2010年12月
Comparing the Cochlear Spiral Modiolar Artery in Type-1 and Type-2 Diabetes Mellitus: A Human Temporal Bone Study
ACTA MEDICA OKAYAMA
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- 巻
- 64
- 号
- 6
- 開始ページ
- 375
- 終了ページ
- 383
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.18926/AMO/41323
- 出版者・発行元
- OKAYAMA UNIV MED SCHOOL
This study examined whether pathological findings were present in cochlear vessels for patients with diabetes mellitus. Twenty-six temporal bones from 13 patients with type 1 diabetes mellitus and 40 temporal bones from 20 patients with type 2 diabetes mellitus were examined. Type 2 diabetic temporal bones were divided into 2 groups according to diabetic management (22 temporal bones with insulin therapy, and 18 with oral hypoglycemic drugs). Age-matched normal control temporal bones were also selected. The vessel wall thickness in the cochlear spiral modiolar artery was measured under a light microscope, and the vessel wall ratio (vessel wall thickness/outer diameter of the vessel x 100) was calculated. The vessel wall thickness and vessel wall ratio in type 1 diabetes mellitus were significantly greater than in normal controls. Type 2 diabetic patients with insulin therapy showed significantly greater vessel wall thickness and vessel wall ratios than controls. In type 2 diabetes mellitus, the vessel wall thickness and vessel wall ratio were greater in patients treated with insulin therapy than in those treated with oral hypoglycemic agents. Type 2 diabetic patients with insulin therapy showed an increased vessel wall thickness and vessel wall ratio compared to patients with type 1 diabetes mellitus. In conclusion, the cochlea in patients with diabetes mellitus shows circulatory disturbance compared to age-matched normal controls.
- リンク情報
- ID情報
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- DOI : 10.18926/AMO/41323
- ISSN : 0386-300X
- Web of Science ID : WOS:000285664200004