MISC

2014年10月

Does HMGB1 predict occult neck lymph node metastasis in early tongue carcinoma? A case-control study of 26 patients

JOURNAL OF LARYNGOLOGY AND OTOLOGY
  • H. Hanakawa
  • ,
  • Y. Orita
  • ,
  • Y. Sato
  • ,
  • M. Takeuchi
  • ,
  • S. Takao
  • ,
  • K. Ohno
  • ,
  • T. Kohno
  • ,
  • N. Iwaki
  • ,
  • H. Marunaka
  • ,
  • R. Tamamura
  • ,
  • M. Nishibori
  • ,
  • H. Nagatsuka
  • ,
  • K. Nishizaki
  • ,
  • T. Yoshino

128
10
開始ページ
926
終了ページ
931
記述言語
英語
掲載種別
DOI
10.1017/S0022215114001819
出版者・発行元
CAMBRIDGE UNIV PRESS

Objective: This study examined whether the occurrence of late neck metastasis in early tongue squamous cell carcinoma can be predicted by evaluating HMGB1 (high mobility group box 1) expression in the primary lesion.
Methods: A case-control study was conducted. The cases comprised 10 patients with late neck metastasis. The controls consisted of 16 patients without recurrence. All were examined immunohistochemically for HMGB1 protein expression. The odds ratio for late neck metastasis in relation to HMGB1 was estimated.
Results: Results for HMGB1 were dichotomised into positive staining scores (score, 5-7) and negative scores (0-4). Six cases (60 per cent) and four controls (25 per cent) were HMGB1-positive. Although no significant result was seen, compared with HMGB1-negative patients the odds ratio for late neck metastasis in HMGB1-positive patients was 3.8 (95 per cent confidence interval, 0.6-26.5) after adjusting for other factors.
Conclusion: In the present study, immunohistochemical study of HMGB1 in early tongue squamous cell carcinoma did not appear to be very useful for predicting occult neck metastasis. Further study is necessary to clarify the relationship between HMGB1 expression and late neck metastasis in early tongue squamous cell carcinoma.

Web of Science ® 被引用回数 : 3

リンク情報
DOI
https://doi.org/10.1017/S0022215114001819
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000343871200014&DestApp=WOS_CPL

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