Papers

Sep, 2021

Transformation to diffuse large B-cell lymphoma with germinal center B-cell like subtype and discordant light chain expression in a patient with Waldenström macroglobulinemia/lymphoplasmacytic lymphoma.

International journal of hematology
  • Hiroki Kobayashi
  • Noboru Asada
  • Yuria Egusa
  • Tomoka Ikeda
  • Misa Sakamoto
  • Masaya Abe
  • Daisuke Ennishi
  • Masahiro Sakata
  • Akinobu Takaki
  • Soichiro Kawahara
  • Yusuke Meguri
  • Hisakazu Nishimori
  • Nobuharu Fujii
  • Ken-Ichi Matsuoka
  • Yasuharu Sato
  • Tadashi Yoshino
  • Yoshinobu Maeda
  • Display all

Volume
114
Number
3
First page
401
Last page
407
Language
English
Publishing type
Research paper (scientific journal)
DOI
10.1007/s12185-021-03157-z

Waldenström macroglobulinemia (WM)/lymphoplasmacytic lymphoma (LPL) is a rare indolent B-cell neoplasm, and a gain-of-function mutation in the myeloid differentiation primary response 88 (MYD88), L265P, is a commonly recurring mutation in patients with WM/LPL. Histological transformation of WM/LPL to an aggressive lymphoma such as diffuse large B-cell lymphoma (DLBCL) is rare, and transformed DLBCL has a worse prognosis than de novo DLBCL, partly because transformed DLBCL is mostly classified as non-germinal center B-cell-like (non-GCB) subtype. We herein describe a 75-year-old man with DLBCL with a history of WM/LPL. DLBCL in this patient showed the GCB subtype, and the light chain restriction of DLBCL was different from that of the antecedent WM/LPL, indicating that the two types of lymphoma cells had distinctive origins. However, DLBCL in this patient harbored the MYD88 L265P mutation, and polymerase chain reaction and Sanger sequencing of the DLBCL and WM/LPL for immunoglobulin heavy chain gene rearrangement suggested a clonal relationship between the two lymphomas. Since the outcome of transformed DLBCL is worse than for de novo DLBCL, it is important to evaluate the clonal relationship between primary WM/LPL and the corresponding transformed DLBCL, even if the DLBCL expresses a GCB subtype or discordant light chain restriction.

Link information
DOI
https://doi.org/10.1007/s12185-021-03157-z
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33907976
ID information
  • DOI : 10.1007/s12185-021-03157-z
  • Pubmed ID : 33907976

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