Shun-ichiro Kawabata

Profile Information

Affiliation: Kyushu University

Degree: (BLANK)

J-GLOBAL ID: 200901048166839824
researchmap Member ID: 1000201625

External link: http://www.biology.kyushu-u.ac.jp/~biopoly/index.html

Research Interests

Research Areas

Research History

2004 - Present

Professor, Faculty of Science, Kyushu University
1997 - 2004

Associate Professor, Faculty of Sciences, Kyushu University
1986 - 1997

School of Science, Kyushu University
1985 - 1986

School of Science, Kyushu University

Education

1981 - 1986

Kyushu University
1980 - 1981

Department of Biology, School of Sciences, Kyushu University
1976 - 1980

Department of Biology, School of Sciences, Kyushu University

Committee Memberships

Mar, 2018 - Mar, 2021

論文編集委員, 日本生化学会
Apr, 2016 - Dec, 2020

理事・運営委員, 日本生体防御学会
Jan, 2001 - Dec, 2020

運営委員, 日本エンドトキシン・自然免疫研究会
Nov, 2013 - Nov, 2015

理事, 日本生化学会
Nov, 2013 - Nov, 2015

日本生化学会九州支部長, 日本生化学会
Oct, 2012 - Oct, 2015

代議員, 日本生化学会
2000 - 2007

運営委員,理事, 日本生体防御学会
Apr, 2006

副会長, 日本比較免疫学会
Jan, 2001

理事, 日本生体防御学会
2001

理事, 日本蛋白質科学会
世話人, 日本エンドトキシン研究会

Awards

Jan, 2011

Developmental and Comparative Immunology Top Reviewer 2009-2010, Elsevier
Aug, 2008

比較免疫学会古田賞, 日本比較免疫学会
1995

日本生化学会奨励賞, 日本生化学会

Major Papers

Roles of the clip domains of two protease zymogens in the coagulation cascade in horseshoe crabs

Keisuke Yamashita, Toshio Shibata, Toshiaki Takahashi, Yuki Kobayashi, Shun-ichiro Kawabata

JOURNAL OF BIOLOGICAL CHEMISTRY, 295(26) 8857-8866, Jun, 2020 Peer-reviewedCorresponding author
Intermolecular autocatalytic activation of serine protease zymogen factor C through an active transition state responding to lipopolysaccharide

Toshio Shibata, Yuki Kobayashi, Yuto Ikeda, Shun-ichiro Kawabata

JOURNAL OF BIOLOGICAL CHEMISTRY, 293(29) 11589-11599, Jul, 2018 Peer-reviewed
Drosophila TG-A transglutaminase is secreted via an unconventional Golgi-independent mechanism involving exosomes and two types of fatty acylations

Toshio Shibata, Jinki Hadano, Daichi Kawasaki, Xiaoqing Dong, Shun-ichiro Kawabata

JOURNAL OF BIOLOGICAL CHEMISTRY, 292(25) 10723-10734, Jun, 2017 Peer-reviewed
Transglutaminase-catalyzed incorporation of polyamines masks the DNA-binding region of the transcription factor relish.

Maki, K., Shibata, T., and Kawabata, S.

J. Biol. Chem., 292 10723-10734, Apr, 2017 Peer-reviewed
Genetic engineering approach to develop next-generation reagents for endotoxin quantification

Hikaru Mizumura, Norihiko Ogura, Jun Aketagawa, Maki Aizawa, Yuki Kobayashi, Shun-Ichiro Kawabata, Toshio Oda

INNATE IMMUNITY, 23(2) 136-146, Feb, 2017 Peer-reviewed
RNA interference directed against the transglutaminase gene triggers dysbiosis of gut microbiota in Drosophila.

Sekihara, S., Shibata, T., Hyakkendani, M., and Kawabata, S.

J. Biol. Chem., (291) 25077-25087, Nov, 2016 Peer-reviewed
Crosslinking of a peritrophic matrix protein protects gut epithelia from bacterial exotoxins.

Shun-ichiro Kawabata

PLoS Pathog., 11 e1005244, Oct, 2015 Peer-reviewed
Crosslinking of a peritrophic matrix protein protects gut epithelia from bacterial exotoxins.

