早川芳宏 (Yoshihiro Hayakawa) - マイポータル - researchmap

基本情報

所属: 名古屋大学大学院情報科学研究科複雑系科学専攻大学院情報科学研究科複雑系科学専攻教授

学位: 博士(理学)

J-GLOBAL ID: 200901035713971126
researchmap会員ID: 1000201118

研究分野

2

受賞

3

MISC

236

c-di-GMP is an effective immunomodulator and vaccine adjuvant against pneumococcal infection.

Vaccine 26 4675-4695 2008年
バイオフィルム感染症特効薬としての可能性を秘めるc-di-GMP

早川芳宏

化学と生物 46(7) 444-446 2008年
c-di-GMP is an effective immunomodulator and vaccine adjuvant against pneumococcal infection.

Vaccine 26 4675-4695 2008年
Synthesis of cyclic bis(3'-5')-2'deoxyguanylic/guanylic acid (c-dGpGp) and its biological activities to microbes

Erina Mano, Mamoru Hyodo, Yumi Sato, Yuka Ishihara, Michio Ohta, Yoshihiro Hayakawa

CHEMMEDCHEM 2(10) 1410-1413 2007年10月
Cyclic Di-GMP stimulates protective innate immunity in bacterial pneumonia

David K. R. Karaolis, Michael W. Newstead, Xianying Zeng, Mamoru Hyodo, Yoshihiro Hayakawa, Urvhashi Bhan, Hallie Liang, Theodore J. Standiford

INFECTION AND IMMUNITY 75(10) 4942-4950 2007年10月
A new synthetic route to oligoribonucleotides based on CpRu-catalyzed deallylation

Shinji Tanaka, Takuya Hirakawa, Kazuhiro Oishi, Yoshihiro Hayakawa, Masato Kitamura

TETRAHEDRON LETTERS 48(41) 7320-7322 2007年10月
A cyclic-di-GMP receptor required for bacterial exopolysaccharide production

Vincent T. Lee, Jody M. Matewish, Jennifer L. Kessler, Mamoru Hyodo, Yoshihiro Hayakawa, Stephen Lory

MOLECULAR MICROBIOLOGY 65(6) 1474-1484 2007年9月
The second messenger bis-(3 '-5 ')-cyclic-GMP and its PilZ domain-containing receptor Alg44 are required for alginate biosynthesis in Pseudomonas aeruginosa

Massimo Merighi, Vincent T. Lee, Mamoru Hyodo, Yoshihiro Hayakawa, Stephen Lory

MOLECULAR MICROBIOLOGY 65(4) 876-895 2007年8月
Bacterial c-di-GMP is an immunostimulatory molecule

David K. R. Karaolis, Terry K. Means, De Yang, Munehisa Takahashi, Teizo Yoshimura, Eric Muraille, Dana Philpott, John T. Schroeder, Mamoru Hyodo, Yoshihiro Hayakawa …

JOURNAL OF IMMUNOLOGY 178(4) 2171-2181 2007年2月
Binding affinity of a peptide-nucleic acid containing pyrimido[4,5-d]pyrimidine-2,4,5,7-(1H,3H,6H,8H)-tetraone as a nucleobase for oligonucleotides.

Nucleic Acids Symp. Ser. (51) 257-258 2007年
Preparation of an artificial ribonucleoside with pyrimido[4,5d] pyrimidine-2,4,5,7-(1H,3H,6H,8H)-tetraone as a base and its discriminating ability for natural Nucleosides

Taisuke Hirano, Kenji Kuroda, Hidehiko Kodama, Masanori Kataoka, Yoshihiro Hayakawa

LETTERS IN ORGANIC CHEMISTRY 4(8) 530-534 2007年
Binding affinity of a peptide-nucleic acid containing pyrimido[4,5-d]pyrimidine-2,4,5,7-(1H,3H,6H,8H)-tetraone as a nucleobase for oligonucleotides.

Nucleic Acids Symp. Ser. (51) 257-258 2007年
Control of formation and cellular detachment from Shewanella oneidensis MR-1 biofilms by cyclic di-GMP

KM Thormann, S Duttler, RM Saville, M Hyodo, S Shukla, Y Hayakawa, AM Spormann

JOURNAL OF BACTERIOLOGY 188(7) 2681-2691 2006年4月
Genome-wide transcriptional profile of Escherichia coli in response to high levels of the second messenger 3 ',5 '-cyclic diguanylic acid

MM Mendez-Ortiz, M Hyodo, Y Hayakawa, J Membrillo-Hernandez

JOURNAL OF BIOLOGICAL CHEMISTRY 281(12) 8090-8099 2006年3月
Synthesis of cyclic bis(3 '-5 ')diguanylic acid (c-di-GMP) analogs

M Hyodo, Y Sato, Y Hayakawa

TETRAHEDRON 62(13) 3089-3094 2006年3月
Analysis of Pseudomonas aeruginosa diguanylate cyclases and phosphodiesterases reveals a role for bis-(3 '-5 ')-cyclic-GMP in virulence

H Kulesekara, Lee, V, A Brencic, N Liberati, J Urbach, S Miyata, DG Lee, AN Neely, M Hyodo, Y Hayakawa …

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 103(8) 2839-2844 2006年2月
A ribonucleoside with pyrimido[4,5-d]pyrimidine-2,4,5,7-(1H,3H,6H,8H)-tetraone as a nucleobase, which universally binds to natural nucleosides.

