千葉寛 (Kan Chiba) - マイポータル

基本情報

所属: 千葉大学薬学部大学院薬学研究院薬物作用研究部門千葉大学

学位: 博士

J-GLOBAL ID: 200901059201083330
researchmap会員ID: 1000200682

MISC

Identification of human cytochrome P450 isozymes involved in diphenhydramine N-demethylation

Tomoko Akutsu, Kaoru Kobayashi, Koichi Sakurada, Hiroshi Ikegaya, Tomomi Furihata, Kan Chiba

DRUG METABOLISM AND DISPOSITION 35(1) 72-78 2007年1月
Substrate specificity of carboxylesterase isozymes and their contribution to hydrolase activity in human liver and small intestine

Teruko Imai, Megumi Taketani, Mayumi Shii, Masakiyo Hosokawa, Kan Chiba

DRUG METABOLISM AND DISPOSITION 34(10) 1734-1741 2006年10月
Autoinduction of MKC-963 [(R)-1-(1-cyclohexylethylamino)-4-phenylphthalazine] metabolism in healthy volunteers and its retrospective evaluation using primary human hepatocytes and CDNA-expressed enzymes

T Shimizu, K Akimoto, T Yoshimura, T Niwa, K Kobayashi, M Tsunoo, K Chiba

DRUG METABOLISM AND DISPOSITION 34(6) 950-954 2006年6月
Involvement of hepatocyte nuclear factor 4 alpha in the different expression level between CYP2C9 and CYP2C19 in the human liver

S Kawashima, K Kobayashi, K Takama, T Higuchi, T Furihata, M Hosokawa, K Chiba

DRUG METABOLISM AND DISPOSITION 34(6) 1012-1018 2006年6月
Hepatocyte nuclear factor-4 alpha plays pivotal roles in the regulation of mouse carboxylesterase 2 gene transcription in mouse liver

T Furihata, M Hosokawa, M Masuda, T Satoh, K Chiba

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 447(2) 107-117 2006年3月
Hepatocyte nuclear factor-4 alpha plays pivotal roles in the regulation of mouse carboxylesterase 2 gene transcription in mouse liver

T Furihata, M Hosokawa, M Masuda, T Satoh, K Chiba

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 447(2) 107-117 2006年3月
Association of increased type I collagen expression and relative stromal overgrowth in mouse epididymis neonatally exposed to diethylstilbestrol

K Yamazaki, H Fukata, T Adachi, H Tainaka, M Kohda, M Yamazaki, K Kojima, K Chiba, C Mori, M Komiyama

MOLECULAR REPRODUCTION AND DEVELOPMENT 72(3) 291-298 2005年11月
Identification of HMG-CoA reductase inhibitors as activators for human, mouse and rat constitutive androstane receptor

K Kobayashi, Y Yamanaka, N Iwazaki, Nakajo, I, M Hosokawa, M Negishi, K Chiba

DRUG METABOLISM AND DISPOSITION 33(7) 924-929 2005年7月
Functional characterization of SLCO1B1 (OATP-C) variants, SLCO1B1*5, SLCO1B1*15 and SLCO1B1*15+C1007G, by using transient expression systems of HeLa and HEK293 cells

Y Kameyama, K Yamashita, K Kobayashi, M Hosokawa, K Chiba

PHARMACOGENETICS AND GENOMICS 15(7) 513-522 2005年7月
Dexamethasone-induced methylprednisolone hemisuccinate hydrolase: Its identification as a member of the rat carboxylesterase 2 family and its unique existence in plasma

T Furihata, M Hosokawa, A Fujii, M Derbel, T Satoh, K Chiba

BIOCHEMICAL PHARMACOLOGY 69(8) 1287-1297 2005年4月
Gene expression profiling of cathepsin D, metallothioneins-1 and-2, osteopontin, and tenascin-C in a mouse spinal cord injury model by cDNA microarray analysis

M Hashimoto, M Koda, H Ino, K Yoshinaga, A Murata, M Yamazaki, K Kojima, K Chiba, C Mori, H Moriya

ACTA NEUROPATHOLOGICA 109(2) 165-180 2005年2月
Allelic expression imbalance of the human CYP3A4 gene and individual phenotypic status

T Hirota, Ieiri, I, H Takane, S Maegawa, M Hosokawa, K Kobayashi, K Chiba, E Nanba, M Oshimura, T Sato …

HUMAN MOLECULAR GENETICS 13(23) 2959-2969 2004年12月
Pharmacogenetic roles of CYP2C19 and CYP2136 in the metabolism of R- and S-mephobarbital in humans

K Kobavashi, J Morita, K Chiba, A Wanibuchi, M Kimura, S Irie, A Urae, T Ishizaki

PHARMACOGENETICS 14(8) 549-556 2004年8月
Bioactivation of capecitabine in human liver: Involvement of the cytosolic enzyme on 5 '-deoxy-5-fluorocytidine formation

T Tabata, M Katoh, S Tokudome, M Hosakawa, K Chiba, M Nakajima, T Yokoi

DRUG METABOLISM AND DISPOSITION 32(7) 762-767 2004年7月
Key structural features of ligands for activation of human pregnane X receptor

K Kobayashi, S Yamagami, T Higuchi, M Hosokawa, K Chiba

DRUG METABOLISM AND DISPOSITION 32(4) 468-472 2004年4月
A Novel Single Nucleotide Polymorphism (SNP) of the CYP2CI9 Gene in a Japanese Subject with Lowered Capacity of Mephobarbital 4'-Hydroxylation

Jun Morita, Kaoru Kobayashi, Atsuko Wanibuchi, Miyuki Kimura, Shin Irie, Takashi Ishizaki, Kan Chiba

Drug Metabolism And Pharmacokinetics 19(3) 236-238 2004年2月1日
A novel variant allele of OATP-C (SLCO1B1) found in a Japanese patient with pravastatin-induced myopathy

Drug Metab Pharmacokinet 19(6) 453-455 2004年
Catalytic roles of CYP2C9 and its variants (CYP2C9*2 and CYP2C9*3) in lornoxicam 5 '-hydroxylation

Iida, I, A Miyata, M Arai, M Hirota, M Akimoto, S Higuchi, K Kobayashi, K Chiba

DRUG METABOLISM AND DISPOSITION 32(1) 7-9 2004年1月
Catalytic roles of CYP2C9 and its variants (CYP2C9*2 and CYP2C9*3) in lornoxicam 5′-hydroxylation

Izumi Ida, Atsunori Miyata, Masayuki Arai, Mitsuyo Hirota, Masayuki Akimoto, Shohei Higuchi, Kaoru Kobayashi, Kan Chiba

Drug Metabolism and Disposition 32(1) 7-9 2004年1月
Evidence for the involvement of a pulmonary first-pass effect via carboxylesterase in the disposition of a propranolol ester derivative after intravenous administration

T Imai, Y Yoshigae, M Hosokawa, K Chiba, M Otagiri

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 307(3) 1234-1242 2003年12月

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