武藤誠 (Makoto Taketo) - マイポータル

基本情報

所属: 京都大学大学院医学研究科医学専攻教授

学位: 医学博士(京都大学)

J-GLOBAL ID: 200901075929706267
researchmap会員ID: 1000202055

外部リンク: http://www4.mfour.med.kyoto-u.ac.jp

研究キーワード

研究分野

学歴

委員歴

2002年 - 2003年

AACR(米国癌学会), Cancer Research Associate Editor(準編集員)
2002年

ASBMB(米国生化学・分子生物学会), FASEB J. Associate Editor(準編集員)
1998年

日本癌学会, 評議員

受賞

2004年

佐川特別研究助成賞

論文

365

Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine

Yu Muta, Yoshihisa Fujita, Kenta Sumiyama, Atsuro Sakurai, M. Mark Taketo, Tsutomu Chiba, Hiroshi Seno, Kazuhiro Aoki, Michiyuki Matsuda, Masamichi Imajo

Nature Communications 9(1) 2174-- 2018年12月1日査読有り
A Chemosensitivity Study of Colorectal Cancer Using Xenografts of Patient-Derived Tumor-Initiating Cells.

Hisatsugu Maekawa, Hiroyuki Miyoshi, Tadayoshi Yamaura, Yoshiro Itatani, Kenji Kawada, Yoshiharu Sakai, M Mark Taketo

Molecular cancer therapeutics 17(10) 2187-2196 2018年10月査読有り
Canonical Wnt signaling regulates patterning, differentiation and nucleogenesis in mouse hypothalamus and prethalamus.

Newman EA, Wu D, Taketo MM, Zhang J, Blackshaw S

Developmental biology 442(2) 236-248 2018年10月査読有り
Transgenic mice that accept Luciferase- or GFP-expressing syngeneic tumor cells at high efficiencies.

武藤誠

Genes Cells 23(7) 580-589 2018年7月査読有り
Dissecting Wnt Signaling for Melanocyte Regulation during Wound Healing

Qi Sun, Piul Rabbani, Makoto Takeo, Soung-Hoon Lee, Chae Ho Lim, EN-Nekema Shandi Noel, M. Mark Taketo, Peggy Myung, Sarah Millar, Mayumi Ito

Journal of Investigative Dermatology 138(7) 1591-1600 2018年7月1日査読有り
Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis

Paul K. Ziegler, Julia Bollrath, Charles K. Pallangyo, Takaji Matsutani, Özge Canli, Tiago De Oliveira, Michaela A. Diamanti, Nina Müller, Jaba Gamrekelashvili, Tracy Putoczki …

Cell 174(1) 88-101.e16 2018年6月28日査読有り
Activated renal tubular Wnt/β-catenin signaling triggers renal inflammation during overload proteinuria

武藤誠

Kidney Int 93(6) 1367-1383 2018年6月1日査読有り
Targeting β-Catenin in GLAST-Expressing Cells: Impact on Anxiety and Depression-Related Behavior and Hippocampal Proliferation

武藤誠

Molec Neurobiol -(-) 1-14 2018年5月8日査読有り
An improved method for culturing patient-derived colorectal cancer spheroids.

Hiroyuki Miyoshi, Hisatsugu Maekawa, Fumihiko Kakizaki, Tadayoshi Yamaura, Kenji Kawada, Yoshiharu Sakai, M Mark Taketo

Oncotarget 9(31) 21950-21964 2018年4月24日査読有り
Wnt inhibition promotes vascular specification of embryonic cardiac progenitors

David E. Reichman, Laura Park, Limor Man, David Redmond, Kenny Chao, Richard P. Harvey, Makoto M. Taketo, Zev Rosenwaks, Daylon James

Development (Cambridge) 145(1) --- 2018年1月1日査読有り
Hepatocyte specific expression of an oncogenic variant of β-catenin results in lethal metabolic dysfunction in mice

武藤誠

Oncotarget 9(13) 11243-11257 2018年査読有り
mTORC1-Mediated Inhibition of 4EBP1 Is Essential for Hedgehog Signaling-Driven Translation and Medulloblastoma

Chang-Chih Wu, Shirui Hou, Brent A. Orr, Bryan R. Kuo, Yong Ha Youn, Taren Ong, Fanny Roth, Charles G. Eberhart, Giles W. Robinson, David J. Solecki …

DEVELOPMENTAL CELL 43(6) 673-+ 2017年12月査読有り
Blocking TGF-β and β-Catenin Epithelial Crosstalk Exacerbates CKD

武藤誠

J Am Soc Nephrol 28(12) 3490-3503 2017年12月査読有り
Tumor microenvironment confers mTOR inhibitor resistance in invasive intestinal adenocarcinoma

T. Fujishita, Y. Kojima, R. Kajino-Sakamoto, M. M. Taketo, M. Aoki

ONCOGENE 36(46) 6480-6489 2017年11月査読有り
Canonical WNT Signaling Regulates the Pituitary Organizer and Pituitary Gland Formation

