廣田久雄 (Hisao Hirota) - マイポータル - researchmap

基本情報

所属: 旧所属大阪大学大学院医学系研究科内科系臨床医学専攻助手

学位: 博士(医学)(大阪大学)

J-GLOBAL ID: 200901027994636867
researchmap会員ID: 1000202284

研究キーワード

2

研究分野

1

ライフサイエンス / 循環器内科学 /

経歴

2

学歴

2

- 1985年

鳥取大学, 医学部, 医学科
- 1985年

鳥取大学

受賞

1

1996年

八木賞

MISC

30

Smad1 Protects Cardiomyocytes from Ischemia-Reperfusion Injury.

Circulation 2005年
Smad1 Protects Cardiomyocytes from Ischemia-Reperfusion Injury.

Circulation 2005年
Novel Insertional Mutation in the Bone Morphogenetic Protein Receptor type II Associated with Sporadic Primary Pulmonary Hypertension.

Circulation Journal 68, 592-594 2004年
Novel Insertional Mutation in the Bone Morphogenetic Protein Receptor type II Associated with Sporadic Primary Pulmonary Hypertension.

Circulation Journal 68, 592-594 2004年
Activation of gp130 Transduces Hypertrophic Signal Through Interaction of Scattolding/Docking Protein Gabl with Tyrosine Phosphatase SHP2 in Cardiomyocytes

Circ Res 93 : 221-229 2003年
Activation of gp130 Transduces Hypertrophic Signal Through Interaction of Scattolding/Docking Protein Gabl with Tyrosine Phosphatase SHP2 in Cardiomyocytes

Circ Res 93 : 221-229 2003年
Specific cardiomyopathy caused by multisystemic lipid storage in Jordan's anomaly

Y Oshima, H Hirota, H Nagai, M Izumi, Y Nakaoka, T Osugi, Y Fujio, H Tateyama, M Kikui, K Yamauchi-Takihara …

CIRCULATION 106(2) 280-281 2002年7月
Cardiac-specific activation of signal transducer and activator of transcription 3 promotes vascular formation in the heart

T Osugi, Y Oshima, Y Fujio, M Funamoto, A Yamashita, S Negoro, K Kunisada, M Izumi, Y Nakaoka, H Hirota …

JOURNAL OF BIOLOGICAL CHEMISTRY 277(8) 6676-6681 2002年2月
Aldosterone augments endothelin-I-induced sardiac myocyte hypertrophy with the reinforcement of the JNK pathway

FEBS Lett 31, 524(1-3), 123-6 2002年
Bcl-xl reduces doxorubicin-induced myodardial damage but fails to control cardiac gene downregulation

Cardiovasc Res 53(4), 936-43 2002年
Bone morphogenetic protein-2 inhibits serum deprivation-induced apoptosis of neonatal cardiac myocytes through activation of the Smad1 pathway.

J Biol; Chem 7276(33):31133-31141 2001年
Bone morphogenetic protein-2 inhibits serum deprivation-induced apoptosis of neonatal cardiac myocytes through activation of the Smad1 pathway.

J Biol; Chem 7276(33):31133-31141 2001年
Activation of signal transducer and activator of rtanscription 3 protects cardiomyocytes from hypoxia/reoxugenation-induced oxidative stress through the uptegu;ation of mangamese superoxide dismutase

Circulation 104(9), 979-981 2001年
Bone morphogenetic protein Z inhibits serum deprivation-induced a poptosis of neonatal cardiac myocytes through the activation of Smad 1 pathway.

J Biol Chem 7276, 31133-31141 2001年
Signal transducer and activator of transcription 3 is required for glycoprotein 130 mediated induction of vascular endothelial growth factor in cardiac myocytes.

J Biol Chem. 275, 10561-10566 2000年
Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress

H Hirota, J Chen, UAK Betz, K Rajewsky, Y Gu, J Ross, W Muller, KR Chien

CELL 97(2) 189-198 1999年4月
Activation of phosphatidylinositol 3-kinase through glycoprotein 130 induces protein kinase B and p70 S6 kinase phosphorylation in cardiac myocytes.

J Biol Chem 273(16) 9703-9710 1998年
Impairment of antigen-specific antibody production in transgenic mice expressing a dominant-negative form of gp130.

Proc Natl Acad Sci U S A 94(6) 2478-2482 1997年
Signals through gp130 upregulate bcl-x gene expression via STAT1-binding ciselement cardiac myocytes.

J Clin Invest 99 2898-905 1997年
gp130 signaling pathways: Recent advances and implications for cardiovascular disease

H Hirota, K Yoshida, T Taga, T Kishimoto

TRENDS IN CARDIOVASCULAR MEDICINE 6(4) 109-115 1996年5月

もっとみる

書籍等出版物

2

Signal Transducers And Activators of Transcription(STATS) STATS in Cardiovascular System

Kluwer Academic Publishers.
Signal Transducers And Activators of Transcription(STATS) STATS in Cardiovascular System

Kluwer Academic Publishers.

所属学協会

2

Works(作品等)

2

心血管病におけるサイトカイン療法

2000年
Cytokine therapy in cardiovascular medicine

2000年

共同研究・競争的資金等の研究課題

8

肺高血圧症における病態解析

科学研究費補助金 2001年
Clinical Analysis of Pulmonary Hypertension

Grant-in-Aid for Scientific Research 2001年
肺高血圧症に対する新たな治療戦略

その他の研究制度
心血管病におけるサイトカイン療法

その他の研究制度
心血管系におけるサイトカインの役割

科学研究費補助金
New Therapy for Pulmonary Hypertension

The Other Research Programs
Cytokine therapy in cardiovascular medicine

The Other Research Programs
Role of Cytokines in the Cardiovascular system

Grant-in-Aid for Scientific Research