2004
Intramyocardial CD34(+) cell transplantation combined with off-pump coronary artery bypass grafting
HEART SURGERY FORUM
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- Volume
- 7
- Number
- 4
- First page
- E285
- Last page
- E287A
- Language
- English
- Publishing type
- DOI
- 10.1532/HSF98.20041018
- Publisher
- FORUM MULTIMEDIA PUBLISHING, LLC
This report describes a new therapeutic approach for severe ischemic heart disease, intramyocardial transplantation of autologous bone marrow-derived CD34(+) cells combined with off-pump coronary artery bypass grafting (CABG). CD34 is widely known as a cell surface antigen expressed on hematopoietic stem cells, and recent experimental studies have shown that CD34(+) cells include endothelial progenitor cells. We used the Isolex 300i magnetic cell selection system to separate CD34(+) cells from bone marrow cells. This report describes the first case treated with the combination of off-pump CABG and cell transplantation for therapeutic angiogenesis and myocardial regeneration. The transplantation of autologous bone marrow-derived CD34(+) cells improved perfusion of the ungraftable ischemic area.
- Link information
- ID information
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- DOI : 10.1532/HSF98.20041018
- ISSN : 1098-3511
- Web of Science ID : WOS:000223999300007