Allison M. Osmundsen, Jessica L. Keisler, M. Mark Taketo, Shannon W. Davis

ENDOCRINOLOGY 158(10) 3339-3353 2017年10月査読有り
Intestinal cancer progression by mutant p53 through the acquisition of invasiveness associated with complex glandular formation

M. Nakayama, E. Sakai, K. Echizen, Y. Yamada, H. Oshima, T-S Han, R. Ohki, S. Fujii, A. Ochiai, S. Robine …

ONCOGENE 36(42) 5885-5896 2017年10月査読有り
Global metabolic reprogramming of colorectal cancer occurs at adenoma stage and is induced by MYC

武藤誠

Proc Ntnl Acad Sci USA 114(37) E7697-E7706 2017年9月査読有り
AML1-ETO requires enhanced C/D box snoRNA/RNP formation to induce self-renewal and leukaemia

Fengbiao Zhou, Yi Liu, Christian Rohde, Cornelius Pauli, Dennis Gerloff, Marcel Koehn, Danny Misiak, Nicole Baeumer, Chunhong Cui, Stefanie Goellner …

NATURE CELL BIOLOGY 19(7) 844-+ 2017年7月査読有り
Distinct Roles of HES1 in Normal Stem Cells and Tumor Stem-like Cells of the Intestine

Norihiro Goto, Taro Ueo, Akihisa Fukuda, Kenji Kawada, Yoshiharu Sakai, Hiroyuki Miyoshi, Makoto Mark Taketo, Tsutomu Chiba, Hiroshi Seno

CANCER RESEARCH 77(13) 3442-3454 2017年7月査読有り
A Critical Role of Presynaptic Cadherin/Catenin/p140Cap Complexes in Stabilizing Spines and Functional Synapses in the Neocortex

Min-Yin Li, Wan-Ying Miao, Qiu-Zi Wu, Shun-Ji He, Guoquan Yan, Yanrui Yang, Jia-Jia Liu, M. Mark Taketo, Xiang Yu

NEURON 94(6) 1155-+ 2017年6月査読有り

もっとみる

MISC

Wnt signaling induces proliferation of sensory precursors in the postnatal mouse cochlea

Renjie Chai, Bryan Kuo, Tian Wang, Eric J. Liaw, Anping Xia, Taha A. Jan, Zhiyong Liu, Makoto M. Taketo, John S. Oghalai, Roeland Nusse …

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 109(21) 8167-8172 2012年5月査読有り
Increased Wingless (Wnt) signaling in pituitary progenitor/stem cells gives rise to pituitary tumors in mice and humans

Carles Gaston-Massuet, Cynthia Lilian Andoniadou, Massimo Signore, Sujatha A. Jayakody, Nicoletta Charolidi, Roger Kyeyune, Bertrand Vernay, Thomas S. Jacques, Makoto Mark Taketo, Paul Le Tissier …

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 108(28) 11482-11487 2011年7月査読有り
Prospero-related homeobox 1 gene (Prox1) is regulated by canonical Wnt signaling and has a stage-specific role in adult hippocampal neurogenesis

Oezlem Karalay, Kathrin Doberauer, Krishna C. Vadodaria, Marlen Knobloch, Lucia Berti, Amaya Miquelajauregui, Manuela Schwark, Ravi Jagasia, Makoto M. Taketo, Victor Tarabykin …

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 108(14) 5807-5812 2011年4月査読有り
β-Catenin activity in the dermal papilla of the hair follicle regulates pigment-type switching

D. Enshell-Seijffers, C. Lindon, E. Wu, M.M. Taketo, B.A. Morgan

Proceedings of the National Academy of Sciences of the United States of America 107(50) 21564-21569 2010年12月査読有り
Focal Müllerian duct retention in male mice with constitutively activated β-catenin expression in the Müllerian duct mesenchyme

P.S. Tanwar, L. Zhang, Y. Tanaka, M.M. Taketo, P.K. Donahoe, J.M. Teixeira

Proceedings of the National Academy of Sciences of the United States of America 107(37) 16142-16147 2010年9月査読有り
Inactivation of chemokine (C-C motif) receptor 1 (CCR1) suppresses colon cancer liver metastasis by blocking accumulation of immature myeloid cells in a mouse model

Takanori Kitamura, Teruaki Fujishita, Pius Loetscher, Laszlo Revesz, Hiroki Hashida, Shinae Kizaka-Kondoh, Masahiro Aoki, Makoto M. Taketo

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 107(29) 13063-13068 2010年7月査読有り
Inhibition of the mTORC1 pathway suppresses intestinal polyp formation and reduces mortality in Apc^Δ716 mice

T. Fujishita, K. Aoki, H.A. Lane, M. Aoki, M.M. Taketo

Proceedings of the National Academy of Sciences of the United States of America 105(36) 13544-13549 2008年9月査読有り
MicroCT and microMRI imaging of a prenatal mouse model of increased brain size

