis of acetone in a forensic case for the diagnosis of fulminant type I diabetes mellitus.

Ito A, Kinoshita H, Jamal M, Tanaka N, Yamashita T, Ameno K

Bangladesh Journal of Medical Science, 19(3) 414-419, Jun, 2020 Peer-reviewed
High ethanol and acetaldehyde decrease extracellular glutamate in the frontal cortex of freely moving mice.

Jamal M, Ito A, Tanaka N, Ameno K, Kinoshita H

Neuroreport, Apr, 2020 Peer-reviewedLast author
メチダチオン服用の1剖検例

田中直子, 木下博之, モストファ・ジャーマル, 伊藤明日香, 山下忠義, 組橋充, 飴野清

中毒研究, 33(1) 105-106, Mar, 2020
Death caused by ethanol and diazepam in a patient with liver cirrhosis.

Kinoshita H, Tanaka N, Kumihashi M, Jamal M, Ito A, Yamashita T, Ozawa Y, Tsutsui K, Kimura S, Kimura Y, Ameno K

Albanian Journal of Medical and Health Sciences., 52(1) 1-5, Mar, 2020 Peer-reviewedLead author
High Ethanol and Acetaldehyde Inhibit Glutamatergic Transmission in the Hippocampus of Aldh2-Knockout and C57BL/6N Mice: an In Vivo and Ex Vivo Analysis.

Mostofa Jamal, Asuka Ito, Naoko Tanaka, Takanori Miki, Kiyoshi Ameno, Hiroshi Kinoshita

Neurotoxicity research, 37(3) 702-713, Feb 15, 2020 Peer-reviewed

Misc.

349

気道内異物の2例

田中直子, 槇野陽介, ジャーマルモストファ, 伊藤明日香, 山下忠義, 永田健, 岩瀬博太郎, 木下博之

法医病理, 26(2) 103-108, Dec, 2020 Peer-reviewedLast author
ティラナ大学法医学研究所

木下博之, 田中直子

法医病理, 26(1) 27-27, Jul, 2020 Peer-reviewedLead author
溺死事例における蝶形骨洞内貯留液量

Forensic Pathology, 26(1) 15-19, Jul, 2020 Peer-reviewedLast author
いわゆる「黒色食道」（急性壊死性食道炎）

木下博之, 田中直子, 組橋充, ジャーマルモストファ, 伊藤明日香, 山下忠義, 木村正司, 木村泰彦, 筒井邦彦, 羽場礼次, 飴野清

法医病理, 25(2) 113-114, Jan, 2020 Peer-reviewedLead authorCorresponding author
青酸中毒

田中直子, 木下博之, 組橋充, 芝山貴幸, ジャーマルモストファ, 伊藤明日香, 山下忠義, 木村正司, 木村泰彦, 筒井邦彦, 飴野清

法医病理, 25(2) 111-112, Jan, 2020 Peer-reviewed
一酸化炭素中毒

木下博之, 田中直子, モストファ・ジャーマル, 伊藤明日香, 山下忠義, 飴野清

法医病理, 25(1) 13-20, Jul, 2019
法医解剖事例における副脾の出現頻度

小澤雄真, 田中直子, モストファ・ジャーマル, 伊藤明日香, 宮武伸行, 山下忠義, 飴野清, 木下博之

法医病理, 25(1) 33-34, Jul, 2019
アセトアルデヒド投与によりマウス線条体において誘発されるsalsolinol形成(Acetaldehyde administration induces salsolinol formation in the striatum of mice)

伊藤明日香, モストファ・ジャーマル, 飴野清, 田中直子, 山下忠義, 小澤雄真, 木下博之

日本法医学雑誌, 73(1) 62-62, May, 2019
Aldh2遺伝子KOマウスへのIP投与後のエタノールとアセトアルデヒド濃度血液と脳に関する考察(Ethanol and acetaldehyde after IP administration to Aldh2-KO mice- reflection in blood and brain)

モストファ・ジャーマル, 伊藤明日香, 田中直子, 飴野清, 木下博之

日本法医学雑誌, 73(1) 90-90, May, 2019
蛍光X線分析法を用いた感電時の皮膚への金属付着の検討(第2報)

