大和田智彦 (Tomohiko Ohwada) - マイポータル - researchmap

基本情報

所属: 東京大学大学院薬学系研究科分子薬学専攻教授

学位: 薬学博士(東京大学)
薬学修士(東京大学)

J-GLOBAL ID: 200901059831827451
researchmap会員ID: 1000202050

外部リンク: http://www.f.u-tokyo.ac.jp/~yakka/

研究キーワード

10

研究分野

3

経歴

9

1998年 - 2001年

名古屋市立大学薬学部教授
1998年 - 2001年

名古屋市立大学
2001年

- 東京大学大学院薬学系研究科教授
2001年

- Graduate School of Pharmaceutical Sciences
1985年 - 1998年

東京大学大学院薬学系研究科助手
1985年 - 1998年

Graduate School of Pharmaceutical Sciences
University of Tokyo Professor
Pharmaceutical Sciences, Professor
University of Tokyo, Assistant Professor

学歴

2

- 1982年

東京大学, 薬学部, 薬学
- 1982年

東京大学

受賞

1

1992年

日本薬学会奨励賞

MISC

22

Design, synthesis, and characterization of BK channel openers based on oximation of abietane diterpene derivatives

Yong-Mei Cui, Eriko Yasutomi, Yuko Otani, Katsutoshi Ido, Takashi Yoshinaga, Kohei Sawada, Tomohiko Ohwada

BIOORGANIC & MEDICINAL CHEMISTRY 18(24) 8642-8659 2010年12月
Water-stable Helical Structure of Tertiary Amides of Bicyclic β-Amino Acid Bearing 7-Azabicyclo[2.2.1]heptane. Full Control of Amide Cis-Trans Equilibrium by Bridgehead Substitution

Masahiro Hosoya, Yuko Otani, Masatoshi Kawahata, Kentaro Yamaguchi, Tomohiko Ohwada

Journal of the American Chemical Society 132(42) 14780-14789 2010年10月
Cyclization of Arylacetoacetates to Indene and Dihydronaphthalene Derivatives in Strong Acids. Evidence for Involvement of Further Protonation of O,O-Diprotonated beta-Ketoester, Leading to Enhancement of Cyclization

Hiroaki Kurouchi, Hiromichi Sugimoto, Yuko Otani, Tomohiko Ohwada

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 132(2) 807-815 2010年1月
Synthesis and Evaluation of Lysophosphatidylserine Analogues as Inducers of Mast Cell Degranulation. Potent Activities of Lysophosphatidylthreonine and Its 2-Deoxy Derivative

Masazumi Iwashita, Kumiko Makide, Taro Nonomura, Yoshimasa Misumi, Yuko Otani, Mayuko Ishida, Ryo Taguchi, Masafumi Tsujimoto, Junken Aoki, Hiroyuki Arai …

JOURNAL OF MEDICINAL CHEMISTRY 52(19) 5837-5863 2009年10月
Transnitrosation of thiols from aliphatic N-nitrosamines: S-nitrosation and indirect generation of nitric oxide

Takahiro Yanagimoto, Takeshi Toyota, Norio Matsuki, Yumi Makino, Seiichi Uchiyama, Tomohiko Ohwada

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 129(4) 736-737 2007年1月
Molecular basis of primarian compounds as novel activators of large conductance Ca²⁺ activated lc⁺ chammel a-subanit

Molecular Pharmacology 62, 836-846 2002年
Generation of Fumction alized Asymmetric Benzynes using TMP-Zincates, Effects of Cigonds on Selectivity and Reactivity of Zincates

J. Am. Chem. Soc. 124, 8514-8515 2002年
Usefulness and limitation of DiBAC(4)(3), a voltage-sensitive fluorescent dye, for the measurement of membrane potentials regulated by recombinant large conductance Ca2+-activated K+ channels in HEK293 cells

A Yamada, N Gaja, S Ohya, K Muraki, H Narita, T Ohwada, Y Imaizumi

JAPANESE JOURNAL OF PHARMACOLOGY 86(3) 342-350 2001年7月
Space-filling effects in membrane disruption by cationic amphiphiles

