2012年6月
[Association between lithium sensitivity and GSK3beta gene polymorphisms in bipolar disorder].
Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology
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- 巻
- 32
- 号
- 3
- 開始ページ
- 161
- 終了ページ
- 3
- 記述言語
- 日本語
- 掲載種別
- Scientific Journal
GSK-3beta codes for an enzyme which is a target for the action of mood stabilizers, lithium and possibly of valproic acid. The relationship between the polymorphisms (SNPs) of GSK-3beta-50T/C and -1727A/T and the effect of lithium was studied among 29 Japanese bipolar patients. It was shown that GSK-3beta-50T/C may be linked with the effect of lithium treatment. There is a significantly higher T-allele frequency in the lithium responders than non-responders (df = 1, chi2 = 6.971, 0.01 > P > 0.001; Yates' continuity correction). However, there is not a significant relationship between the polymorphisms of GSK-3beta-1727A/T and the effect of lithium treatment.
- リンク情報
- ID情報
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- ISSN : 1340-2544
- PubMed ID : 22834106