Shun-ichiro Kawabata

PLoS Pathog., 11 e1005244, Oct, 2015 Peer-reviewed
Factor B Is the Second Lipopolysaccharide-binding Protease Zymogen in the Horseshoe Crab Coagulation Cascade

Yuki Kobayashi, Toshiaki Takahashi, Toshio Shibata, Shunsuke Ikeda, Takumi Koshiba, Hikaru Mizumura, Toshio Oda, Shun-ichiro Kawabata

JOURNAL OF BIOLOGICAL CHEMISTRY, 290(31) 19379-19386, Jul, 2015 Peer-reviewed
The N-terminal Arg Residue Is Essential for Autocatalytic Activation of a Lipopolysaccharide-responsive Protease Zymogen

Yuki Kobayashi, Takafumi Shiga, Toshio Shibata, Miyuki Sako, Katsumi Maenaka, Takumi Koshiba, Hikaru Mizumura, Toshio Oda, Shun-ichiro Kawabata

JOURNAL OF BIOLOGICAL CHEMISTRY, 289(37) 25987-25995, Sep, 2014 Peer-reviewed
Interaction between tachyplesin I, an antimicrobial peptide derived from horseshoe crab, and lipopolysaccharide

Takahiro Kushibiki, Masakatsu Kamiya, Tomoyasu Aizawa, Yasuhiro Kumaki, Takashi Kikukawa, Mineyuki Mizuguchi, Makoto Demura, Shun-ichiro Kawabata, Keiichi Kawano

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1844(3) 527-534, Mar, 2014 Peer-reviewed
Transglutaminase-Catalyzed Protein-Protein Cross-Linking Suppresses the Activity of the NF-κB-like Transcription Factor Relish

Shun-ichiro Kawabata

Science Signaling, 6(285) ra61, Jul, 2013 Peer-reviewed
Microbe-Specific C3b Deposition in the Horseshoe Crab Complement System in a C2/Factor B-Dependent or -Independent Manner

Keisuke Tagawa, Toyoki Yoshihara, Toshio Shibata, Kazuki Kitazaki, Yuichi Endo, Teizo Fujita, Takumi Koshiba, Shun-ichiro Kawabata

PLOS ONE, 7(5), May, 2012 Peer-reviewed
Mitochondrial membrane potential is involved in the MAVS-mediated antiviral signaling.

Koshiba, T., Yasukawa, K., Yanagi, Y., and Kawabata, S.

Science Signaling, Feb, 2011 Peer-reviewed
Mitochondrial membrane potential is required for MAVS-mediated antiviral signaling

Takumi Koshiba, Kai Yasukawa, Yusuke Yanagi, Shun-Ichiro Kawabata

Science Signaling, 4(158), Feb 1, 2011 Peer-reviewed
Purification and characterization of tributyltin-binding protein of tiger puffer, Takifugu rubripes

Yumi Oba, Akira Yamauchi, Yasuyuki Hashiguchi, Hina Satone, Shizuho Miki, Mohamed Nassef, Yohei Shimasaki, Takeshi Kitano, Miki Nakao, Shun-Ichiro Kawabata …

Comparative Biochemistry and Physiology - C Toxicology and Pharmacology, 153(1) 17-23, Jan, 2011 Peer-reviewed
Protein Crosslinking by Transglutaminase Controls Cuticle Morphogenesis in Drosophila

Toshio Shibata, Shigeru Ariki, Naoaki Shinzawa, Ryuta Miyaji, Haruka Suyama, Miyuki Sako, Nobuyuki Inomata, Takumi Koshiba, Hirotaka Kanuka, Shun-ichiro Kawabata

PLOS ONE, 5(10), Oct, 2010 Peer-reviewed
IMMUNOCOMPETENT MOLECULES AND THEIR RESPONSE NETWORK IN HORSESHOE CRABS

Shun-ichiro Kawabata

INVERTEBRATE IMMUNITY, 708 122-136, 2010 Peer-reviewed
Factor G Utilizes a Carbohydrate-Binding Cleft That Is Conserved between Horseshoe Crab and Bacteria for the Recognition of beta-1,3-D-Glucans

Yuki Ueda, Shuhei Ohwada, Yoshito Abe, Toshio Shibata, Manabu Iijima, Yukiko Yoshimitsu, Takumi Koshiba, Munehiro Nakata, Tadashi Ueda, Shun-ichiro Kawabata

