MISC

2014年10月

Chronic rhinosinusitis patients have decreased lung function

INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
  • Shin Kariya
  • ,
  • Mitsuhiro Okano
  • ,
  • Takaya Higaki
  • ,
  • Yasuyuki Noyama
  • ,
  • Takenori Haruna
  • ,
  • Hisashi Ishihara
  • ,
  • Takuma Makino
  • ,
  • Tomoo Onoda
  • ,
  • Kazunori Nishizaki

4
10
開始ページ
828
終了ページ
833
記述言語
英語
掲載種別
DOI
10.1002/alr.21370
出版者・発行元
WILEY-BLACKWELL

Background: The relationship between upper and lower airway diseases has been reported. However, the pulmonary function of patients with chronic rhinosinusitis (CRS) has not been fully examined.
Methods: Pulmonary function was measured in 273 patients with CRS and 100 age-matched normal control subjects. No patients with chronic obstructive pulmonary disease (COPD) were included in this study. The patients with CRS were divided into 8 subgroups based on the presence of asthma, sensitization to common inhaled antigens, and nasal polyposis. The relationships between pulmonary function and clinical parameters, including radiographic severity of CRS according to the Lund-Mackay computed tomography (CT) staging system, eosinophil count in the peripheral blood, and serum total immunoglobulin E (IgE) levels, were assessed.
Results: In pulmonary function testing, the CRS patients had affected pulmonary function. The CRS patients without asthma showed latent obstructive pulmonary function changes when compared to normal controls. No significant correlations were observed between pulmonary function and any clinical parameters (Lund-Mackay CT staging score, eosinophil count in the peripheral blood, and serum total IgE levels).
Conclusion: CRS patients had significant obstructive lung function changes regardless of the presence of asthma. The patients with CRS who had not been clinically diagnosed as having lower respiratory tract diseasesmight have had subclinical lower airway diseases. Therefore, clinicians should be aware of pulmonary function and lower lung diseases in patients with CRS. (C) 2014 ARS-AAOA, LLC.

Web of Science ® 被引用回数 : 16

リンク情報
DOI
https://doi.org/10.1002/alr.21370
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000342842400009&DestApp=WOS_CPL

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