田中直子, モストファ・ジャーマル, 伊藤明日香, 小澤雄真, 山下忠義, 木村正司, 飴野清, 木下博之

日本法医学雑誌, 73(1) 108-108, May, 2019
高濃度のスボレキサントが検出された1剖検例

田中直子, モストファ・ジャーマル, 伊藤明日香, 山下忠義, 小澤雄真, 組橋充, 飴野清, 木下博之

中毒研究, 32(1) 98-98, Mar, 2019
新規アデノシンアナログCOA-C1のドパミン分泌促進作用

塚本郁子, Jamal Mostofa, 高田麻紀, 伊藤明日香, 窪田泰夫, 木下博之, 榊原紀和, 小西良士

日本薬学会年会要旨集, 139年会(2) 98-98, Mar, 2019
死後CTで窒息の原因となったゆで卵を確認しえた1例

遠迫俊哉, 安賀文俊, 井原あゆ美, 高見康景, 室田真希子, 木村成秀, 西山佳宏, 田中直子, 高倉彩華, 伊藤明日香, モストファ・ジャーマル, 木下博之

Japanese Journal of Radiology, 37(Suppl.) 55-55, Feb, 2019
形成外科におけるバイオメカニクス研究の、法医学領域における応用経験

工藤博雄, 永竿智久, 畑野麻子, 田中直子, 木下博之

日本形成外科学会会誌, 39(2) 52-57, Feb, 2019
法医解剖における中毒統計調査に向けた薬物分析連携プロジェクト(DSMS:Drug Screening Method Sharing Project)の紹介

前橋恭子, 安部寛子, 奥田勝博, 船越丈司, 則竹香菜子, 田中直子, 高倉彩華, 佐々木千寿子, 林徳多郎, 那須亜矢子, 岩瀬博太郎, 清水惠子, 上村公一, 木下博之, 佐藤文子, 浅村英樹, 井濱容子, 岩楯公晴

日本法医学雑誌, 72(2) 309-309, Dec, 2018
浴槽内死亡機序に関する発見時姿勢および心臓血液量からのアプローチ

長崎靖, 上野易弘, 羽竹勝彦, 主田英之, 近藤武史, 木下博之, 高橋玄倫, 西村明儒, 粕田承吾, 杉村朋子

日本法医学雑誌, 72(2) 312-313, Dec, 2018
気道内異物の1剖検例

田中直子, 高倉彩華, 槇野陽介, モストファ・ジャーマル, 伊藤明日香, 木村正司, 加茂和博, 飴野清, 岩瀬博太郎, 木下博之

日本法医学雑誌, 72(2) 315-315, Dec, 2018
覚せい剤検査における胆汁の有用性

木下博之, 田中直子, 高倉彩華, 組橋充, モストファ・ジャーマル, 伊藤明日香, 木村正司, 加茂和博, 飴野清

日本法医学雑誌, 72(2) 320-321, Dec, 2018
薬物分析連携プロジェクトの取組みと今後の課題

那須亜矢子, 安部寛子, 前橋恭子, 奥田勝博, 船越丈司, 則竹香菜子, 田中直子, 高倉彩華, 佐々木千寿子, 林徳多郎, 岩瀬博太郎, 岩楯公晴, 清水惠子, 上村公一, 木下博之, 佐藤文子, 浅村英樹, 井濱容子

日本法医学雑誌, 72(2) 332-332, Dec, 2018
東京都における火災件数、死亡者数、負傷者数の月別比較および気温、湿度との関連

宮武伸行, 田中直子, 鈴木裕美, 木下博之

地域環境保健福祉研究, 21(1) 11-14, Dec, 2018

Major Books and Other Publications

死体検案ハンドブック

近藤, 稔和, 木下, 博之

金芳堂, Mar, 2020 (ISBN: 9784765318235)
Gas chromatography

Hiroshi Kinoshita, Naoko Tanaka, Jamal Mostofa, Asuka Ito, Mitsuru Kumihashi, Tadayoshi Yamashita, Shoji Kimura, Yasuhiko Kimura, Kunihiko Tsutsui, Shuji Matsubara, Kiyoshi Ameno (Role: Joint author, Application of sensor gas chromatography in forensic medicine.)

Nova Science Publishers, 2020
A closer look at autopsies

Hiroshi Kinoshita, Naoko Tanaka, Mostofa Jamal, Asuka Ito, Mitsuru Kumihashi, Tadayoshi Yamashita, Shoji Kimura, Yasuhiko Kimura, Kunihiko Tsutsui, Kiyoshi Ameno (Role: Joint author, On-site testing at forensic autopsy)

Nova Science Publishers, 2020
Post mortem examination and autopsy. current issues from death to laboratory analysis

KINOSHITA Hiroshi (Role: Joint author, Application of CO-oximeter for forensic samples)

Intech Open, 2018 (ISBN: 9789535137924)
A guide to helium.