JOURNAL OF IMMUNOLOGY, 183(6) 3810-3818, Sep, 2009 Peer-reviewed
Factor C Acts as a Lipopolysaccharide-Responsive C3 Convertase in Horseshoe Crab Complement Activation

Shigeru Ariki, Shusaku Takahara, Toshio Shibata, Takaaki Fukuoka, Aya Ozaki, Yuichi Endo, Teizo Fujita, Takumi Koshiba, Shun-ichiro Kawabata

JOURNAL OF IMMUNOLOGY, 181(11) 7994-8001, Dec, 2008 Peer-reviewed
An arthropod cuticular chitin-binding protein endows injured sites with transglutaminase-dependent mesh

Yasuyuki Matsuda, Takumi Koshiba, Tsukasa Osaki, Haruka Suyama, Fumio Arisaka, Yoshihiro Toh, Shun-ichiro Kawabata

JOURNAL OF BIOLOGICAL CHEMISTRY, 282(52) 37316-37324, Dec, 2007 Peer-reviewed
A structural perspective on the interaction between lipopolysaccharide and Factor C, a receptor involved in recognition of Gram-negative bacteria

Takumi Koshiba, Tornoyuki Hashii, Shun-ichiro Kawabata

JOURNAL OF BIOLOGICAL CHEMISTRY, 282(6) 3962-3967, Feb, 2007 Peer-reviewed
Horseshoe crab hemocyte-derived lectin recognizing specific O-antigens of lipopolysaccharides

K Inamori, T Saito, D Iwaki, T Nagira, S Iwanaga, F Arisaka, S Kawabata

PHYLOGENETIC PERSPECTIVES ON THE VERTEBRATE IMMUNE SYSTEM, 484 185-190, 2001 Peer-reviewed
Purification, characterization, and cDNA cloning of a 27-kDa lectin (L10) from horseshoe crab hemocytes

N Okino, S Kawabata, T Saito, M Hirata, T Takagi, S Iwanaga

JOURNAL OF BIOLOGICAL CHEMISTRY, 270(52) 31008-31015, Dec, 1995 Peer-reviewed
NUCLEOTIDE-SEQUENCE OF THE CDNA-ENCODING THE PROENZYME OF PHENOL OXIDASE A(1) OF DROSOPHILA-MELANOGASTER

K FUJIMOTO, N OKINO, S KAWABATA, S IWANAGA, E OHNISHI

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 92(17) 7769-7773, Aug, 1995 Peer-reviewed
A NOVEL BIG DEFENSIN IDENTIFIED IN HORSESHOE-CRAB HEMOCYTES - ISOLATION, AMINO-ACID-SEQUENCE, AND ANTIBACTERIAL ACTIVITY

T SAITO, S KAWABATA, T SHIGENAGA, Y TAKAYENOKI, JK CHO, H NAKAJIMA, M HIRATA, S IWANAGA

JOURNAL OF BIOCHEMISTRY, 117(5) 1131-1137, May, 1995 Peer-reviewed

Major Misc.

Pluripotency and a secretion mechanism of Drosophila Transglutaminase.

Shibata, T. and Kawabata, S.

Mar, 2018
Transglutaminase in Invertebrates.

Shun-ichiro Kawabata

Jun, 2016
The lipopolysaccharide-activated innate immune response network of the horseshoe crab

Shun-ichiro Kawabata, Takumi Koshiba, Toshio Shibata

May, 2009

Major Books and Other Publications

Transglutaminases: Multiple functional modifiers and targets for new drug discovery

T. Shibata and S. Kawabata (Role: Joint author)

Springer, Mar, 2015
生体防御医学事典

川畑俊一郎

May, 2007

Professional Memberships

Works

カブトガニ生体防御系（種々のレクチンおよび凝固因子）の高度利用

2002

Research Projects

Academic Activities

Journal of Biochemistry

Review, evaluation

Mar, 2018 - Mar, 2020
Microbiology and Immunology

Review, evaluation

Jan, 2005 - Dec, 2017
Developmental and Comparative Immunology

Peer review

Jan, 2000 - Dec, 2017
Journal of Biochemistry

Peer review

Apr, 2008 - Mar, 2016

Profile Information

Research Interests

Research Areas

Research History

Education

Committee Memberships

Awards

Major Papers

Major Misc.

Major Books and Other Publications

Professional Memberships

Works

Research Projects

Academic Activities

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