MISC

2015年12月

Histopathologic Findings in Peripheral Vestibular System From Patients With Systemic Lupus Erythematosus: A Human Temporal Bone Study

OTOLOGY & NEUROTOLOGY
  • Shin Kariya
  • ,
  • Omer Hizli
  • ,
  • Serdar Kaya
  • ,
  • Pelin Hizli
  • ,
  • Kazunori Nishizaki
  • ,
  • Michael M. Paparella
  • ,
  • Sebahattin Cureoglu

36
10
開始ページ
1702
終了ページ
1707
記述言語
英語
掲載種別
DOI
10.1097/MAO.0000000000000897
出版者・発行元
LIPPINCOTT WILLIAMS & WILKINS

Hypothesis: We hypothesized that a pathologic condition exists in vestibular hair cells in human temporal bones from patients with systemic lupus erythematosus (SLE).
Background: A significant association between sensorineural hearing loss and autoimmune disease has been reported. Patients with SLE also frequently have vestibular symptoms whose pathophysiologic mechanism is unclear.
Methods: We examined 15 temporal bone samples from 8 patients with SLE, along with 21 samples from 17 age-matched healthy control patients. The samples were serially sectioned in the horizontal plane and stained with hematoxylin and eosin. Using differential interference contrast microscopy, we counted the number of type I and type II hair cells in the saccular macula, the utricular macula, and the cristae of the three semicircular canals; then, we calculated the hair cell density (cells per 0.01 mm(2)).
Results: The mean density of type I hair cells in our SLE group was significantly lower than in our control group in the saccular macula, in the utricular macula, and in the superior, lateral, and posterior semicircular canals. But in all five vestibular sensory epithelia, the mean density of type II hair cells did not significantly differ between our two groups. In our SLE group, the mean density of vestibular hair cells did not significantly correlate with the patient's age at death or with the duration of SLE.
Conclusion: Type I hair cells in peripheral vestibular organs are affected in patients with SLE. Our findings could provide a pathologic basis for the difficulty with balance experienced by patients with SLE.

Web of Science ® 被引用回数 : 7

リンク情報
DOI
https://doi.org/10.1097/MAO.0000000000000897
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000368020200021&DestApp=WOS_CPL

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