2004年10月
Expansion and activation of minor histocompatibility antigen HY-specific T cells associated with graft-versus-leukemia response
BONE MARROW TRANSPLANTATION
- 巻
- 34
- 号
- 8
- 開始ページ
- 703
- 終了ページ
- 709
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1038/sj.bmt.1704583
- 出版者・発行元
- NATURE PUBLISHING GROUP
The immune system of females is capable of recognizing and reacting against the male-specific minor histocompatibility antigen (mHA), HY. Thus, cytotoxic T-lymphocytes (CTLs) recognizing this antigen may be useful in eradicating leukemic cells of a male patient if they can be generated in vivo or in vitro from a human leukocyte antigen (HLA)-identical female donor. The HLAA* 0201-restricted HY antigen, FIDSYICQV, is a male-specific mHA. Using HLA-A2/HY peptide tetrameric complexes, we reveal a close association between the emergence of HY peptide-specific CD8(+) T cells in peripheral blood and molecular remission of relapsed BCR/ABL(+) chronic myelogenous leukemia in lymphoid blast crisis in a patient who underwent female-to-male transplantation. Assessment of intracellular cytokine levels identified T cells that produce interferon-gamma in response to the HY peptide during the presence of HY tetramer-positive T cells. These results indicate that transplant with allogeneic HY-specific CTLs has therapeutic potential for relapsed leukemia, and that expansion of such T cells may be involved in the development of a graft-versus-leukemia response against lymphoblastic leukemia cells.
- リンク情報
- ID情報
-
- DOI : 10.1038/sj.bmt.1704583
- ISSN : 0268-3369
- Web of Science ID : WOS:000224249300006