Background: The PCP pathway controls many cell processes during development. Results: The PCP pathway induces nephrin endocytosis when cultured podocytes are treated with Wnt5a. Loss of PCP protein Vangl2 decreases nephrin endocytosis. Conclusion: During glomerular development, endocytosis of nephrin is regulated by the PCP pathway. Significance: Implicating the PCP pathway in nephrin endocytosis is important for understanding the complexity of PCP signaling during mammalian development. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.