Nucleic Acids Symp. Ser. 50 17-18 2006年
A strategy for the stereoselective preparation of dithymidine phosphorothioates with an R or S configuration of the stereogenic phosphorus atom and its application to the synthesis of oligodeoxyribonucleotides with stereochemically pure phosphate/phosp・・・

HAYAKAWA Yoshihiro, HAYAKAWA Yoshihiro, HIRABAYASHI Yoshiko, HYODO Mamoru, YAMASHITA Satoko, MATSUNAMI Tomoyuki, CUI Dong‐Mei, KAWAI Rie, KODAMA Hidehiko

Eur. J. Org. Chem. 2006(17) 3834-3844 2006年
環状ビス(3'-5')ジグアニル酸（c-di-GMP）および類縁体の有機合成、化学的性質、および生物活性。

兵藤守, 早川芳宏

有機合成化学協会誌 64(4) 359-370 2006年
A ribonucleoside with pyrimido[4,5-d]pyrimidine-2,4,5,7-(1H,3H,6H,8H)-tetraone as a nucleobase, which universally binds to natural nucleosides.

Nucleic Acids Symp. Ser. 50 17-18 2006年

もっとみる

書籍等出版物

34

Nucleobase Protection with Allyloxycarbonyl. In Current Protocols in Nucleic Acid Chemistry

John Wiley & Sons 2005年
Benzimidazolium Trifluoromethanesulfonate. In "Handbook of Reagents for Organic Synthesis: Reagents for Glycoside, Nucleotide, and Peptide Synthesis", D. Crich, Ed.

John Wiley & Sons 2005年
Ally Tetraisoproylphosphorodiamidite. In "Handbook of Reagents for Organic Synthesis: Reagents for Glycoside, Nucleotide, and Peptide Synthesis", D. Crich, Ed.

John Wiley & Sons 2005年
Nucleobase Protection with Allyloxycarbonyl.

John Wiley & Sons 2005年
EDITORIAL. In "Frontiers in Organic Chemistry", Atta-ur-Rahman and Y, Hayakawa, Eds.

Bentham 2005年
Strategies Useful for the Chemical Synthesis of Oligonucleotides and Related Compounds. In "Frontiers in Organic Chemistry", Atta-ur-Rahman and Y, Hayakawa, Eds.

Bentham 2005年
Nucleobase Protection with Allyloxycarbonyl. In Current Protocols in Nucleic Acid Chemistry

John Wiley & Sons 2005年
Benzimidazolium Trifluoromethanesulfonate. In "Handbook of Reagents for Organic Synthesis: Reagents for Glycoside, Nucleotide, and Peptide Synthesis", D. Crich, Ed.

John Wiley & Sons 2005年
Ally Tetraisoproylphosphorodiamidite. In "Handbook of Reagents for Organic Synthesis: Reagents for Glycoside, Nucleotide, and Peptide Synthesis", D. Crich, Ed.

John Wiley & Sons 2005年
Nucleobase Protection with Allyloxycarbonyl.

John Wiley & Sons 2005年
EDITORIAL. In "Frontiers in Organic Chemistry", Atta-ur-Rahman and Y, Hayakawa, Eds.

Bentham 2005年
Strategies Useful for the Chemical Synthesis of Oligonucleotides and Related Compounds. In "Frontiers in Organic Chemistry", Atta-ur-Rahman and Y, Hayakawa, Eds.

Bentham 2005年
ヌクレオシド、ヌクレオチドおよび核酸類。「化学便覧基礎編改訂第５版－第I巻」

丸善 2004年
ゲノムケミストリーを可能にする新技術。「ゲノムケミストリー」第１章

講談社 2003年
核酸関連物質。「有機薬科学実験講座第３巻－創薬化学の基礎となる先導物質の合成法I」第３章

廣川書店 1996年
α,α'-Dibromoacetone

John Wiley & Sons 1995年
α,α'-Dibromoacetone

John Wiley & Sons 1995年
均一系熱化学反応-人名反応。「化学便覧基礎編改訂第４版－第II巻」

丸善 1993年
リン酸エステル

第４版実験化学講座 1992年
Esters of Phosphoric Acid

1992年

もっとみる

所属学協会

3

Works(作品等)

5

共同研究・競争的資金等の研究課題

6

産業財産権

13