2016年10月
Nickel-Catalyzed Construction of Chiral 1-[6]Helicenols and Application in the Synthesis of [6]Helicene-Based Phosphinite Ligands
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
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- 巻
- 2016
- 号
- 29
- 開始ページ
- 4948
- 終了ページ
- 4952
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1002/ejoc.201600677
- 出版者・発行元
- WILEY-V C H VERLAG GMBH
Two 1-[6]helicenol derivatives were synthesized by Ni-catalyzed [2+2+2] cycloaddition on a multigram scale. Both enantiomers of the 1-[6]helicenols could be efficiently prepared by simple optical resolution. As a synthetic application of helically chiral 1-[6]helicenols, a novel class of [6]helicene-based phosphinites was developed; these compounds represent the first examples of helically chiral phosphinite ligands. Up to 90 % ee was obtained for the Pd-catalyzed asymmetric allylic alkylation reaction.
- リンク情報
- ID情報
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- DOI : 10.1002/ejoc.201600677
- ISSN : 1434-193X
- eISSN : 1099-0690
- Web of Science ID : WOS:000386920600002