論文

査読有り 国際誌
2020年2月7日

Efficacy and safety of accelerated fractionated radiotherapy without elective nodal irradiation for T3N0 glottic cancer without vocal cord fixation.

Head & neck
  • Masayuki Okumura
  • Atsushi Motegi
  • Sadamoto Zenda
  • Naoki Nakamura
  • Hidehiro Hojo
  • Masaki Nakamura
  • Yasuhiro Hirano
  • Shun-Ichiro Kageyama
  • Satoko Arahira
  • Raturi Vijay Parshuram
  • Hirofumi Kuno
  • Ryuichi Hayashi
  • Makoto Tahara
  • Yoshiyuki Itoh
  • Shinji Naganawa
  • Tetsuo Akimoto
  • 全て表示

42
8
開始ページ
1775
終了ページ
1782
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1002/hed.26092

BACKGROUND: The purpose of this study was to evaluate accelerated fractionated radiotherapy (AFRT) without elective nodal irradiation (ENI) for T3N0 glottic cancer (GC) without vocal cord fixation, especially in comparison with chemoradiotherapy (CRT) and hyperfractionated radiotherapy (HFRT) both of which included ENI. METHODS: The medical charts of patients with T3N0GC without cord fixation received definitive radiotherapy between June 2005 and March 2018 were reviewed. RESULTS: A total of 74 patients were analyzed. After a median follow-up time of 46 months (range, 12-141), 3-year local failure in AFRT/CRT/HFRT (n = 41/10/23) was 10%/20%/26%, 3-year regional failure 6%/0%/9%, 3-year progression-free survival 71%/69%/74%, and 3-year overall survival 77%/100%/87%. There were no significant differences among three groups in recurrence or survival. Grade 3 adverse events (AEs) were noted in 5/2/8 patients (12%/20%/35%) in AFRT/CRT/HFRT, respectively. There were no Grade 4/5 AEs. CONCLUSIONS: AFRT without ENI is an effective and feasible treatment for T3N0GC without cord fixation.

リンク情報
DOI
https://doi.org/10.1002/hed.26092
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32031301
ID情報
  • DOI : 10.1002/hed.26092
  • PubMed ID : 32031301

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