T Fujiwara, N Hirashima, S Hasegawa, M Nakanishi, T Ohwada

BIOORGANIC & MEDICINAL CHEMISTRY 9(4) 1013-1024 2001年4月
Structural Features of Aliphatic N-Nitrosamines of 7-Azabicyclo[2.2.1]heptanes That Facilitate N-NO Bond Cleavage(共著)

┣DBJ. Am. Chem. Soc.(/)-┫DB 123, 10164-10172 2001年
Anchoring and Bola Cationic Amphiphiles for Nucleotide Delivery. Effects of Orientation and Extension of Hydrophobic Regions(共著)

┣DBBioorganic & Medicinal Chemisty Letters(/)-┫DB 11, 2987-2901 2001年
Stereoselction of Sterically Unbiased Diels-Alder Dienes with Spiro Conjugation.(共著)

┣DBTetrahedron Letters(/)-┫DB 42(31) 5257-5260 2001年
Regioselective Superacid-Catalyzed Electrocyclization of Diphenylmethyl Cations. Fluorenes, Phenanthrol and Benzofuran Cyclizations.(共著)

┣DBSynthesis(/)-┫DB in press 2001年
Mutation spectrum of o-aminoazotoluene in the cll gene of lambda/lacZ transgenic mice(Muta(^TM)Mouse).(共著)

┣DBMutation Research/Genetic Toxicology and Environmental Mutagenesis(/)-┫DB 491 211-220 2001年
Gene Transfection activities of amphiphilic Steroid-polyamine Conjugates(共著)

┣DBBiochim. Biophys. Acta(/)-┫DB 1468 396-402 2000年
Influenec of Structure on N-NO bond cleavage of aliphatic N-nitrosamines.(共著)

┣DBTetrahedron Letters(/)-┫DB 41(19) 3637-3641 2000年
Orbital-controlled stereoselections in sterically unbiased cyclic systems

T Ohwada

CHEMICAL REVIEWS 99(5) 1337-1375 1999年5月
Superacid-catalyzed electrocyclization of 1-phenyl-2-propen-1-ones to 1-indanones. Kinetic and theoretical studies of electrocyclization of oxonium-carbenium dications

T Suzuki, T Ohwada, K Shudo

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 119(29) 6774-6780 1997年7月
Three-center, two-electron systems. Origin of the tilting of their substituents

K Lammertsma, T Ohwada

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 118(31) 7247-7254 1996年8月
Orbital unsymmetrization affects facial selectivities of Diels-Alder dienophiles

Okamoto, I, T Ohwada, K Shudo

JOURNAL OF ORGANIC CHEMISTRY 61(9) 3155-3166 1996年5月

もっとみる

書籍等出版物

2

Topics in Current Chemistry, Orbitals in Chemistry, Satoshi Inagaki (ed)

Springler, 2010年
Electrophilic Species that can React with Benzene are Dicationic

Stable Carbocation Chemistry Edited by G. K. S. Pralcash. and. P. U. R. Schleyer John Wiley & Sons, Inc 1997年

講演・口頭発表等

4

Aromatic Multifunctionalization Reactions Based on Highly Reactive? Cationic Intermediates

Chemical Challenges for the 21st Century, USC, Loker Hydrocarbon Research Institute 2007年招待有り
Kendari International Conference on Medicinal Chemistry and Pharmacy Education (KICMCPE 2015) : Structure-Activity Relationships of Lysophospholipid Analogues as Agonists of Membrane Receptors, November 25, 2015, Kendari, Indonesia

招待有り
Symposium on Foldamers 2015, IECB, Bordeaux-Pessac, France, January 26-28, 2015 Oral Communication (OC7) Robust Cis- and Trans-Amide Helical Structures of Oligomers ofBicyclic Mimics of β-Proline: Full Contorol of Amide Cis-Trans Equilibrium

Tomohiko Ohwada
"Current Chemical Challenges" University of Southern California, CA, USA The Loker Hydrocarbon Research Institute Celebrate the 35th Anniversary of the Loker Hydrocarbon Research Institute and the 85th Birthday of Professor George A. Olah with a chemistry

Tomohiko Ohwada

招待有り

所属学協会

4

Works(作品等)

3

遺伝子送達分子の開発

1998年
Synthesis and evaluation of Ion Channel openers

1998年
Synthesis of gene transfection molecules

1998年

共同研究・競争的資金等の研究課題

9