Elisabeth K. N. Lopez, Stuart R. Stock, Makoto M. Taketo, Anjen Chenn, Matthew J. Ravosa

DEVELOPMENTS IN X-RAY TOMOGRAPHY VI 7078 2008年査読有り
Distinct roles of Wnt/β-catenin and Bmp signaling during early cardiogenesis

A. Klaus, Y. Saga, M.M. Taketo, E. Tzahor, W. Birchmeier

Proceedings of the National Academy of Sciences of the United States of America 104(47) 18531-18536 2007年11月査読有り
Canonical Wnt signaling is a positive regulator of mammalian cardiac progenitors

Chulan Kwon, Joshua Arnold, Edward C. Hsiao, Makoto M. Taketo, Bruce R. Conklin, Deepak Srivastava

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 104(26) 10894-10899 2007年6月査読有り
Wnt signaling regulates pancreatic β cell proliferation

I.C. Rulifson, S.K. Karnik, P.W. Heiser, D. Ten Berge, H. Chen, X. Gu, M.M. Taketo, R. Nusse, M. Hebrok, S.K. Kim

Proceedings of the National Academy of Sciences of the United States of America 104(15) 6247-6252 2007年4月査読有り
Continuous tooth generation in mouse is induced by activated epithelial Wnt/β-catenin signaling

E. Järvinen, I. Salazar-Ciudad, W. Birchmeier, M.M. Taketo, J. Jernvall, I. Thesleff

Proceedings of the National Academy of Sciences of the United States of America 103(49) 18627-18632 2006年12月査読有り
Activation of β-catenin signaling in differentiated mammary secretory cells induces transdifferentiation into epidermis and squamous metaplasias

K. Miyoshi, J.M. Shillingford, F. Le Provost, F. Gounari, R. Bronson, H. Von Boehmer, M.M. Taketo, R.D. Cardiff, L. Hennighausen, K. Khazaie

Proceedings of the National Academy of Sciences of the United States of America 99(1) 219-224 2002年1月査読有り
Multiple functional defects in peripheral autonomic organs in mice lacking muscarinic acetylcholine receptor gene for the M-3 subtype

M Matsui, D Motomura, H Karasawa, T Fujikawa, J Jiang, Y Komiya, S Takahashi, MM Taketo

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 97(17) 9579-9584 2000年8月査読有り
Tertiary hypothyroidism and hyperglycemia in mice with targeted disruption of the thyrotropin-releasing hormone gene

M Yamada, Y Saga, N Shibusawa, J Hirato, M Murakami, T Iwasaki, K Hashimoto, T Satoh, K Wakabayashi, MM Taketo …

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 94(20) 10862-10867 1997年9月査読有り
Early embryonic lethality caused by targeted disruption of the mouse selenocysteine tRNA gene (Trsp)

MR Bosl, K Takaku, M Oshima, S Nishimura, MM Taketo

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 94(11) 5531-5534 1997年5月査読有り
LOSS OF APC HETEROZYGOSITY AND ABNORMAL TISSUE BUILDING IN NASCENT INTESTINAL POLYPS IN MICE CARRYING A TRUNCATED APC GENE

M OSHIMA, H OSHIMA, K KITAGAWA, M KOBAYASHI, C ITAKURA, M TAKETO

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 92(10) 4482-4486 1995年5月査読有り
FVB/N - AN INBRED MOUSE STRAIN PREFERABLE FOR TRANSGENIC ANALYSES

M TAKETO, AC SCHROEDER, LE MOBRAATEN, KB GUNNING, G HANTEN, RR FOX, TH RODERICK, CL STEWART, F LILLY, CT HANSEN …

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 88(6) 2065-2069 1991年3月査読有り
A CELLULAR ENHANCER OF RETROVIRUS GENE-EXPRESSION IN EMBRYONAL CARCINOMA-CELLS

M TAKETO, M TANAKA

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 84(11) 3748-3752 1987年6月査読有り
ISOLATION OF EMBRYONAL CARCINOMA CELL-LINES THAT EXPRESS INTEGRATED RECOMBINANT GENES FLANKED BY THE MOLONEY MURINE LEUKEMIA-VIRUS LONG TERMINAL REPEAT

M TAKETO, E GILBOA, MI SHERMAN

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 82(8) 2422-2426 1985年査読有り

もっとみる

書籍等出版物

ワインバーグ『がんの生物学』第２版

武藤誠 (担当:共訳, 範囲:全文)

南江堂 2017年6月
ワインバーグ「がんの生物学」

武藤誠, 青木正博 (担当:共訳)

南江堂 2008年

所属学協会

共同研究・競争的資金等の研究課題

産業財産権

特願2013-104027 METHOD FOR DETERMINING PROGNOSIS OF CANCER

武藤誠, 高等教育院, 医学研究科, 園下将大, 医学研究科, 坂井義治, 医学研究科, 消化管外科学, 河田健二, 医学研究科, 消化管外科学, 板谷喜朗, 医学研究科, 消化管外科