2016年4月
Liquid-like behavior of chromatin
CURRENT OPINION IN GENETICS & DEVELOPMENT
- ,
- ,
- ,
- 巻
- 37
- 号
- 開始ページ
- 36
- 終了ページ
- 45
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.gde.2015.11.006
- 出版者・発行元
- CURRENT BIOLOGY LTD
Eukaryotic chromatin is a negatively charged long polymer composed of genomic DNA, histones, and various proteins. The charged property causes the chromatin structure to be dynamically changed. These dynamic changes are critical for genome functions such as gene expression because they directly govern the degree of DNA accessibility. Although the chromatin structure is not yet fully understood, currently increasing evidence suggests that chromatin has a dynamic liquid-like structure based on the 10-nm fiber but not the 30-nm fiber. This liquid-like property can drive the process of 'scanning and targeting genomic DNA,' which contributes to various genome functions including gene expression and DNA replication, repair, and recombination. Here, we discuss the liquid-like behavior of chromatin and its physical and biological relevance.
- リンク情報
- ID情報
-
- DOI : 10.1016/j.gde.2015.11.006
- ISSN : 0959-437X
- eISSN : 1879-0380
- Web of Science ID : WOS:000378067300006