KINOSHITA Hiroshi (Role: Joint author, An analysis of helium for postmortem biological samples.)

Nova Science Publishers, 2018 (ISBN: 9781536131642)
Poisonig. from specific toxic agents to novel rapid and simplified techniques for analysis

KINOSHITA Hiroshi (Role: Joint author, Simplified analysis of toxic gaseous substances in forensic practice: experiences from Japan.)

InTech, 2017 (ISBN: 9789535136811)
Gas chromatography. analysis, methods and practices

KINOSHITA Hiroshi (Role: Joint author, Sampling of the postmortem specimen for the analysis of volatile or gaseous substances in forensic practice.)

Nova Science Publishers, 2017 (ISBN: 9781536119909)
犯罪捜査科学 : 捜査・取調・法医・虚偽自白・無罪判決の考証

菱田繁, 山村武彦, 木下博之

金剛出版, 2017 (ISBN: 9784772415699)
Forensic medicine. fundamentals, clinical perspectives and challenges

KINOSHITA Hiroshi (Role: Joint author, Diagnostic application of energy dispersive X-ray fluorescent spectrometry (EDX) in forensic medicine)

Nova Science Publishers, 2016 (ISBN: 9781634852838)
Drug overdoses and alcohol withdrawal

KINOSHITA Hiroshi (Role: Joint author, Toxicological evaluation of psychotropic drug overdose in forensic practice.)

Nova Publishers, 2016 (ISBN: 9781634838733)
Asphyxia Risk Factors, Prevalence and Neurological Impacts

Nova Science Publishers, Inc., 2015 (ISBN: 9781634822251)
Carbon Monoxide Sources, Uses and Hazards

Nova Science Publishers, Inc., 2012 (ISBN: 9781619420557)
集中講義医事法学・法医学

メジカルビュー, 2012 (ISBN: 9784758300896)

Professional Memberships

Research Projects

Establishment of simultaneous analysis method for inorganic compounds and its forensic application

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2024

Hiroshi Kinoshita
メトヘモグロビン血症の原因分析とその病態解析

科学研究費助成事業基盤研究(C), 日本学術振興会, Apr, 2018 - Mar, 2021

木下博之, 田中直子
Forensic pathophysiological study of hydrogen sulfide poisoning.

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

Hiroshi Kinoshita
Role of tissue heme protein on the toxicokinetics of carbon monoxide.

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2015

KINOSHITA HIROSHI, AMENO Kiyoshi, TANAKA Naoko
Neurotrophic factors and cognitive function after alcohol intoxication in mice model

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2010 - 2012

JAMAL Mostofa
Effects of patho-physiological changes on the toxicokinetics of drug and chemicals.

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2009 - 2011

KINOSHITA Hiroshi, AMENO Kiyoshi, TAKAHASHI Motonori
Is there some acetaldehyde formation in the brain?

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2008 - 2010

AMENO Kiyoshi, KINOSHITA Hiroshi, JAMAL Mostofa, UEKITA Ikuo, IJIRI Iwao
Effects of Glucocorticoid on the hyperthermia following methamphetamine administration.

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (A), Japan Society for the Promotion of Science, 2003 - 2004
Effects of combined administration of alcohol and abused drugs (methamphetamine, cocaine) on the central nervous system

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2001 - 2002

HISHIDA Shigeru, KINOSHITA Hiroshi
Effects of ethanol and acetaldehyde on neuropeptide Y expression in brain.

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2001 - 2002
Effect of acetaldehyde on neurotransmitter in the rat brain

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2000 - 2002

IJIRI iwao, HISHIDA shigeru, OKADA naoko, AMENO kiyoshi
Study on Mechanism of Ethanol Prefernce

2001
Effects of ethanol and acetaldehyde on 5-HT receptor expression in brain.

Grants-in-Aid for Scientific Research Grant-in-Aid for Encouragement of Young Scientists (A), Japan Society for the Promotion of Science, 1999 - 2000
Effects of Ethanol on the neuroendocrine system.

Daiwa Anglo Japanese Foundation, Apr, 1998 - Sep, 1999
Study on Enzymatic Polymorphism and Ethanol Elimination

1994 - 1998
Effects of Acetaldehyde on Ethanol Absorption in the Rat Jejunum

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 1995 - 1996

IJIRI Iwao, FUKE Chiaki, KINOSHITA Hiroshi, AMENO Kiyoshi
法医学、アルコール

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