MISC

2015年4月

Association and management of eosinophilic inflammation in upper and lower airways

ALLERGOLOGY INTERNATIONAL
  • Mitsuhiro Okano
  • ,
  • Shin Kariya
  • ,
  • Nobuo Ohta
  • ,
  • Yoshimasa Imoto
  • ,
  • Shigeharu Fujieda
  • ,
  • Kazunori Nishizaki

64
2
開始ページ
131
終了ページ
138
記述言語
英語
掲載種別
書評論文,書評,文献紹介等
DOI
10.1016/j.alit.2015.01.004
出版者・発行元
JAPANESE SOCIETY ALLERGOLOGY

This review discussed the contribution of eosinophilic upper airway inflammation includes allergic rhinitis (AR) and chronic rhinosinusitis (CRS) to the pathophysiology and course of asthma, the representative counterpart in the lower airway. The presence of concomitant AR can affect the severity of asthma in patients who have both diseases; however, it is still debatable whether the presence of asthma affects the severity of AR. Hypersensitivity, obstruction and/or inflammation in the lower airway can be detected in patients with AR without awareness or diagnosis of asthma, and AR is known as a risk factor for the new onset of wheeze and asthma both in children and adults. Allergen immunotherapy, pharmacotherapy and surgery for AR can contribute to asthma control; however, a clear preventive effect on the new onset of asthma has been demonstrated only for immunotherapy. Pathological similarities such as epithelial shedding are also seen between asthma and CRS, especially eosinophilic CRS. Abnormal sinus findings on computed tomography are seen in the majority of asthmatic patients, and asthmatic patients with CRS show a significant impairment in Quality of Life (QOL) and pulmonary function as compared to those without CRS. Conversely, lower airway inflammation and dysfunction are seen in non-asthmatic patients with CRS. Treatments for CRS that include pharmacotherapy such as anti-leukotrienes, surgery, and aspirin desensitization show a beneficial effect on concomitant asthma. Acting as a gatekeeper of the united airways, the control of inflammation in the nose is crucial for improvement of the QOL of patients with co-existing AR/CRS and asthma. Copyright (C) 2015, Japanese Society of Allergology. Production and hosting by Elsevier B.V. All rights reserved.

Web of Science ® 被引用回数 : 19

リンク情報
DOI
https://doi.org/10.1016/j.alit.2015.01.004
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000353751800003&DestApp=WOS_CPL

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